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Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers

(1) Background: An open abdomen is a serious medical condition that requires prompt and effective treatment to prevent complications and improve patient outcomes. Negative pressure therapy (NPT) has emerged as a viable therapeutic option for temporary closure of the abdomen, offering several benefit...

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Autores principales: Ciuntu, Bogdan Mihnea, Vintilă, Dan, Tanevski, Adelina, Chiriac, Ștefan, Stefănescu, Gabriela, Abdulan, Irina Mihaela, Balan, Gheorghe G., Veliceasa, Bogdan, Bădulescu, Oana Viola, Ghiga, Gabriela, Fătu, Ana Maria, Georgescu, Andrei, Vascu, Mihai Bogdan, Vasilescu, Alin Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253370/
https://www.ncbi.nlm.nih.gov/pubmed/37297916
http://dx.doi.org/10.3390/jcm12113721
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author Ciuntu, Bogdan Mihnea
Vintilă, Dan
Tanevski, Adelina
Chiriac, Ștefan
Stefănescu, Gabriela
Abdulan, Irina Mihaela
Balan, Gheorghe G.
Veliceasa, Bogdan
Bădulescu, Oana Viola
Ghiga, Gabriela
Fătu, Ana Maria
Georgescu, Andrei
Vascu, Mihai Bogdan
Vasilescu, Alin Mihai
author_facet Ciuntu, Bogdan Mihnea
Vintilă, Dan
Tanevski, Adelina
Chiriac, Ștefan
Stefănescu, Gabriela
Abdulan, Irina Mihaela
Balan, Gheorghe G.
Veliceasa, Bogdan
Bădulescu, Oana Viola
Ghiga, Gabriela
Fătu, Ana Maria
Georgescu, Andrei
Vascu, Mihai Bogdan
Vasilescu, Alin Mihai
author_sort Ciuntu, Bogdan Mihnea
collection PubMed
description (1) Background: An open abdomen is a serious medical condition that requires prompt and effective treatment to prevent complications and improve patient outcomes. Negative pressure therapy (NPT) has emerged as a viable therapeutic option for temporary closure of the abdomen, offering several benefits over traditional methods. (2) Methods: We included 15 patients with pancreatitis who were hospitalized in the I–II Surgery Clinic of the Emergency County Hospital “St. Spiridon” from Iasi, Romania, between 2011–2018 and received NPT. (3) Results: Preoperatively, the mean IAP level was 28.62 mmHg, decreasing significantly postoperatively to 21.31 mmHg. The mean level of the highest IAP value recorded in pancreatitis patients treated with VAC did not differ significantly by lethality (30.31 vs. 28.50; p = 0.810). In vacuum-treated pancreatitis patients with a IAP level > 12, the probability of survival dropped below 50% during the first 7 days of stay in the ICU, so that after 20 days the probability of survival was approximately 20%. IAP enters the determinism of surgery with a sensitivity of 92.3% and a specificity of 99%, the cut-off value of IAP being 15 mmHg. (4) Conclusions: The timing of surgical decompression in abdominal compartment syndrome is very important. Consequently, it is vital to identify a parameter, easy to measure, within the reach of any clinician, so that the indication for surgical intervention can be made judiciously and without delay.
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spelling pubmed-102533702023-06-10 Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers Ciuntu, Bogdan Mihnea Vintilă, Dan Tanevski, Adelina Chiriac, Ștefan Stefănescu, Gabriela Abdulan, Irina Mihaela Balan, Gheorghe G. Veliceasa, Bogdan Bădulescu, Oana Viola Ghiga, Gabriela Fătu, Ana Maria Georgescu, Andrei Vascu, Mihai Bogdan Vasilescu, Alin Mihai J Clin Med Article (1) Background: An open abdomen is a serious medical condition that requires prompt and effective treatment to prevent complications and improve patient outcomes. Negative pressure therapy (NPT) has emerged as a viable therapeutic option for temporary closure of the abdomen, offering several benefits over traditional methods. (2) Methods: We included 15 patients with pancreatitis who were hospitalized in the I–II Surgery Clinic of the Emergency County Hospital “St. Spiridon” from Iasi, Romania, between 2011–2018 and received NPT. (3) Results: Preoperatively, the mean IAP level was 28.62 mmHg, decreasing significantly postoperatively to 21.31 mmHg. The mean level of the highest IAP value recorded in pancreatitis patients treated with VAC did not differ significantly by lethality (30.31 vs. 28.50; p = 0.810). In vacuum-treated pancreatitis patients with a IAP level > 12, the probability of survival dropped below 50% during the first 7 days of stay in the ICU, so that after 20 days the probability of survival was approximately 20%. IAP enters the determinism of surgery with a sensitivity of 92.3% and a specificity of 99%, the cut-off value of IAP being 15 mmHg. (4) Conclusions: The timing of surgical decompression in abdominal compartment syndrome is very important. Consequently, it is vital to identify a parameter, easy to measure, within the reach of any clinician, so that the indication for surgical intervention can be made judiciously and without delay. MDPI 2023-05-28 /pmc/articles/PMC10253370/ /pubmed/37297916 http://dx.doi.org/10.3390/jcm12113721 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ciuntu, Bogdan Mihnea
Vintilă, Dan
Tanevski, Adelina
Chiriac, Ștefan
Stefănescu, Gabriela
Abdulan, Irina Mihaela
Balan, Gheorghe G.
Veliceasa, Bogdan
Bădulescu, Oana Viola
Ghiga, Gabriela
Fătu, Ana Maria
Georgescu, Andrei
Vascu, Mihai Bogdan
Vasilescu, Alin Mihai
Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers
title Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers
title_full Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers
title_fullStr Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers
title_full_unstemmed Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers
title_short Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy System: Influence of Laboratory Markers
title_sort severe acute pancreatitis treated with negative pressure wound therapy system: influence of laboratory markers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253370/
https://www.ncbi.nlm.nih.gov/pubmed/37297916
http://dx.doi.org/10.3390/jcm12113721
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