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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarker...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253645/ https://www.ncbi.nlm.nih.gov/pubmed/37298466 http://dx.doi.org/10.3390/ijms24119507 |
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author | Radulska, Adrianna Pelikant-Małecka, Iwona Jendernalik, Kamila Dobrucki, Iwona T. Kalinowski, Leszek |
author_facet | Radulska, Adrianna Pelikant-Małecka, Iwona Jendernalik, Kamila Dobrucki, Iwona T. Kalinowski, Leszek |
author_sort | Radulska, Adrianna |
collection | PubMed |
description | Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs. |
format | Online Article Text |
id | pubmed-10253645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102536452023-06-10 Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects Radulska, Adrianna Pelikant-Małecka, Iwona Jendernalik, Kamila Dobrucki, Iwona T. Kalinowski, Leszek Int J Mol Sci Review Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs. MDPI 2023-05-30 /pmc/articles/PMC10253645/ /pubmed/37298466 http://dx.doi.org/10.3390/ijms24119507 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Radulska, Adrianna Pelikant-Małecka, Iwona Jendernalik, Kamila Dobrucki, Iwona T. Kalinowski, Leszek Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
title | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
title_full | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
title_fullStr | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
title_full_unstemmed | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
title_short | Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects |
title_sort | proteomic and metabolomic changes in psoriasis preclinical and clinical aspects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253645/ https://www.ncbi.nlm.nih.gov/pubmed/37298466 http://dx.doi.org/10.3390/ijms24119507 |
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