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Trends in Photothermal Nanostructures for Antimicrobial Applications

The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to addr...

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Autores principales: Dediu, Violeta, Ghitman, Jana, Gradisteanu Pircalabioru, Gratiela, Chan, Kiat Hwa, Iliescu, Florina Silvia, Iliescu, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253355/
https://www.ncbi.nlm.nih.gov/pubmed/37298326
http://dx.doi.org/10.3390/ijms24119375
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author Dediu, Violeta
Ghitman, Jana
Gradisteanu Pircalabioru, Gratiela
Chan, Kiat Hwa
Iliescu, Florina Silvia
Iliescu, Ciprian
author_facet Dediu, Violeta
Ghitman, Jana
Gradisteanu Pircalabioru, Gratiela
Chan, Kiat Hwa
Iliescu, Florina Silvia
Iliescu, Ciprian
author_sort Dediu, Violeta
collection PubMed
description The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to address drug-resistant bacterial infections in specific, focused, and biologically safe ways. The unique physicochemical properties, biocompatibility, and wide range of adaptability of nanomaterials that exhibit photothermal capability can be employed to develop the next generation of photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review the current state of the art in different functional classes of photothermal antibacterial nanomaterials and strategies to optimise antimicrobial efficiency. The recent achievements and trends in developing photothermally active nanostructures, including plasmonic metals, semiconductors, and carbon-based and organic photothermal polymers, and antibacterial mechanisms of action, including anti-multidrug-resistant bacteria and biofilm removal, will be discussed. Insights into the mechanisms of the photothermal effect and various factors influencing photothermal antimicrobial performance, emphasising the structure–performance relationship, are discussed. We will examine the photothermal agents’ functionalisation for specific bacteria, the effects of the near-infrared light irradiation spectrum, and active photothermal materials for multimodal synergistic-based therapies to minimise side effects and maintain low costs. The most relevant applications are presented, such as antibiofilm formation, biofilm penetration or ablation, and nanomaterial-based infected wound therapy. Practical antibacterial applications employing photothermal antimicrobial agents, alone or in synergistic combination with other nanomaterials, are considered. Existing challenges and limitations in photothermal antimicrobial therapy and future perspectives are presented from the structural, functional, safety, and clinical potential points of view.
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spelling pubmed-102533552023-06-10 Trends in Photothermal Nanostructures for Antimicrobial Applications Dediu, Violeta Ghitman, Jana Gradisteanu Pircalabioru, Gratiela Chan, Kiat Hwa Iliescu, Florina Silvia Iliescu, Ciprian Int J Mol Sci Review The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to address drug-resistant bacterial infections in specific, focused, and biologically safe ways. The unique physicochemical properties, biocompatibility, and wide range of adaptability of nanomaterials that exhibit photothermal capability can be employed to develop the next generation of photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review the current state of the art in different functional classes of photothermal antibacterial nanomaterials and strategies to optimise antimicrobial efficiency. The recent achievements and trends in developing photothermally active nanostructures, including plasmonic metals, semiconductors, and carbon-based and organic photothermal polymers, and antibacterial mechanisms of action, including anti-multidrug-resistant bacteria and biofilm removal, will be discussed. Insights into the mechanisms of the photothermal effect and various factors influencing photothermal antimicrobial performance, emphasising the structure–performance relationship, are discussed. We will examine the photothermal agents’ functionalisation for specific bacteria, the effects of the near-infrared light irradiation spectrum, and active photothermal materials for multimodal synergistic-based therapies to minimise side effects and maintain low costs. The most relevant applications are presented, such as antibiofilm formation, biofilm penetration or ablation, and nanomaterial-based infected wound therapy. Practical antibacterial applications employing photothermal antimicrobial agents, alone or in synergistic combination with other nanomaterials, are considered. Existing challenges and limitations in photothermal antimicrobial therapy and future perspectives are presented from the structural, functional, safety, and clinical potential points of view. MDPI 2023-05-27 /pmc/articles/PMC10253355/ /pubmed/37298326 http://dx.doi.org/10.3390/ijms24119375 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dediu, Violeta
Ghitman, Jana
Gradisteanu Pircalabioru, Gratiela
Chan, Kiat Hwa
Iliescu, Florina Silvia
Iliescu, Ciprian
Trends in Photothermal Nanostructures for Antimicrobial Applications
title Trends in Photothermal Nanostructures for Antimicrobial Applications
title_full Trends in Photothermal Nanostructures for Antimicrobial Applications
title_fullStr Trends in Photothermal Nanostructures for Antimicrobial Applications
title_full_unstemmed Trends in Photothermal Nanostructures for Antimicrobial Applications
title_short Trends in Photothermal Nanostructures for Antimicrobial Applications
title_sort trends in photothermal nanostructures for antimicrobial applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253355/
https://www.ncbi.nlm.nih.gov/pubmed/37298326
http://dx.doi.org/10.3390/ijms24119375
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