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Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China
Background: The most effective treatment for end-stage liver diseases is liver transplantation, which is impeded by the shortage of donor livers. Split liver transplantation (SLT) is important for addressing the donor liver shortage. However, full-right full-left SLT for two adult recipients is glob...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253538/ https://www.ncbi.nlm.nih.gov/pubmed/37297977 http://dx.doi.org/10.3390/jcm12113782 |
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author | Ding, Limin Yu, Xizhi Zhang, Rui Qian, Junjie Zhang, Wu Wu, Qinchuan Zhou, Lin Yang, Zhe Zheng, Shusen |
author_facet | Ding, Limin Yu, Xizhi Zhang, Rui Qian, Junjie Zhang, Wu Wu, Qinchuan Zhou, Lin Yang, Zhe Zheng, Shusen |
author_sort | Ding, Limin |
collection | PubMed |
description | Background: The most effective treatment for end-stage liver diseases is liver transplantation, which is impeded by the shortage of donor livers. Split liver transplantation (SLT) is important for addressing the donor liver shortage. However, full-right full-left SLT for two adult recipients is globally rarely conducted. This study aimed to investigate the clinical outcomes of this technique. Methods: We retrospectively analyzed the clinical data of 22 recipients who underwent full-right full-left SLT at Shulan (Hangzhou) Hospital between January, 2021 and September, 2022. The graft-to-recipient weight ratio (GRWR), cold ischemia time, operation time, length of the anhepatic phase, intraoperative blood loss, and red blood cell transfusion amount were all analyzed. The differences in liver function recovery after transplantation were compared between the left and right hemiliver groups. The postoperative complications and prognosis of the recipients were also analyzed. Results: The livers of 11 donors were transplanted into 22 adult recipients. The GRWR ranged from 1.16–1.65%, the cold ischemia time was 282.86 ± 134.87 min, the operation time was 371.32 ± 75.36 min, the anhepatic phase lasted 60.73 ± 19.00 min, the intraoperative blood loss was 759.09 ± 316.84 mL, and the red blood cell transfusion amount was 695.45 ± 393.67 mL. No significant difference in the levels of liver function markers, total bilirubin, aspartate aminotransferase, or alanine aminotransferase between left and right hemiliver groups at 1, 3, 5, 7, 14, and 28 d postoperatively was observed (both p > 0.05). One recipient developed bile leakage 10 d after transplantation, which improved with endoscopic retrograde cholangiopancreatography-guided nasobiliary drainage and stent placement. Another developed portal vein thrombosis 12 d after transplantation and underwent portal vein thrombolytic therapy and stenting to restore portal vein blood flow. A color Doppler ultrasound performed 2 d after transplantation revealed hepatic artery thrombosis in one patient, and thrombolytic therapy was administered to restore hepatic artery blood flow. The liver function of other patients recovered quickly after transplantation. Conclusions: Full-right full-left SLT for two adult patients is an efficient way to increase the donor pool. It is safe and feasible with careful donor and recipient selection. Transplant hospitals with highly experienced surgeons in SLT are recommended to promote using full-right full-left SLT for two adult recipients. |
format | Online Article Text |
id | pubmed-10253538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102535382023-06-10 Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China Ding, Limin Yu, Xizhi Zhang, Rui Qian, Junjie Zhang, Wu Wu, Qinchuan Zhou, Lin Yang, Zhe Zheng, Shusen J Clin Med Article Background: The most effective treatment for end-stage liver diseases is liver transplantation, which is impeded by the shortage of donor livers. Split liver transplantation (SLT) is important for addressing the donor liver shortage. However, full-right full-left SLT for two adult recipients is globally rarely conducted. This study aimed to investigate the clinical outcomes of this technique. Methods: We retrospectively analyzed the clinical data of 22 recipients who underwent full-right full-left SLT at Shulan (Hangzhou) Hospital between January, 2021 and September, 2022. The graft-to-recipient weight ratio (GRWR), cold ischemia time, operation time, length of the anhepatic phase, intraoperative blood loss, and red blood cell transfusion amount were all analyzed. The differences in liver function recovery after transplantation were compared between the left and right hemiliver groups. The postoperative complications and prognosis of the recipients were also analyzed. Results: The livers of 11 donors were transplanted into 22 adult recipients. The GRWR ranged from 1.16–1.65%, the cold ischemia time was 282.86 ± 134.87 min, the operation time was 371.32 ± 75.36 min, the anhepatic phase lasted 60.73 ± 19.00 min, the intraoperative blood loss was 759.09 ± 316.84 mL, and the red blood cell transfusion amount was 695.45 ± 393.67 mL. No significant difference in the levels of liver function markers, total bilirubin, aspartate aminotransferase, or alanine aminotransferase between left and right hemiliver groups at 1, 3, 5, 7, 14, and 28 d postoperatively was observed (both p > 0.05). One recipient developed bile leakage 10 d after transplantation, which improved with endoscopic retrograde cholangiopancreatography-guided nasobiliary drainage and stent placement. Another developed portal vein thrombosis 12 d after transplantation and underwent portal vein thrombolytic therapy and stenting to restore portal vein blood flow. A color Doppler ultrasound performed 2 d after transplantation revealed hepatic artery thrombosis in one patient, and thrombolytic therapy was administered to restore hepatic artery blood flow. The liver function of other patients recovered quickly after transplantation. Conclusions: Full-right full-left SLT for two adult patients is an efficient way to increase the donor pool. It is safe and feasible with careful donor and recipient selection. Transplant hospitals with highly experienced surgeons in SLT are recommended to promote using full-right full-left SLT for two adult recipients. MDPI 2023-05-31 /pmc/articles/PMC10253538/ /pubmed/37297977 http://dx.doi.org/10.3390/jcm12113782 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ding, Limin Yu, Xizhi Zhang, Rui Qian, Junjie Zhang, Wu Wu, Qinchuan Zhou, Lin Yang, Zhe Zheng, Shusen Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
title | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
title_full | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
title_fullStr | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
title_full_unstemmed | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
title_short | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
title_sort | full-right full-left split liver transplantation for two adult recipients: a single-center experience in china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253538/ https://www.ncbi.nlm.nih.gov/pubmed/37297977 http://dx.doi.org/10.3390/jcm12113782 |
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