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Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance
Ovarian cancer (OC) is one of the deadliest gynecological cancers, largely due to the fast development of metastasis and drug resistance. The immune system is a critical component of the OC tumor microenvironment (TME) and immune cells such as T cells, NK cells, and dendritic cells (DC) play a key r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253437/ https://www.ncbi.nlm.nih.gov/pubmed/37298230 http://dx.doi.org/10.3390/ijms24119279 |
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author | Pankowska, Katarzyna Aneta Będkowska, Grażyna Ewa Chociej-Stypułkowska, Joanna Rusak, Małgorzata Dąbrowska, Milena Osada, Joanna |
author_facet | Pankowska, Katarzyna Aneta Będkowska, Grażyna Ewa Chociej-Stypułkowska, Joanna Rusak, Małgorzata Dąbrowska, Milena Osada, Joanna |
author_sort | Pankowska, Katarzyna Aneta |
collection | PubMed |
description | Ovarian cancer (OC) is one of the deadliest gynecological cancers, largely due to the fast development of metastasis and drug resistance. The immune system is a critical component of the OC tumor microenvironment (TME) and immune cells such as T cells, NK cells, and dendritic cells (DC) play a key role in anti-tumor immunity. However, OC tumor cells are well known for evading immune surveillance by modulating the immune response through various mechanisms. Recruiting immune-suppressive cells such as regulatory T cells (Treg cells), macrophages, or myeloid-derived suppressor cells (MDSC) inhibit the anti-tumor immune response and promote the development and progression of OC. Platelets are also involved in immune evasion by interaction with tumor cells or through the secretion of a variety of growth factors and cytokines to promote tumor growth and angiogenesis. In this review, we discuss the role and contribution of immune cells and platelets in TME. Furthermore, we discuss their potential prognostic significance to help in the early detection of OC and to predict disease outcome. |
format | Online Article Text |
id | pubmed-10253437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102534372023-06-10 Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance Pankowska, Katarzyna Aneta Będkowska, Grażyna Ewa Chociej-Stypułkowska, Joanna Rusak, Małgorzata Dąbrowska, Milena Osada, Joanna Int J Mol Sci Review Ovarian cancer (OC) is one of the deadliest gynecological cancers, largely due to the fast development of metastasis and drug resistance. The immune system is a critical component of the OC tumor microenvironment (TME) and immune cells such as T cells, NK cells, and dendritic cells (DC) play a key role in anti-tumor immunity. However, OC tumor cells are well known for evading immune surveillance by modulating the immune response through various mechanisms. Recruiting immune-suppressive cells such as regulatory T cells (Treg cells), macrophages, or myeloid-derived suppressor cells (MDSC) inhibit the anti-tumor immune response and promote the development and progression of OC. Platelets are also involved in immune evasion by interaction with tumor cells or through the secretion of a variety of growth factors and cytokines to promote tumor growth and angiogenesis. In this review, we discuss the role and contribution of immune cells and platelets in TME. Furthermore, we discuss their potential prognostic significance to help in the early detection of OC and to predict disease outcome. MDPI 2023-05-25 /pmc/articles/PMC10253437/ /pubmed/37298230 http://dx.doi.org/10.3390/ijms24119279 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pankowska, Katarzyna Aneta Będkowska, Grażyna Ewa Chociej-Stypułkowska, Joanna Rusak, Małgorzata Dąbrowska, Milena Osada, Joanna Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance |
title | Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance |
title_full | Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance |
title_fullStr | Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance |
title_full_unstemmed | Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance |
title_short | Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance |
title_sort | crosstalk of immune cells and platelets in an ovarian cancer microenvironment and their prognostic significance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253437/ https://www.ncbi.nlm.nih.gov/pubmed/37298230 http://dx.doi.org/10.3390/ijms24119279 |
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