Cargando…

The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression

Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1 (PDZ) domains, participating in multiple signaling pathways and modulating cellular physiology. It has been identified as an oncogene, promoting cancer development, metastasis, and angiogenesis in various carcinom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Kwang-Min, Seo, Eun-Chan, Lee, Jeong-Hyung, Kim, Hyo-Jin, Hwangbo, Cheol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253468/ https://www.ncbi.nlm.nih.gov/pubmed/37298370 http://dx.doi.org/10.3390/ijms24119418

Ejemplares similares

Syntenin: Key player in cancer exosome biogenesis and uptake?
por: Fares, Joanna, et al.
Publicado: (2016)

Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells
por: Kim, Okhwa, et al.
Publicado: (2022)

Heparanase activates the syndecan-syntenin-ALIX exosome pathway
por: Roucourt, Bart, et al.
Publicado: (2015)

Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin
por: Zhang, Yuefei, et al.
Publicado: (2021)

Syntenin mediates SRC function in exosomal cell-to-cell communication
por: Imjeti, Naga Sailaja, et al.
Publicado: (2017)

Syntenin-knock out reduces exosome turnover and viral transduction
por: Kashyap, Rudra, et al.
Publicado: (2021)

Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions
por: Shimada, Tadayuki, et al.
Publicado: (2019)

Anaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1
por: Li, Ruirui, et al.
Publicado: (2023)

Syntenin Is Expressed in Human Follicular Dendritic Cells and Involved in the Activation of Focal Adhesion Kinase
por: Cho, Whajung, et al.
Publicado: (2013)

Checkpoint Kinase 1 (CHK1) Functions as Both a Diagnostic Marker and a Regulator of Epithelial-to-Mesenchymal Transition (EMT) in Triple-Negative Breast Cancer
por: Kim, Hyo-Jin, et al.
Publicado: (2022)

Syntenin is expressed in human gliomas and may correlate with tumor migration
por: Zhong, Dong, et al.
Publicado: (2015)

Mda-9/Syntenin Is Expressed in Uveal Melanoma and Correlates with Metastatic Progression
por: Gangemi, Rosaria, et al.
Publicado: (2012)

Exosomes, Their Biogenesis and Role in Inter-Cellular Communication, Tumor Microenvironment and Cancer Immunotherapy
por: Jella, Kishore Kumar, et al.
Publicado: (2018)

Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells
por: Kashyap, Rudra, et al.
Publicado: (2015)

Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells
por: Tae, Nara, et al.
Publicado: (2017)

Downregulation of stromal syntenin sustains AML development
por: Leblanc, Raphael, et al.
Publicado: (2023)

Editorial On “Exosomes, Their Biogenesis and Role in Inter-Cellular Communication, Tumor Microenvironment and Cancer Immunotherapy”
por: Golubovskaya, Vita, et al.
Publicado: (2020)

Syntenin Regulated by miR-216b Promotes Cancer Progression in Pancreatic Cancer
por: Zu, Fuqiang, et al.
Publicado: (2022)

Composition, Biogenesis, and Role of Exosomes in Tumor Development
por: Moeinzadeh, Leila, et al.
Publicado: (2022)

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes
por: Tschuschke, Max, et al.
Publicado: (2020)

C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells
por: Kim, Hyo-Jin, et al.
Publicado: (2020)

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles
por: Cone, Allaura S., et al.
Publicado: (2020)

Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function
por: Ro, Young-Tae, et al.
Publicado: (2010)

Syntenin regulates melanogenesis via the p38 MAPK pathway
por: Sun, Lijun, et al.
Publicado: (2020)

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo
por: Leblanc, R., et al.
Publicado: (2020)

Toll-like receptor 4 (TLR4): new insight immune and aging
por: Kim, Hyo-Jin, et al.
Publicado: (2023)

The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry
por: Gordón-Alonso, Mónica, et al.
Publicado: (2012)

Syntenin is involved in the bacteria clearance response of kuruma shrimp (Marsupenaeus japonicus)
por: Liu, Qian, et al.
Publicado: (2015)

RAS-stimulated release of exosomal miR-494-3p promotes the osteolytic bone metastasis of breast cancer cells
por: Kim, Okhwa, et al.
Publicado: (2023)

Functional Characterization of Endothelial Cells Differentiated from Porcine Epiblast Stem Cells
por: Shin, Joon-Hong, et al.
Publicado: (2022)

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
por: Pol, Albert, et al.
Publicado: (2014)

Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis
por: Das, Swadesh K., et al.
Publicado: (2016)

Epigenetic regulation of TGF-β-induced EMT by JMJD3/KDM6B histone H3K27 demethylase
por: Lee, Su-Hyun, et al.
Publicado: (2021)

Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection
por: Figueiredo, Barbara C., et al.
Publicado: (2014)

Effects of syndecan-1 on the expression of syntenin and the migration of U251 glioma cells
por: Chen, Jun, et al.
Publicado: (2017)

A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy
por: Yu, Yongsheng, et al.
Publicado: (2019)

Syntenin overexpression in human lung cancer tissue and serum is associated with poor prognosis
por: Luo, Pengyong, et al.
Publicado: (2020)

Biogenesis and Function of T Cell-Derived Exosomes
por: Ventimiglia, Leandro N., et al.
Publicado: (2016)

Current knowledge on exosome biogenesis and release
por: Hessvik, Nina Pettersen, et al.
Publicado: (2017)

Pathogens and Their Effect on Exosome Biogenesis and Composition
por: Jones, Leandra B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vf1p0sji2mts2d4nsq2fidlj22