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Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults

Krebs von den Lungen-6 (KL-6) is a promising biomarker for the diagnosis and prognosis of interstitial lung disease. However, reference intervals in Northern Europeans remain to be established using a latex-particle-enhanced turbidimetric immunoassay. The participants were Danish blood donors subjec...

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Autores principales: Bruun, Stine Bakkensen, Madsen, Jeppe Buur, Brasen, Claus Lohman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253194/
https://www.ncbi.nlm.nih.gov/pubmed/37296803
http://dx.doi.org/10.3390/diagnostics13111951
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author Bruun, Stine Bakkensen
Madsen, Jeppe Buur
Brasen, Claus Lohman
author_facet Bruun, Stine Bakkensen
Madsen, Jeppe Buur
Brasen, Claus Lohman
author_sort Bruun, Stine Bakkensen
collection PubMed
description Krebs von den Lungen-6 (KL-6) is a promising biomarker for the diagnosis and prognosis of interstitial lung disease. However, reference intervals in Northern Europeans remain to be established using a latex-particle-enhanced turbidimetric immunoassay. The participants were Danish blood donors subjected to strict health requirements. Analyses were performed using the Nanopia KL-6 reagent on the cobas 8000 module c502. Sex-partitioned reference intervals were determined using a parametric quantile approach according to the Clinical and Laboratory Standards Institute guideline EP28-A3c. The study included 240 participants—121 females and 119 males. The common reference interval was 59.4–398.5 U/mL (95% confidence intervals (CI) for the lower and upper limits were 47.3–71.9 and 369.5–430.1, respectively). For females, the reference interval was 56.8–324.0 U/mL (95% CIs for the lower and upper limits were 36.1–77.6 and 303.3–344.7, respectively). For males, the reference interval was 51.5–448.7 U/mL (95% CIs for the lower and upper limits were 32.8–71.2 and 397.3–508.1, respectively). These results emphasize the importance of sex partitioning when evaluating KL-6 reference intervals. The reference intervals increase the clinical applicability of the KL-6 biomarker and provide a basis for future scientific studies of its utility in patient management.
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spelling pubmed-102531942023-06-10 Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults Bruun, Stine Bakkensen Madsen, Jeppe Buur Brasen, Claus Lohman Diagnostics (Basel) Communication Krebs von den Lungen-6 (KL-6) is a promising biomarker for the diagnosis and prognosis of interstitial lung disease. However, reference intervals in Northern Europeans remain to be established using a latex-particle-enhanced turbidimetric immunoassay. The participants were Danish blood donors subjected to strict health requirements. Analyses were performed using the Nanopia KL-6 reagent on the cobas 8000 module c502. Sex-partitioned reference intervals were determined using a parametric quantile approach according to the Clinical and Laboratory Standards Institute guideline EP28-A3c. The study included 240 participants—121 females and 119 males. The common reference interval was 59.4–398.5 U/mL (95% confidence intervals (CI) for the lower and upper limits were 47.3–71.9 and 369.5–430.1, respectively). For females, the reference interval was 56.8–324.0 U/mL (95% CIs for the lower and upper limits were 36.1–77.6 and 303.3–344.7, respectively). For males, the reference interval was 51.5–448.7 U/mL (95% CIs for the lower and upper limits were 32.8–71.2 and 397.3–508.1, respectively). These results emphasize the importance of sex partitioning when evaluating KL-6 reference intervals. The reference intervals increase the clinical applicability of the KL-6 biomarker and provide a basis for future scientific studies of its utility in patient management. MDPI 2023-06-02 /pmc/articles/PMC10253194/ /pubmed/37296803 http://dx.doi.org/10.3390/diagnostics13111951 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Bruun, Stine Bakkensen
Madsen, Jeppe Buur
Brasen, Claus Lohman
Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults
title Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults
title_full Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults
title_fullStr Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults
title_full_unstemmed Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults
title_short Establishing Sex-Dependent Reference Intervals for KL-6 in Danish Adults
title_sort establishing sex-dependent reference intervals for kl-6 in danish adults
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253194/
https://www.ncbi.nlm.nih.gov/pubmed/37296803
http://dx.doi.org/10.3390/diagnostics13111951
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