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The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis
Background: Transbronchial lung cryobiopsy (TBLC) has widely used for the diagnosis of diffuse lung disease. However, it remains unclear whether TBLC is useful for the diagnosis in hypersensitivity pneumonitis (HP). Methods: We investigated 18 patients who underwent TBLC and were diagnosed with HP b...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253264/ https://www.ncbi.nlm.nih.gov/pubmed/37297858 http://dx.doi.org/10.3390/jcm12113663 |
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author | Ohno, Shuuhei Zaizen, Yoshiaki Matama, Goushi Chikasue, Tomonori Tokisawa, Saeko Okamoto, Masaki Tabata, Kazuhiro Tominaga, Masaki Akiba, Jun Fujimoto, Kiminori Fukuoka, Junya Hoshino, Tomoaki |
author_facet | Ohno, Shuuhei Zaizen, Yoshiaki Matama, Goushi Chikasue, Tomonori Tokisawa, Saeko Okamoto, Masaki Tabata, Kazuhiro Tominaga, Masaki Akiba, Jun Fujimoto, Kiminori Fukuoka, Junya Hoshino, Tomoaki |
author_sort | Ohno, Shuuhei |
collection | PubMed |
description | Background: Transbronchial lung cryobiopsy (TBLC) has widely used for the diagnosis of diffuse lung disease. However, it remains unclear whether TBLC is useful for the diagnosis in hypersensitivity pneumonitis (HP). Methods: We investigated 18 patients who underwent TBLC and were diagnosed with HP based on pathology or multidisciplinary discussion (MDD). Of the 18 patients, 12 had fibrotic HP (fHP), 2 had non-fibrotic HP (non-fHP) diagnosed with MDD. The remaining 4 patients were diagnosed with fHP by pathology but not by MDD because of clinical features. The radiology and pathology of these cases were compared. Results: All patients with fHP showed radiological findings of inflammation, fibrosis, and airway disease. Conversely, pathology showed fibrosis and inflammation in 11 of 12 cases (92%), but airway disease was significantly less common with 5 cases (42%) (p = 0.014). Non-fHP showed inflammatory cell infiltration mainly in the centrilobule on pathology, which was consistent with radiology. Granulomas were found in 5 patients with HP (36%). In the non-HP group, airway-centered interstitial fibrosis was observed in 3 patients (75%) with pathology. Conclusions: The pathology with TBLC is difficult to evaluate airway disease of HP. We need to understand this characteristic of TBLC to make a MDD diagnosis of HP. |
format | Online Article Text |
id | pubmed-10253264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102532642023-06-10 The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis Ohno, Shuuhei Zaizen, Yoshiaki Matama, Goushi Chikasue, Tomonori Tokisawa, Saeko Okamoto, Masaki Tabata, Kazuhiro Tominaga, Masaki Akiba, Jun Fujimoto, Kiminori Fukuoka, Junya Hoshino, Tomoaki J Clin Med Article Background: Transbronchial lung cryobiopsy (TBLC) has widely used for the diagnosis of diffuse lung disease. However, it remains unclear whether TBLC is useful for the diagnosis in hypersensitivity pneumonitis (HP). Methods: We investigated 18 patients who underwent TBLC and were diagnosed with HP based on pathology or multidisciplinary discussion (MDD). Of the 18 patients, 12 had fibrotic HP (fHP), 2 had non-fibrotic HP (non-fHP) diagnosed with MDD. The remaining 4 patients were diagnosed with fHP by pathology but not by MDD because of clinical features. The radiology and pathology of these cases were compared. Results: All patients with fHP showed radiological findings of inflammation, fibrosis, and airway disease. Conversely, pathology showed fibrosis and inflammation in 11 of 12 cases (92%), but airway disease was significantly less common with 5 cases (42%) (p = 0.014). Non-fHP showed inflammatory cell infiltration mainly in the centrilobule on pathology, which was consistent with radiology. Granulomas were found in 5 patients with HP (36%). In the non-HP group, airway-centered interstitial fibrosis was observed in 3 patients (75%) with pathology. Conclusions: The pathology with TBLC is difficult to evaluate airway disease of HP. We need to understand this characteristic of TBLC to make a MDD diagnosis of HP. MDPI 2023-05-25 /pmc/articles/PMC10253264/ /pubmed/37297858 http://dx.doi.org/10.3390/jcm12113663 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ohno, Shuuhei Zaizen, Yoshiaki Matama, Goushi Chikasue, Tomonori Tokisawa, Saeko Okamoto, Masaki Tabata, Kazuhiro Tominaga, Masaki Akiba, Jun Fujimoto, Kiminori Fukuoka, Junya Hoshino, Tomoaki The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis |
title | The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis |
title_full | The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis |
title_fullStr | The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis |
title_full_unstemmed | The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis |
title_short | The Characteristic of Transbronchial Lung Cryobiopsy in the Pathological Diagnosis of Hypersensitivity Pneumonitis |
title_sort | characteristic of transbronchial lung cryobiopsy in the pathological diagnosis of hypersensitivity pneumonitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253264/ https://www.ncbi.nlm.nih.gov/pubmed/37297858 http://dx.doi.org/10.3390/jcm12113663 |
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