Investigation of Flavonoid Scaffolds as DAX1 Inhibitors against Ewing Sarcoma through Pharmacoinformatic and Dynamic Simulation Studies

Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX1) is an orphan nuclear receptor encoded by the NR0B1 gene. The functional study showed that DAX1 is a physiologically significant target for EWS/FLI1-mediated oncogenesis, particularly Ewing Sarcoma (ES)....

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Detalles Bibliográficos
Autores principales: Yasir, Muhammad, Park, Jinyoung, Han, Eun-Taek, Park, Won Sun, Han, Jin-Hee, Kwon, Yong-Soo, Lee, Hee-Jae, Hassan, Mubashir, Kloczkowski, Andrzej, Chun, Wanjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253386/
https://www.ncbi.nlm.nih.gov/pubmed/37298283
http://dx.doi.org/10.3390/ijms24119332

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