Cargando…

Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study

Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaillard, Martin, Razafinimanana, Meva, Challine, Alexandre, Araujo, Raphael L. C., Libé, Rossella, Sibony, Mathilde, Barat, Maxime, Bertherat, Jérôme, Dousset, Bertrand, Fuks, David, Gaujoux, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253560/
https://www.ncbi.nlm.nih.gov/pubmed/37297891
http://dx.doi.org/10.3390/jcm12113698
_version_ 1785056435217891328
author Gaillard, Martin
Razafinimanana, Meva
Challine, Alexandre
Araujo, Raphael L. C.
Libé, Rossella
Sibony, Mathilde
Barat, Maxime
Bertherat, Jérôme
Dousset, Bertrand
Fuks, David
Gaujoux, Sebastien
author_facet Gaillard, Martin
Razafinimanana, Meva
Challine, Alexandre
Araujo, Raphael L. C.
Libé, Rossella
Sibony, Mathilde
Barat, Maxime
Bertherat, Jérôme
Dousset, Bertrand
Fuks, David
Gaujoux, Sebastien
author_sort Gaillard, Martin
collection PubMed
description Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups (p = 0.166) but 3-year disease-free survival was in favor of OA (p = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC.
format Online
Article
Text
id pubmed-10253560
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102535602023-06-10 Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study Gaillard, Martin Razafinimanana, Meva Challine, Alexandre Araujo, Raphael L. C. Libé, Rossella Sibony, Mathilde Barat, Maxime Bertherat, Jérôme Dousset, Bertrand Fuks, David Gaujoux, Sebastien J Clin Med Article Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups (p = 0.166) but 3-year disease-free survival was in favor of OA (p = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC. MDPI 2023-05-26 /pmc/articles/PMC10253560/ /pubmed/37297891 http://dx.doi.org/10.3390/jcm12113698 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gaillard, Martin
Razafinimanana, Meva
Challine, Alexandre
Araujo, Raphael L. C.
Libé, Rossella
Sibony, Mathilde
Barat, Maxime
Bertherat, Jérôme
Dousset, Bertrand
Fuks, David
Gaujoux, Sebastien
Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
title Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
title_full Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
title_fullStr Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
title_full_unstemmed Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
title_short Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
title_sort laparoscopic or open adrenalectomy for stage i–ii adrenocortical carcinoma: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253560/
https://www.ncbi.nlm.nih.gov/pubmed/37297891
http://dx.doi.org/10.3390/jcm12113698
work_keys_str_mv AT gaillardmartin laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT razafinimananameva laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT challinealexandre laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT araujoraphaellc laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT liberossella laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT sibonymathilde laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT baratmaxime laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT bertheratjerome laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT doussetbertrand laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT fuksdavid laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy
AT gaujouxsebastien laparoscopicoropenadrenalectomyforstageiiiadrenocorticalcarcinomaaretrospectivestudy