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Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM

Research indicates that adolescents with type 1 diabetes mellitus (T1DM) may develop both metabolic syndrome (MetS) and oxidative stress. The purpose of this study was to test the hypothesis that MetS could potentially affect antioxidant defense parameters. The study recruited adolescents aged 10–17...

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Autores principales: Grabia, Monika, Socha, Katarzyna, Bossowski, Artur, Markiewicz-Żukowska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253328/
https://www.ncbi.nlm.nih.gov/pubmed/37298384
http://dx.doi.org/10.3390/ijms24119428
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author Grabia, Monika
Socha, Katarzyna
Bossowski, Artur
Markiewicz-Żukowska, Renata
author_facet Grabia, Monika
Socha, Katarzyna
Bossowski, Artur
Markiewicz-Żukowska, Renata
author_sort Grabia, Monika
collection PubMed
description Research indicates that adolescents with type 1 diabetes mellitus (T1DM) may develop both metabolic syndrome (MetS) and oxidative stress. The purpose of this study was to test the hypothesis that MetS could potentially affect antioxidant defense parameters. The study recruited adolescents aged 10–17 who had been diagnosed with T1DM, and divided them into two groups: “MetS+” (n = 22), who had been diagnosed with MetS, and “MetS−” (n = 81), who did not have metabolic syndrome. A control group consisting of 60 healthy peers without T1DM was included for comparison. The study examined cardiovascular parameters, such as complete lipid profile and estimated glucose disposal rate (eGDR), as well as markers of antioxidant defense. The results revealed a statistically significant difference between the MetS+ and the MetS− group in terms of total antioxidant status (TAS) (1.186 mmol/L vs. 1.330 mmol/L), and oxidative stress index (OSI) levels (0.666 vs. 0.533). Furthermore, multivariate correspondence analysis identified individuals with HbA1c < 8%; eGDR > 8 mg/kg/min, using either flash or continuous glucose monitoring systems, as MetS− patients. The study also found that eGDR (AUC 0.85, p < 0.001), OSI and HbA1c (AUC 0.71, p < 0.001) markers may be useful for diagnosing the onset of MetS in adolescents with T1DM.
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spelling pubmed-102533282023-06-10 Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM Grabia, Monika Socha, Katarzyna Bossowski, Artur Markiewicz-Żukowska, Renata Int J Mol Sci Article Research indicates that adolescents with type 1 diabetes mellitus (T1DM) may develop both metabolic syndrome (MetS) and oxidative stress. The purpose of this study was to test the hypothesis that MetS could potentially affect antioxidant defense parameters. The study recruited adolescents aged 10–17 who had been diagnosed with T1DM, and divided them into two groups: “MetS+” (n = 22), who had been diagnosed with MetS, and “MetS−” (n = 81), who did not have metabolic syndrome. A control group consisting of 60 healthy peers without T1DM was included for comparison. The study examined cardiovascular parameters, such as complete lipid profile and estimated glucose disposal rate (eGDR), as well as markers of antioxidant defense. The results revealed a statistically significant difference between the MetS+ and the MetS− group in terms of total antioxidant status (TAS) (1.186 mmol/L vs. 1.330 mmol/L), and oxidative stress index (OSI) levels (0.666 vs. 0.533). Furthermore, multivariate correspondence analysis identified individuals with HbA1c < 8%; eGDR > 8 mg/kg/min, using either flash or continuous glucose monitoring systems, as MetS− patients. The study also found that eGDR (AUC 0.85, p < 0.001), OSI and HbA1c (AUC 0.71, p < 0.001) markers may be useful for diagnosing the onset of MetS in adolescents with T1DM. MDPI 2023-05-29 /pmc/articles/PMC10253328/ /pubmed/37298384 http://dx.doi.org/10.3390/ijms24119428 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grabia, Monika
Socha, Katarzyna
Bossowski, Artur
Markiewicz-Żukowska, Renata
Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM
title Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM
title_full Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM
title_fullStr Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM
title_full_unstemmed Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM
title_short Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense System in Youth with T1DM
title_sort metabolic syndrome as a factor of impairment of antioxidant defense system in youth with t1dm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253328/
https://www.ncbi.nlm.nih.gov/pubmed/37298384
http://dx.doi.org/10.3390/ijms24119428
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