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Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review
The paucity of studies available in the literature on brain tumors demonstrates that liquid biopsy (LB) is not currently applied for central nervous system (CNS) cancers. The purpose of this systematic review focused on the application of machine learning (ML) to LB for brain tumors to provide pract...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253654/ https://www.ncbi.nlm.nih.gov/pubmed/37298673 http://dx.doi.org/10.3390/ijms24119723 |
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author | Menna, Grazia Piaser Guerrato, Giacomo Bilgin, Lal Ceccarelli, Giovanni Maria Olivi, Alessandro Della Pepa, Giuseppe Maria |
author_facet | Menna, Grazia Piaser Guerrato, Giacomo Bilgin, Lal Ceccarelli, Giovanni Maria Olivi, Alessandro Della Pepa, Giuseppe Maria |
author_sort | Menna, Grazia |
collection | PubMed |
description | The paucity of studies available in the literature on brain tumors demonstrates that liquid biopsy (LB) is not currently applied for central nervous system (CNS) cancers. The purpose of this systematic review focused on the application of machine learning (ML) to LB for brain tumors to provide practical guidance for neurosurgeons to understand the state-of-the-art practices and open challenges. The herein presented study was conducted in accordance with the PRISMA-P (preferred reporting items for systematic review and meta-analysis protocols) guidelines. An online literature search was launched on PubMed/Medline, Scopus, and Web of Science databases using the following query: “((Liquid biopsy) AND (Glioblastoma OR Brain tumor) AND (Machine learning OR Artificial Intelligence))”. The last database search was conducted in April 2023. Upon the full-text review, 14 articles were included in the study. These were then divided into two subgroups: those dealing with applications of machine learning to liquid biopsy in the field of brain tumors, which is the main aim of this review (n = 8); and those dealing with applications of machine learning to liquid biopsy in the diagnosis of other tumors (n = 6). Although studies on the application of ML to LB in the field of brain tumors are still in their infancy, the rapid development of new techniques, as evidenced by the increase in publications on the subject in the past two years, may in the future allow for rapid, accurate, and noninvasive analysis of tumor data. Thus making it possible to identify key features in the LB samples that are associated with the presence of a brain tumor. These features could then be used by doctors for disease monitoring and treatment planning. |
format | Online Article Text |
id | pubmed-10253654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102536542023-06-10 Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review Menna, Grazia Piaser Guerrato, Giacomo Bilgin, Lal Ceccarelli, Giovanni Maria Olivi, Alessandro Della Pepa, Giuseppe Maria Int J Mol Sci Review The paucity of studies available in the literature on brain tumors demonstrates that liquid biopsy (LB) is not currently applied for central nervous system (CNS) cancers. The purpose of this systematic review focused on the application of machine learning (ML) to LB for brain tumors to provide practical guidance for neurosurgeons to understand the state-of-the-art practices and open challenges. The herein presented study was conducted in accordance with the PRISMA-P (preferred reporting items for systematic review and meta-analysis protocols) guidelines. An online literature search was launched on PubMed/Medline, Scopus, and Web of Science databases using the following query: “((Liquid biopsy) AND (Glioblastoma OR Brain tumor) AND (Machine learning OR Artificial Intelligence))”. The last database search was conducted in April 2023. Upon the full-text review, 14 articles were included in the study. These were then divided into two subgroups: those dealing with applications of machine learning to liquid biopsy in the field of brain tumors, which is the main aim of this review (n = 8); and those dealing with applications of machine learning to liquid biopsy in the diagnosis of other tumors (n = 6). Although studies on the application of ML to LB in the field of brain tumors are still in their infancy, the rapid development of new techniques, as evidenced by the increase in publications on the subject in the past two years, may in the future allow for rapid, accurate, and noninvasive analysis of tumor data. Thus making it possible to identify key features in the LB samples that are associated with the presence of a brain tumor. These features could then be used by doctors for disease monitoring and treatment planning. MDPI 2023-06-03 /pmc/articles/PMC10253654/ /pubmed/37298673 http://dx.doi.org/10.3390/ijms24119723 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Menna, Grazia Piaser Guerrato, Giacomo Bilgin, Lal Ceccarelli, Giovanni Maria Olivi, Alessandro Della Pepa, Giuseppe Maria Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review |
title | Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review |
title_full | Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review |
title_fullStr | Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review |
title_full_unstemmed | Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review |
title_short | Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review |
title_sort | is there a role for machine learning in liquid biopsy for brain tumors? a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253654/ https://www.ncbi.nlm.nih.gov/pubmed/37298673 http://dx.doi.org/10.3390/ijms24119723 |
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