Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy

Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabrica...

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Autores principales: Iizuka, Yuki, Manabe, Yoshiyuki, Ooe, Kazuhiro, Toyoshima, Atsushi, Yin, Xiaojie, Haba, Hiromitsu, Kabayama, Kazuya, Fukase, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253442/
https://www.ncbi.nlm.nih.gov/pubmed/37298546
http://dx.doi.org/10.3390/ijms24119593
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author Iizuka, Yuki
Manabe, Yoshiyuki
Ooe, Kazuhiro
Toyoshima, Atsushi
Yin, Xiaojie
Haba, Hiromitsu
Kabayama, Kazuya
Fukase, Koichi
author_facet Iizuka, Yuki
Manabe, Yoshiyuki
Ooe, Kazuhiro
Toyoshima, Atsushi
Yin, Xiaojie
Haba, Hiromitsu
Kabayama, Kazuya
Fukase, Koichi
author_sort Iizuka, Yuki
collection PubMed
description Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver (211)At (α-particle emitter) to the nuclei of cancer cells. The developed (211)At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery.
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spelling pubmed-102534422023-06-10 Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy Iizuka, Yuki Manabe, Yoshiyuki Ooe, Kazuhiro Toyoshima, Atsushi Yin, Xiaojie Haba, Hiromitsu Kabayama, Kazuya Fukase, Koichi Int J Mol Sci Communication Targeted alpha therapy (TAT) has garnered significant interest as an innovative cancer therapy. Owing to their high energy and short range, achieving selective α-particle accumulation in target tumor cells is crucial for obtaining high potency without adverse effects. To meet this demand, we fabricated an innovative radiolabeled antibody, specifically designed to selectively deliver (211)At (α-particle emitter) to the nuclei of cancer cells. The developed (211)At-labeled antibody exhibited a superior effect compared to its conventional counterparts. This study paves the way for organelle-selective drug delivery. MDPI 2023-05-31 /pmc/articles/PMC10253442/ /pubmed/37298546 http://dx.doi.org/10.3390/ijms24119593 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Iizuka, Yuki
Manabe, Yoshiyuki
Ooe, Kazuhiro
Toyoshima, Atsushi
Yin, Xiaojie
Haba, Hiromitsu
Kabayama, Kazuya
Fukase, Koichi
Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
title Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
title_full Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
title_fullStr Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
title_full_unstemmed Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
title_short Exploring a Nuclear-Selective Radioisotope Delivery System for Efficient Targeted Alpha Therapy
title_sort exploring a nuclear-selective radioisotope delivery system for efficient targeted alpha therapy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253442/
https://www.ncbi.nlm.nih.gov/pubmed/37298546
http://dx.doi.org/10.3390/ijms24119593
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