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The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis

Background: Transbronchial lung cryobiopsy (TBLC) has widely used for the diagnosis of diffuse lung disease. However, it remains unclear whether TBLC is useful for the diagnosis in hypersensitivity pneumonitis (HP). Methods: We investigated 18 patients who underwent TBLC and were diagnosed with HP b...

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Autores principales: Ohno, Shuuhei, Zaizen, Yoshiaki, Matama, Goushi, Chikasue, Tomonori, Tokisawa, Saeko, Okamoto, Masaki, Tabata, Kazuhiro, Tominaga, Masaki, Akiba, Jun, Fujimoto, Kiminori, Fukuoka, Junya, Hoshino, Tomoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253264/
https://www.ncbi.nlm.nih.gov/pubmed/37297858
http://dx.doi.org/10.3390/jcm12113663
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author Ohno, Shuuhei
Zaizen, Yoshiaki
Matama, Goushi
Chikasue, Tomonori
Tokisawa, Saeko
Okamoto, Masaki
Tabata, Kazuhiro
Tominaga, Masaki
Akiba, Jun
Fujimoto, Kiminori
Fukuoka, Junya
Hoshino, Tomoaki
author_facet Ohno, Shuuhei
Zaizen, Yoshiaki
Matama, Goushi
Chikasue, Tomonori
Tokisawa, Saeko
Okamoto, Masaki
Tabata, Kazuhiro
Tominaga, Masaki
Akiba, Jun
Fujimoto, Kiminori
Fukuoka, Junya
Hoshino, Tomoaki
author_sort Ohno, Shuuhei
collection PubMed
description Background: Transbronchial lung cryobiopsy (TBLC) has widely used for the diagnosis of diffuse lung disease. However, it remains unclear whether TBLC is useful for the diagnosis in hypersensitivity pneumonitis (HP). Methods: We investigated 18 patients who underwent TBLC and were diagnosed with HP based on pathology or multidisciplinary discussion (MDD). Of the 18 patients, 12 had fibrotic HP (fHP), 2 had non-fibrotic HP (non-fHP) diagnosed with MDD. The remaining 4 patients were diagnosed with fHP by pathology but not by MDD because of clinical features. The radiology and pathology of these cases were compared. Results: All patients with fHP showed radiological findings of inflammation, fibrosis, and airway disease. Conversely, pathology showed fibrosis and inflammation in 11 of 12 cases (92%), but airway disease was significantly less common with 5 cases (42%) (p = 0.014). Non-fHP showed inflammatory cell infiltration mainly in the centrilobule on pathology, which was consistent with radiology. Granulomas were found in 5 patients with HP (36%). In the non-HP group, airway-centered interstitial fibrosis was observed in 3 patients (75%) with pathology. Conclusions: The pathology with TBLC is difficult to evaluate airway disease of HP. We need to understand this characteristic of TBLC to make a MDD diagnosis of HP.
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spelling pubmed-102532642023-06-10 The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis Ohno, Shuuhei Zaizen, Yoshiaki Matama, Goushi Chikasue, Tomonori Tokisawa, Saeko Okamoto, Masaki Tabata, Kazuhiro Tominaga, Masaki Akiba, Jun Fujimoto, Kiminori Fukuoka, Junya Hoshino, Tomoaki J Clin Med Article Background: Transbronchial lung cryobiopsy (TBLC) has widely used for the diagnosis of diffuse lung disease. However, it remains unclear whether TBLC is useful for the diagnosis in hypersensitivity pneumonitis (HP). Methods: We investigated 18 patients who underwent TBLC and were diagnosed with HP based on pathology or multidisciplinary discussion (MDD). Of the 18 patients, 12 had fibrotic HP (fHP), 2 had non-fibrotic HP (non-fHP) diagnosed with MDD. The remaining 4 patients were diagnosed with fHP by pathology but not by MDD because of clinical features. The radiology and pathology of these cases were compared. Results: All patients with fHP showed radiological findings of inflammation, fibrosis, and airway disease. Conversely, pathology showed fibrosis and inflammation in 11 of 12 cases (92%), but airway disease was significantly less common with 5 cases (42%) (p = 0.014). Non-fHP showed inflammatory cell infiltration mainly in the centrilobule on pathology, which was consistent with radiology. Granulomas were found in 5 patients with HP (36%). In the non-HP group, airway-centered interstitial fibrosis was observed in 3 patients (75%) with pathology. Conclusions: The pathology with TBLC is difficult to evaluate airway disease of HP. We need to understand this characteristic of TBLC to make a MDD diagnosis of HP. MDPI 2023-05-25 /pmc/articles/PMC10253264/ /pubmed/37297858 http://dx.doi.org/10.3390/jcm12113663 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ohno, Shuuhei
Zaizen, Yoshiaki
Matama, Goushi
Chikasue, Tomonori
Tokisawa, Saeko
Okamoto, Masaki
Tabata, Kazuhiro
Tominaga, Masaki
Akiba, Jun
Fujimoto, Kiminori
Fukuoka, Junya
Hoshino, Tomoaki
The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
title The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
title_full The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
title_fullStr The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
title_full_unstemmed The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
title_short The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
title_sort characteristic of transbronchial lung cryobiopsy in the pathological diagnosis of hypersensitivity pneumonitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253264/
https://www.ncbi.nlm.nih.gov/pubmed/37297858
http://dx.doi.org/10.3390/jcm12113663
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