DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Although the APOBEC3 family of single-stranded DNA cytosine deaminases is well-known for its antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3′s signature single-base substitutions, C-to-T and C-to-G in TCA and TCT motifs, are evident...

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Detalles Bibliográficos
Autores principales: Naumann, Jordan A., Argyris, Prokopios P., Carpenter, Michael A., Gupta, Harshita B., Chen, Yanjun, Temiz, Nuri A., Zhou, Yufan, Durfee, Cameron, Proehl, Joshua, Koniar, Brenda L., Conticello, Silvestro G., Largaespada, David A., Brown, William L., Aihara, Hideki, Vogel, Rachel I., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253583/
https://www.ncbi.nlm.nih.gov/pubmed/37298259
http://dx.doi.org/10.3390/ijms24119305

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