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Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy

Non-infectious uveitis (NIU) can be an early or even the first extra-articular manifestation of systemic rheumatic diseases, or the first one; thus, rheumatologists are often involved in the diagnostic and therapeutic assessment of NIU. We evaluated 130 patients with a diagnosis of NIU who were admi...

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Autores principales: Triggianese, Paola, Fatica, Mauro, Caso, Francesco, Costa, Luisa, D’Antonio, Arianna, Tasso, Marco, Greco, Elisabetta, Conigliaro, Paola, Bergamini, Alberto, Fabiani, Claudia, Cantarini, Luca, Chimenti, Maria Sole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253547/
https://www.ncbi.nlm.nih.gov/pubmed/37298638
http://dx.doi.org/10.3390/ijms24119690
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author Triggianese, Paola
Fatica, Mauro
Caso, Francesco
Costa, Luisa
D’Antonio, Arianna
Tasso, Marco
Greco, Elisabetta
Conigliaro, Paola
Bergamini, Alberto
Fabiani, Claudia
Cantarini, Luca
Chimenti, Maria Sole
author_facet Triggianese, Paola
Fatica, Mauro
Caso, Francesco
Costa, Luisa
D’Antonio, Arianna
Tasso, Marco
Greco, Elisabetta
Conigliaro, Paola
Bergamini, Alberto
Fabiani, Claudia
Cantarini, Luca
Chimenti, Maria Sole
author_sort Triggianese, Paola
collection PubMed
description Non-infectious uveitis (NIU) can be an early or even the first extra-articular manifestation of systemic rheumatic diseases, or the first one; thus, rheumatologists are often involved in the diagnostic and therapeutic assessment of NIU. We evaluated 130 patients with a diagnosis of NIU who were admitted to two Italian rheumatologic clinics (Tor Vergata University Hospital in Rome, and Federico II University in Naples) from January 2018 to December 2021. Anterior uveitis (AU) occurred in 75.4% of patients, followed by posterior uveitis (PU, 21.5%); acute (54.6%) and recurrent (35.4%) NIU were more documented than chronic NIU (10%), and a bilateral involvement was observed in 38.7% of cases. Half of NIU cases were associated with spondyloarthritis (SpA); the remaining were affected by Behçet disease (BD)-related uveitis (13.9%) and idiopathic NIU (9.2%). HLA-B27(+) patients (34.8%) had a higher prevalence of anterior and unilateral NIU (p = 0.005) with acute course (p = 0.04) than HLA-B27(–) patients. On the contrary, HLA-B51(+) patients (19.6%) had mostly PU and bilateral NIU (p < 0.0001) and recurrent course (p = 0.04) than HLA-B51(–) patients. At the first rheumatologic referral, 117 patients (90%) received systemic treatments. Findings from this study demonstrate that rheumatologic referral has a pivotal role in the diagnostic work-up of NIU and may dramatically influence NIU-treatment strategies.
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spelling pubmed-102535472023-06-10 Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy Triggianese, Paola Fatica, Mauro Caso, Francesco Costa, Luisa D’Antonio, Arianna Tasso, Marco Greco, Elisabetta Conigliaro, Paola Bergamini, Alberto Fabiani, Claudia Cantarini, Luca Chimenti, Maria Sole Int J Mol Sci Article Non-infectious uveitis (NIU) can be an early or even the first extra-articular manifestation of systemic rheumatic diseases, or the first one; thus, rheumatologists are often involved in the diagnostic and therapeutic assessment of NIU. We evaluated 130 patients with a diagnosis of NIU who were admitted to two Italian rheumatologic clinics (Tor Vergata University Hospital in Rome, and Federico II University in Naples) from January 2018 to December 2021. Anterior uveitis (AU) occurred in 75.4% of patients, followed by posterior uveitis (PU, 21.5%); acute (54.6%) and recurrent (35.4%) NIU were more documented than chronic NIU (10%), and a bilateral involvement was observed in 38.7% of cases. Half of NIU cases were associated with spondyloarthritis (SpA); the remaining were affected by Behçet disease (BD)-related uveitis (13.9%) and idiopathic NIU (9.2%). HLA-B27(+) patients (34.8%) had a higher prevalence of anterior and unilateral NIU (p = 0.005) with acute course (p = 0.04) than HLA-B27(–) patients. On the contrary, HLA-B51(+) patients (19.6%) had mostly PU and bilateral NIU (p < 0.0001) and recurrent course (p = 0.04) than HLA-B51(–) patients. At the first rheumatologic referral, 117 patients (90%) received systemic treatments. Findings from this study demonstrate that rheumatologic referral has a pivotal role in the diagnostic work-up of NIU and may dramatically influence NIU-treatment strategies. MDPI 2023-06-02 /pmc/articles/PMC10253547/ /pubmed/37298638 http://dx.doi.org/10.3390/ijms24119690 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Triggianese, Paola
Fatica, Mauro
Caso, Francesco
Costa, Luisa
D’Antonio, Arianna
Tasso, Marco
Greco, Elisabetta
Conigliaro, Paola
Bergamini, Alberto
Fabiani, Claudia
Cantarini, Luca
Chimenti, Maria Sole
Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy
title Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy
title_full Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy
title_fullStr Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy
title_full_unstemmed Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy
title_short Rheumatologist’s Perspective on Non-Infectious Uveitis: Patterns from Tertiary Referral Rheumatologic Clinics in Italy
title_sort rheumatologist’s perspective on non-infectious uveitis: patterns from tertiary referral rheumatologic clinics in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253547/
https://www.ncbi.nlm.nih.gov/pubmed/37298638
http://dx.doi.org/10.3390/ijms24119690
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