Cargando…

Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances

One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Golub, Aniela, Ordak, Michal, Nasierowski, Tadeusz, Bujalska-Zadrozny, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253383/
https://www.ncbi.nlm.nih.gov/pubmed/37298365
http://dx.doi.org/10.3390/ijms24119413
_version_ 1785056392895266816
author Golub, Aniela
Ordak, Michal
Nasierowski, Tadeusz
Bujalska-Zadrozny, Magdalena
author_facet Golub, Aniela
Ordak, Michal
Nasierowski, Tadeusz
Bujalska-Zadrozny, Magdalena
author_sort Golub, Aniela
collection PubMed
description One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. The aim of this manuscript was to review three advanced markers of hepatotoxicity in psychiatry, namely, osteopontin (OPN), high-mobility group box 1 protein (HMGB1) and glutathione dehydrogenase (GDH, GLDH), and, on this basis, to identify recommendations that should be included in future studies in patients abusing NPSs. This will make it possible to determine whether NPSs do indeed have a hepatotoxic effect or whether other factors, such as additional substances taken or hepatitis C virus (HCV) infection, are responsible. NPS abusers are at particular risk of HCV infection, and for this reason, it is all the more important to determine what factors actually show a hepatotoxic effect in them.
format Online
Article
Text
id pubmed-10253383
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102533832023-06-10 Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances Golub, Aniela Ordak, Michal Nasierowski, Tadeusz Bujalska-Zadrozny, Magdalena Int J Mol Sci Review One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. The aim of this manuscript was to review three advanced markers of hepatotoxicity in psychiatry, namely, osteopontin (OPN), high-mobility group box 1 protein (HMGB1) and glutathione dehydrogenase (GDH, GLDH), and, on this basis, to identify recommendations that should be included in future studies in patients abusing NPSs. This will make it possible to determine whether NPSs do indeed have a hepatotoxic effect or whether other factors, such as additional substances taken or hepatitis C virus (HCV) infection, are responsible. NPS abusers are at particular risk of HCV infection, and for this reason, it is all the more important to determine what factors actually show a hepatotoxic effect in them. MDPI 2023-05-28 /pmc/articles/PMC10253383/ /pubmed/37298365 http://dx.doi.org/10.3390/ijms24119413 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Golub, Aniela
Ordak, Michal
Nasierowski, Tadeusz
Bujalska-Zadrozny, Magdalena
Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
title Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
title_full Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
title_fullStr Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
title_full_unstemmed Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
title_short Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
title_sort advanced biomarkers of hepatotoxicity in psychiatry: a narrative review and recommendations for new psychoactive substances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253383/
https://www.ncbi.nlm.nih.gov/pubmed/37298365
http://dx.doi.org/10.3390/ijms24119413
work_keys_str_mv AT golubaniela advancedbiomarkersofhepatotoxicityinpsychiatryanarrativereviewandrecommendationsfornewpsychoactivesubstances
AT ordakmichal advancedbiomarkersofhepatotoxicityinpsychiatryanarrativereviewandrecommendationsfornewpsychoactivesubstances
AT nasierowskitadeusz advancedbiomarkersofhepatotoxicityinpsychiatryanarrativereviewandrecommendationsfornewpsychoactivesubstances
AT bujalskazadroznymagdalena advancedbiomarkersofhepatotoxicityinpsychiatryanarrativereviewandrecommendationsfornewpsychoactivesubstances