Cargando…

Therapeutic potential of 1,3,4-oxadiazoles as potential lead compounds for the treatment of Alzheimer's disease

Monoamine oxidase and cholinesterase enzymes are important targets for the treatment of several neurological diseases especially depression, Parkinson disease and Alzheimer's. Here, we report the synthesis and testing of new 1,3,4-oxadiazole derivatives as novel inhibitors of monoamine oxidase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naseem, Saira, Temirak, Ahmed, Imran, Aqeel, Jalil, Saquib, Fatima, Shamool, Taslimi, Parham, Iqbal, Jamshed, Tasleem, Mussarat, Tahir, Muhammad Nawaz, Shafiq, Zahid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253498/ https://www.ncbi.nlm.nih.gov/pubmed/37304812 http://dx.doi.org/10.1039/d3ra01953e

Ejemplares similares

Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives
por: Hanif, Muhammad, et al.
Publicado: (2012)

1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
por: Bala, Suman, et al.
Publicado: (2014)

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2019)

Synthesis, Computational Studies, Antioxidant and Anti-Inflammatory Bio-Evaluation of 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives
por: Rana, Sibghat Mansoor, et al.
Publicado: (2023)

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
por: Glomb, Teresa, et al.
Publicado: (2021)

Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenic Potential of NSAIDs Bearing 1,3,4-Oxadiazole Scaffold
por: Somani, R. R., et al.
Publicado: (2011)

5-Phenyl-1,3,4-oxadiazol-2-amine
por: Song, Man-Man, et al.
Publicado: (2012)

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
por: Glomb, Teresa, et al.
Publicado: (2018)

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction
por: Wang, Qian, et al.
Publicado: (2019)

Ethyl 2-(5-phenyl-1,3,4-oxadiazol-2-ylsulfanyl)acetate
por: Zareef, Muhammad, et al.
Publicado: (2008)

Synthesis and Evaluation of Novel S-alkyl Phthalimide- and S-benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase
por: Khan, Bilal Ahmad, et al.
Publicado: (2022)

Synthesis, molecular docking study and anticancer activity of novel 1,3,4-oxadiazole derivatives as potential tubulin inhibitors
por: Yousef, Tarek A., et al.
Publicado: (2023)

Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors
por: Shehzad, Muhammad Tariq, et al.
Publicado: (2021)

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
por: Aksenov, Alexander V., et al.
Publicado: (2019)

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives
por: Stecoza, Camelia Elena, et al.
Publicado: (2021)

2-[3,4-Dibutoxy-5-(5-phenyl-1,3,4-oxadiazol-2-yl)-2-thienyl]-5-phenyl-1,3,4-oxadiazole
por: Li, Hai-lin, et al.
Publicado: (2008)

Novel 1,3,4-Oxadiazole Derivatives Containing a Cinnamic Acid Moiety as Potential Bactericide for Rice Bacterial Diseases
por: Wang, Shaobo, et al.
Publicado: (2019)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
por: Wang, Jing-Jing, et al.
Publicado: (2022)

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole
por: Cordes, David B., et al.
Publicado: (2011)

Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
por: Bhat, KI, et al.
Publicado: (2011)

Trifluoromethylpyridine 1,3,4-Oxadiazole Derivatives: Emerging Scaffolds as Bacterial Agents
por: Yu, Gang, et al.
Publicado: (2021)

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
por: Rezki, Nadjet, et al.
Publicado: (2015)

Exploring Probenecid Derived 1,3,4-Oxadiazole-Phthalimide Hybrid as α-Amylase Inhibitor: Synthesis, Structural Investigation, and Molecular Modeling
por: Khan, Bilal Ahmad, et al.
Publicado: (2023)

Modular and Computational Access to Innocuous Multistep Metal-Free Synthesis of 1,3,4-Oxadiazoles as Enzyme Inhibitors
por: Umair, Muhammad, et al.
Publicado: (2023)

Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles
por: Nagalakshmi, G.
Publicado: (2008)

5-(4-Methylphenyl)-1,3,4-oxadiazol-2-amine
por: Zheng, Juan, et al.
Publicado: (2012)

2,6-Dimethyl-4-(1,3,4-oxadiazol-2-yl)quinoline
por: Kashaev, Artyom G., et al.
Publicado: (2010)

Synthesis and Biological Evaluation of β-Aroylpropionic acid based 1,3,4-Oxadiazoles
por: Husain, A., et al.
Publicado: (2009)

Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole
por: Wu, Jian, et al.
Publicado: (2013)

Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs
por: Durgashivaprasad, Ega, et al.
Publicado: (2014)

Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives
por: Batool, Majda, et al.
Publicado: (2018)

Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives
por: El Sadek, Mohamed M., et al.
Publicado: (2013)

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment
por: Rasras, Anas J, et al.
Publicado: (2022)

Synthesis of 2,5-Dialkyl-1,3,4-oxadiazoles Bearing Carboxymethylamino Groups
por: Łuczyński, Marcin, et al.
Publicado: (2022)

1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies
por: Hagras, Mohamed, et al.
Publicado: (2021)

Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors
por: Xu, Ting, et al.
Publicado: (2022)

2,5-Bis(5-methylpyrazin-2-yl)-1,3,4-oxadiazole
por: Ju, Yue, et al.
Publicado: (2011)

2,5-Bis(4-methoxyphenyl)-1,3,4-oxadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

2-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl acetate
por: dos Santos, Alexsandro F., et al.
Publicado: (2014)

Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties
por: Xu, Weiming, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7nr9331v893a91auvkbqda5bmh