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Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design

Objective: The risk of reinfection with SARS-CoV-2 has been rapidly increased with the circulation of concerns about variants. So, the aim of our study was to evaluate the factors that increase the risk of this reinfection in healthcare workers compared to those who have never been positive and thos...

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Autores principales: La Torre, Giuseppe, Paglione, Gianluca, Barone, Lavinia Camilla, Cammalleri, Vittoria, Faticoni, Augusto, Marte, Mattia, Pocino, Roberta Noemi, Previte, Carlo Maria, Bongiovanni, Andrea, Colaprico, Corrado, Ricci, Eleonora, Imeshtari, Valentin, Manai, Maria Vittoria, Shaholli, David, Barletta, Vanessa India, Carluccio, Giovanna, Moretti, Luca, Vezza, Francesca, Volpicelli, Lorenzo, Massetti, Anna Paola, Cinti, Lilia, Roberto, Piergiorgio, Napoli, Anna, Antonelli, Guido, Mastroianni, Claudio Maria, Sernia, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253296/
https://www.ncbi.nlm.nih.gov/pubmed/37298055
http://dx.doi.org/10.3390/jcm12113861
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author La Torre, Giuseppe
Paglione, Gianluca
Barone, Lavinia Camilla
Cammalleri, Vittoria
Faticoni, Augusto
Marte, Mattia
Pocino, Roberta Noemi
Previte, Carlo Maria
Bongiovanni, Andrea
Colaprico, Corrado
Ricci, Eleonora
Imeshtari, Valentin
Manai, Maria Vittoria
Shaholli, David
Barletta, Vanessa India
Carluccio, Giovanna
Moretti, Luca
Vezza, Francesca
Volpicelli, Lorenzo
Massetti, Anna Paola
Cinti, Lilia
Roberto, Piergiorgio
Napoli, Anna
Antonelli, Guido
Mastroianni, Claudio Maria
Sernia, Sabina
author_facet La Torre, Giuseppe
Paglione, Gianluca
Barone, Lavinia Camilla
Cammalleri, Vittoria
Faticoni, Augusto
Marte, Mattia
Pocino, Roberta Noemi
Previte, Carlo Maria
Bongiovanni, Andrea
Colaprico, Corrado
Ricci, Eleonora
Imeshtari, Valentin
Manai, Maria Vittoria
Shaholli, David
Barletta, Vanessa India
Carluccio, Giovanna
Moretti, Luca
Vezza, Francesca
Volpicelli, Lorenzo
Massetti, Anna Paola
Cinti, Lilia
Roberto, Piergiorgio
Napoli, Anna
Antonelli, Guido
Mastroianni, Claudio Maria
Sernia, Sabina
author_sort La Torre, Giuseppe
collection PubMed
description Objective: The risk of reinfection with SARS-CoV-2 has been rapidly increased with the circulation of concerns about variants. So, the aim of our study was to evaluate the factors that increase the risk of this reinfection in healthcare workers compared to those who have never been positive and those who have had only one positivity. Methods: A case-control study was carried out at the Teaching Hospital Policlinico Umberto I in Rome, Sapienza University of Rome, in the period between 6 March 2020 and 3 June 2022. Cases are healthcare workers who have developed a reinfection with the SARS-CoV-2 virus, while controls were either healthcare workers who tested positive once or those who have never tested positive for SARS-CoV-2. Results: 134 cases and 267 controls were recruited. Female gender is associated with a higher odds of developing reinfection (OR: 2.42; 95% CI: 1.38–4.25). Moreover, moderate or high alcohol consumption is associated with higher odds of reinfection (OR: 1.49; 95% CI: 1.19–1.87). Diabetes is also associated with higher odds of reinfection (OR: 3.45; 95% CI: 1.41–8.46). Finally, subjects with increased red blood cell counts have higher odds of reinfection (OR: 1.69; 95% CI: 1.21–2.25). Conclusion: From the prevention point of view, these findings indicate that particular attention should be paid to subjects with diabetes mellitus, women and alcoholic drinkers. These results could also suggest that contact tracing represents a fundamental approach model against the SARS-CoV-2 pandemic, together with the health information of participants.
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spelling pubmed-102532962023-06-10 Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design La Torre, Giuseppe Paglione, Gianluca Barone, Lavinia Camilla Cammalleri, Vittoria Faticoni, Augusto Marte, Mattia Pocino, Roberta Noemi Previte, Carlo Maria Bongiovanni, Andrea Colaprico, Corrado Ricci, Eleonora Imeshtari, Valentin Manai, Maria Vittoria Shaholli, David Barletta, Vanessa India Carluccio, Giovanna Moretti, Luca Vezza, Francesca Volpicelli, Lorenzo Massetti, Anna Paola Cinti, Lilia Roberto, Piergiorgio Napoli, Anna Antonelli, Guido Mastroianni, Claudio Maria Sernia, Sabina J Clin Med Article Objective: The risk of reinfection with SARS-CoV-2 has been rapidly increased with the circulation of concerns about variants. So, the aim of our study was to evaluate the factors that increase the risk of this reinfection in healthcare workers compared to those who have never been positive and those who have had only one positivity. Methods: A case-control study was carried out at the Teaching Hospital Policlinico Umberto I in Rome, Sapienza University of Rome, in the period between 6 March 2020 and 3 June 2022. Cases are healthcare workers who have developed a reinfection with the SARS-CoV-2 virus, while controls were either healthcare workers who tested positive once or those who have never tested positive for SARS-CoV-2. Results: 134 cases and 267 controls were recruited. Female gender is associated with a higher odds of developing reinfection (OR: 2.42; 95% CI: 1.38–4.25). Moreover, moderate or high alcohol consumption is associated with higher odds of reinfection (OR: 1.49; 95% CI: 1.19–1.87). Diabetes is also associated with higher odds of reinfection (OR: 3.45; 95% CI: 1.41–8.46). Finally, subjects with increased red blood cell counts have higher odds of reinfection (OR: 1.69; 95% CI: 1.21–2.25). Conclusion: From the prevention point of view, these findings indicate that particular attention should be paid to subjects with diabetes mellitus, women and alcoholic drinkers. These results could also suggest that contact tracing represents a fundamental approach model against the SARS-CoV-2 pandemic, together with the health information of participants. MDPI 2023-06-05 /pmc/articles/PMC10253296/ /pubmed/37298055 http://dx.doi.org/10.3390/jcm12113861 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
La Torre, Giuseppe
Paglione, Gianluca
Barone, Lavinia Camilla
Cammalleri, Vittoria
Faticoni, Augusto
Marte, Mattia
Pocino, Roberta Noemi
Previte, Carlo Maria
Bongiovanni, Andrea
Colaprico, Corrado
Ricci, Eleonora
Imeshtari, Valentin
Manai, Maria Vittoria
Shaholli, David
Barletta, Vanessa India
Carluccio, Giovanna
Moretti, Luca
Vezza, Francesca
Volpicelli, Lorenzo
Massetti, Anna Paola
Cinti, Lilia
Roberto, Piergiorgio
Napoli, Anna
Antonelli, Guido
Mastroianni, Claudio Maria
Sernia, Sabina
Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design
title Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design
title_full Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design
title_fullStr Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design
title_full_unstemmed Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design
title_short Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design
title_sort evaluation of the factors associated with reinfections towards sars-cov-2 using a case control design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253296/
https://www.ncbi.nlm.nih.gov/pubmed/37298055
http://dx.doi.org/10.3390/jcm12113861
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