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Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression
Night shift work has been found to be associated with a higher risk of cardiovascular and cerebrovascular disease. One of the underlying mechanisms seems to be that shift work promotes hypertension, but results have been variable. This cross-sectional study was carried out in a group of internists w...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253532/ https://www.ncbi.nlm.nih.gov/pubmed/37298261 http://dx.doi.org/10.3390/ijms24119309 |
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author | Toffoli, Barbara Tonon, Federica Giudici, Fabiola Ferretti, Tommaso Ghirigato, Elena Contessa, Matilde Francica, Morena Candido, Riccardo Puato, Massimo Grillo, Andrea Fabris, Bruno Bernardi, Stella |
author_facet | Toffoli, Barbara Tonon, Federica Giudici, Fabiola Ferretti, Tommaso Ghirigato, Elena Contessa, Matilde Francica, Morena Candido, Riccardo Puato, Massimo Grillo, Andrea Fabris, Bruno Bernardi, Stella |
author_sort | Toffoli, Barbara |
collection | PubMed |
description | Night shift work has been found to be associated with a higher risk of cardiovascular and cerebrovascular disease. One of the underlying mechanisms seems to be that shift work promotes hypertension, but results have been variable. This cross-sectional study was carried out in a group of internists with the aim of performing a paired analysis of 24 h blood pressure in the same physicians working a day shift and then a night shift, and a paired analysis of clock gene expression after a night of rest and a night of work. Each participant wore an ambulatory blood pressure monitor (ABPM) twice. The first time was for a 24 h period that included a 12 h day shift (08.00–20.00) and a night of rest. The second time was for a 30 h period that included a day of rest, a night shift (20.00–08.00), and a subsequent period of rest (08.00–14.00). Subjects underwent fasting blood sampling twice: after the night of rest and after the night shift. Night shift work significantly increased night systolic blood pressure (SBP), night diastolic blood pressure (DBP), and heart rate (HR) and decreased their respective nocturnal decline. Clock gene expression increased after the night shift. There was a direct association between night blood pressure and clock gene expression. Night shifts lead to an increase in blood pressure, non-dipping status, and circadian rhythm misalignment. Blood pressure is associated with clock genes and circadian rhythm misalignement. |
format | Online Article Text |
id | pubmed-10253532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102535322023-06-10 Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression Toffoli, Barbara Tonon, Federica Giudici, Fabiola Ferretti, Tommaso Ghirigato, Elena Contessa, Matilde Francica, Morena Candido, Riccardo Puato, Massimo Grillo, Andrea Fabris, Bruno Bernardi, Stella Int J Mol Sci Article Night shift work has been found to be associated with a higher risk of cardiovascular and cerebrovascular disease. One of the underlying mechanisms seems to be that shift work promotes hypertension, but results have been variable. This cross-sectional study was carried out in a group of internists with the aim of performing a paired analysis of 24 h blood pressure in the same physicians working a day shift and then a night shift, and a paired analysis of clock gene expression after a night of rest and a night of work. Each participant wore an ambulatory blood pressure monitor (ABPM) twice. The first time was for a 24 h period that included a 12 h day shift (08.00–20.00) and a night of rest. The second time was for a 30 h period that included a day of rest, a night shift (20.00–08.00), and a subsequent period of rest (08.00–14.00). Subjects underwent fasting blood sampling twice: after the night of rest and after the night shift. Night shift work significantly increased night systolic blood pressure (SBP), night diastolic blood pressure (DBP), and heart rate (HR) and decreased their respective nocturnal decline. Clock gene expression increased after the night shift. There was a direct association between night blood pressure and clock gene expression. Night shifts lead to an increase in blood pressure, non-dipping status, and circadian rhythm misalignment. Blood pressure is associated with clock genes and circadian rhythm misalignement. MDPI 2023-05-26 /pmc/articles/PMC10253532/ /pubmed/37298261 http://dx.doi.org/10.3390/ijms24119309 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Toffoli, Barbara Tonon, Federica Giudici, Fabiola Ferretti, Tommaso Ghirigato, Elena Contessa, Matilde Francica, Morena Candido, Riccardo Puato, Massimo Grillo, Andrea Fabris, Bruno Bernardi, Stella Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression |
title | Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression |
title_full | Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression |
title_fullStr | Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression |
title_full_unstemmed | Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression |
title_short | Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression |
title_sort | preliminary study on the effect of a night shift on blood pressure and clock gene expression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253532/ https://www.ncbi.nlm.nih.gov/pubmed/37298261 http://dx.doi.org/10.3390/ijms24119309 |
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