Cargando…

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total bilirubin. Tocilizumab has been reported to induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beaudoin, James J., Clemens, Lara, Miedel, Mark T., Gough, Albert, Zaidi, Fatima, Ramamoorthy, Priya, Wong, Kari E., Sarangarajan, Rangaprasad, Battista, Christina, Shoda, Lisl K. M., Siler, Scott Q., Taylor, D. Lansing, Howell, Brett A., Vernetti, Lawrence A., Yang, Kyunghee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253699/ https://www.ncbi.nlm.nih.gov/pubmed/37298645 http://dx.doi.org/10.3390/ijms24119692

Ejemplares similares

Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System
por: Miedel, Mark T., et al.
Publicado: (2019)

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity
por: Generaux, Grant, et al.
Publicado: (2019)

Applications of the microphysiology systems database for experimental ADME-Tox and disease models
por: Schurdak, Mark, et al.
Publicado: (2020)

Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials
por: Longo, DM, et al.
Publicado: (2017)

Unfolding: H_{ggF} -> WW -> lvlv
por: Haslam, Freya Isobel
Publicado: (2021)

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
por: Vernetti, Lawrence, et al.
Publicado: (2017)

Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
por: Vernetti, Lawrence, et al.
Publicado: (2017)

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses
por: Shoda, Lisl KM, et al.
Publicado: (2017)

Liver microphysiological platforms for drug metabolism applications
por: Kulsharova, Gulsim, et al.
Publicado: (2021)

QST Conference CICG 16 Oct 2017
por: Ordan, Julien Marius
Publicado: (2017)

Liver Microphysiological Systems for Predicting and Evaluating Drug Effects
por: Ribeiro, Alexandre J. S., et al.
Publicado: (2019)

Peer review of the pesticide risk assessment of the active substance Bacillus amyloliquefaciens strain QST 713 (formerly Bacillus subtilis strain QST 713)
por: Anastassiadou, Maria, et al.
Publicado: (2021)

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury
por: Zhou, Yitian, et al.
Publicado: (2019)

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)
por: Murphy, William A., et al.
Publicado: (2022)

Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model
por: Kaden, Tim, et al.
Publicado: (2023)

Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver Characteristics
por: Horiuchi, Shinichiro, et al.
Publicado: (2022)

Bioactivation and covalent binding of halothane to liver macromolecules.
por: Sipes, I G, et al.
Publicado: (1977)

Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk
por: Chen, Wen L.K., et al.
Publicado: (2017)

Study of the Anticancer Potential of Plant Extracts Using Liver Tumor Microphysiological System
por: Farooqi, Hafiz Muhammad Umer, et al.
Publicado: (2022)

Microphysiological systems
por: Hickman, James J., et al.
Publicado: (2019)

Reduction of Mycotoxigenic Fungi Growth and Their Mycotoxin Production by Bacillus subtilis QST 713
por: Bertuzzi, Terenzio, et al.
Publicado: (2022)

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system
por: Wheeler, S E, et al.
Publicado: (2014)

Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
por: Farooqi, Hafiz Muhammad Umer, et al.
Publicado: (2021)

Rare Carbon-Bridged Citrinin Dimers from the Starfish-Derived Symbiotic Fungus Penicillium sp. GGF16-1-2
por: Fan, Hao, et al.
Publicado: (2022)

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
por: Kostrzewski, Tomasz, et al.
Publicado: (2021)

Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation
por: Rubiano, Andrés, et al.
Publicado: (2021)

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
por: Trapecar, Martin, et al.
Publicado: (2021)

QstR-dependent regulation of natural competence and type VI secretion in Vibrio cholerae
por: Jaskólska, Milena, et al.
Publicado: (2018)

Chronic Pain Diagnosis Using Machine Learning, Questionnaires, and QST: A Sensitivity Experiment
por: Santana, Alex Novaes, et al.
Publicado: (2020)

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition
por: Beaudoin, James J., et al.
Publicado: (2023)

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors
por: Woodhead, Jeffrey L., et al.
Publicado: (2017)

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development
por: Mathur, Anurag, et al.
Publicado: (2013)

Overcoming pain thresholds with multilevel models—an example using quantitative sensory testing (QST) data
por: Hirschfeld, Gerrit, et al.
Publicado: (2015)

Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym
por: Longo, Diane M, et al.
Publicado: (2020)

Engineering challenges in microphysiological systems
por: Zhang, Yu Shrike
Publicado: (2017)

A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial
por: Howell, B A, et al.
Publicado: (2014)

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans
por: Bhushan, Abhinav, et al.
Publicado: (2013)

Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application
por: Li, Dan, et al.
Publicado: (2023)

Bilateral Sensory Abnormalities in Patients with Unilateral Neuropathic Pain; A Quantitative Sensory Testing (QST) Study
por: Konopka, Karl-Heinz, et al.
Publicado: (2012)

The added value of bedside examination and screening QST to improve neuropathic pain identification in patients with chronic pain
por: Timmerman, Hans, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mca6c6qlhgucjdoi29kfkfumls