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Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253560/ https://www.ncbi.nlm.nih.gov/pubmed/37297891 http://dx.doi.org/10.3390/jcm12113698 |
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author | Gaillard, Martin Razafinimanana, Meva Challine, Alexandre Araujo, Raphael L. C. Libé, Rossella Sibony, Mathilde Barat, Maxime Bertherat, Jérôme Dousset, Bertrand Fuks, David Gaujoux, Sebastien |
author_facet | Gaillard, Martin Razafinimanana, Meva Challine, Alexandre Araujo, Raphael L. C. Libé, Rossella Sibony, Mathilde Barat, Maxime Bertherat, Jérôme Dousset, Bertrand Fuks, David Gaujoux, Sebastien |
author_sort | Gaillard, Martin |
collection | PubMed |
description | Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups (p = 0.166) but 3-year disease-free survival was in favor of OA (p = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC. |
format | Online Article Text |
id | pubmed-10253560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102535602023-06-10 Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study Gaillard, Martin Razafinimanana, Meva Challine, Alexandre Araujo, Raphael L. C. Libé, Rossella Sibony, Mathilde Barat, Maxime Bertherat, Jérôme Dousset, Bertrand Fuks, David Gaujoux, Sebastien J Clin Med Article Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I–II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups (p = 0.166) but 3-year disease-free survival was in favor of OA (p = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC. MDPI 2023-05-26 /pmc/articles/PMC10253560/ /pubmed/37297891 http://dx.doi.org/10.3390/jcm12113698 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gaillard, Martin Razafinimanana, Meva Challine, Alexandre Araujo, Raphael L. C. Libé, Rossella Sibony, Mathilde Barat, Maxime Bertherat, Jérôme Dousset, Bertrand Fuks, David Gaujoux, Sebastien Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
title | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
title_full | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
title_fullStr | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
title_full_unstemmed | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
title_short | Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study |
title_sort | laparoscopic or open adrenalectomy for stage i–ii adrenocortical carcinoma: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253560/ https://www.ncbi.nlm.nih.gov/pubmed/37297891 http://dx.doi.org/10.3390/jcm12113698 |
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