Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer

MicroRNAs (miRNAs) have gained a prominent role as biomarkers in prostate cancer (PCa). Our study aimed to evaluate the potential suppressive effect of miR-137 in a model of advanced PCa with and without diet-induced hypercholesterolemia. In vitro, PC-3 cells were treated with 50 pmol of mimic miR-1...

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Detalles Bibliográficos
Autores principales: Pimenta, Ruan, Mioshi, Carolina Mie, Gonçalves, Guilherme L., Candido, Patrícia, Camargo, Juliana A., Guimarães, Vanessa R., Chiovatto, Caroline, Ghazarian, Vitória, Romão, Poliana, da Silva, Karina Serafim, dos Santos, Gabriel A., Silva, Iran A., Srougi, Miguel, Nahas, William C., Leite, Kátia R., Viana, Nayara I., Reis, Sabrina T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253647/
https://www.ncbi.nlm.nih.gov/pubmed/37298588
http://dx.doi.org/10.3390/ijms24119633

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