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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects

Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarker...

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Autores principales: Radulska, Adrianna, Pelikant-Małecka, Iwona, Jendernalik, Kamila, Dobrucki, Iwona T., Kalinowski, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253645/
https://www.ncbi.nlm.nih.gov/pubmed/37298466
http://dx.doi.org/10.3390/ijms24119507
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author Radulska, Adrianna
Pelikant-Małecka, Iwona
Jendernalik, Kamila
Dobrucki, Iwona T.
Kalinowski, Leszek
author_facet Radulska, Adrianna
Pelikant-Małecka, Iwona
Jendernalik, Kamila
Dobrucki, Iwona T.
Kalinowski, Leszek
author_sort Radulska, Adrianna
collection PubMed
description Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs.
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spelling pubmed-102536452023-06-10 Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects Radulska, Adrianna Pelikant-Małecka, Iwona Jendernalik, Kamila Dobrucki, Iwona T. Kalinowski, Leszek Int J Mol Sci Review Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs. MDPI 2023-05-30 /pmc/articles/PMC10253645/ /pubmed/37298466 http://dx.doi.org/10.3390/ijms24119507 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Radulska, Adrianna
Pelikant-Małecka, Iwona
Jendernalik, Kamila
Dobrucki, Iwona T.
Kalinowski, Leszek
Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
title Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
title_full Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
title_fullStr Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
title_full_unstemmed Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
title_short Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
title_sort proteomic and metabolomic changes in psoriasis preclinical and clinical aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253645/
https://www.ncbi.nlm.nih.gov/pubmed/37298466
http://dx.doi.org/10.3390/ijms24119507
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