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Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review
Drug coated balloons (DCBs) are currently indicated in guidelines as a first choice option in the management of instant restenosis, whereas their use in de novo lesions is still debated. The concerns raised after the contrasting results of the initial trials with DCBs in de novo lesions have been mo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253316/ https://www.ncbi.nlm.nih.gov/pubmed/37297857 http://dx.doi.org/10.3390/jcm12113662 |
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author | Zilio, Filippo Verdoia, Monica De Angelis, Maria Carmen Zucchelli, Federico Borghesi, Marco Rognoni, Andrea Bonmassari, Roberto |
author_facet | Zilio, Filippo Verdoia, Monica De Angelis, Maria Carmen Zucchelli, Federico Borghesi, Marco Rognoni, Andrea Bonmassari, Roberto |
author_sort | Zilio, Filippo |
collection | PubMed |
description | Drug coated balloons (DCBs) are currently indicated in guidelines as a first choice option in the management of instant restenosis, whereas their use in de novo lesions is still debated. The concerns raised after the contrasting results of the initial trials with DCBs in de novo lesions have been more recently overcome by a larger amount of data confirming their safety and effectiveness as compared to drug-eluting stents (DES), with potentially greater benefits being achieved, especially in particular anatomical settings, as in very small or large vessels and bifurcations, but also in selected subsets of higher-risk patients, where a ‘leave nothing behind’ strategy could offer a reduction of the inflammatory stimulus and thrombotic risk. The present review aims at providing an overview of current available DCB devices and their indications of use based on the results of data achieved so far. |
format | Online Article Text |
id | pubmed-10253316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102533162023-06-10 Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review Zilio, Filippo Verdoia, Monica De Angelis, Maria Carmen Zucchelli, Federico Borghesi, Marco Rognoni, Andrea Bonmassari, Roberto J Clin Med Review Drug coated balloons (DCBs) are currently indicated in guidelines as a first choice option in the management of instant restenosis, whereas their use in de novo lesions is still debated. The concerns raised after the contrasting results of the initial trials with DCBs in de novo lesions have been more recently overcome by a larger amount of data confirming their safety and effectiveness as compared to drug-eluting stents (DES), with potentially greater benefits being achieved, especially in particular anatomical settings, as in very small or large vessels and bifurcations, but also in selected subsets of higher-risk patients, where a ‘leave nothing behind’ strategy could offer a reduction of the inflammatory stimulus and thrombotic risk. The present review aims at providing an overview of current available DCB devices and their indications of use based on the results of data achieved so far. MDPI 2023-05-25 /pmc/articles/PMC10253316/ /pubmed/37297857 http://dx.doi.org/10.3390/jcm12113662 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zilio, Filippo Verdoia, Monica De Angelis, Maria Carmen Zucchelli, Federico Borghesi, Marco Rognoni, Andrea Bonmassari, Roberto Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review |
title | Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review |
title_full | Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review |
title_fullStr | Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review |
title_full_unstemmed | Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review |
title_short | Drug Coated Balloon in the Treatment of De Novo Coronary Artery Disease: A Narrative Review |
title_sort | drug coated balloon in the treatment of de novo coronary artery disease: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253316/ https://www.ncbi.nlm.nih.gov/pubmed/37297857 http://dx.doi.org/10.3390/jcm12113662 |
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