Cargando…
MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment
Myocardial bridging (MB) is the most frequent congenital coronary anomaly characterized by a segment of an epicardial coronary artery that passes through the myocardium. MB is an important cause of myocardial ischemia and is also emerging as a possible cause of myocardial infarction with non-obstruc...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253711/ https://www.ncbi.nlm.nih.gov/pubmed/37297993 http://dx.doi.org/10.3390/jcm12113799 |
_version_ | 1785056471267934208 |
---|---|
author | Rinaldi, Riccardo Princi, Giuseppe La Vecchia, Giulia Bonanni, Alice Chiariello, Giovanni Alfonso Candreva, Alessandro Gragnano, Felice Calabrò, Paolo Crea, Filippo Montone, Rocco A. |
author_facet | Rinaldi, Riccardo Princi, Giuseppe La Vecchia, Giulia Bonanni, Alice Chiariello, Giovanni Alfonso Candreva, Alessandro Gragnano, Felice Calabrò, Paolo Crea, Filippo Montone, Rocco A. |
author_sort | Rinaldi, Riccardo |
collection | PubMed |
description | Myocardial bridging (MB) is the most frequent congenital coronary anomaly characterized by a segment of an epicardial coronary artery that passes through the myocardium. MB is an important cause of myocardial ischemia and is also emerging as a possible cause of myocardial infarction with non-obstructed coronary arteries (MINOCA). There are multiple mechanisms underlying MINOCA in patients with MB (i.e., MB-mediated increased risk of epicardial or microvascular coronary spasm, atherosclerotic plaque disruption and spontaneous coronary artery dissection). The identification of the exact pathogenetic mechanism is crucial in order to establish a patient-tailored therapy. This review provides the most up-to-date evidence regarding the pathophysiology of MINOCA in patients with MB. Moreover, it focuses on the available diagnostic tools that could be implemented at the time of coronary angiography to achieve a pathophysiologic diagnosis. Finally, it focuses on the therapeutic implications associated with the different pathogenetic mechanisms of MINOCA in patients with MB. |
format | Online Article Text |
id | pubmed-10253711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102537112023-06-10 MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment Rinaldi, Riccardo Princi, Giuseppe La Vecchia, Giulia Bonanni, Alice Chiariello, Giovanni Alfonso Candreva, Alessandro Gragnano, Felice Calabrò, Paolo Crea, Filippo Montone, Rocco A. J Clin Med Review Myocardial bridging (MB) is the most frequent congenital coronary anomaly characterized by a segment of an epicardial coronary artery that passes through the myocardium. MB is an important cause of myocardial ischemia and is also emerging as a possible cause of myocardial infarction with non-obstructed coronary arteries (MINOCA). There are multiple mechanisms underlying MINOCA in patients with MB (i.e., MB-mediated increased risk of epicardial or microvascular coronary spasm, atherosclerotic plaque disruption and spontaneous coronary artery dissection). The identification of the exact pathogenetic mechanism is crucial in order to establish a patient-tailored therapy. This review provides the most up-to-date evidence regarding the pathophysiology of MINOCA in patients with MB. Moreover, it focuses on the available diagnostic tools that could be implemented at the time of coronary angiography to achieve a pathophysiologic diagnosis. Finally, it focuses on the therapeutic implications associated with the different pathogenetic mechanisms of MINOCA in patients with MB. MDPI 2023-05-31 /pmc/articles/PMC10253711/ /pubmed/37297993 http://dx.doi.org/10.3390/jcm12113799 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rinaldi, Riccardo Princi, Giuseppe La Vecchia, Giulia Bonanni, Alice Chiariello, Giovanni Alfonso Candreva, Alessandro Gragnano, Felice Calabrò, Paolo Crea, Filippo Montone, Rocco A. MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment |
title | MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment |
title_full | MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment |
title_fullStr | MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment |
title_full_unstemmed | MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment |
title_short | MINOCA Associated with a Myocardial Bridge: Pathogenesis, Diagnosis and Treatment |
title_sort | minoca associated with a myocardial bridge: pathogenesis, diagnosis and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253711/ https://www.ncbi.nlm.nih.gov/pubmed/37297993 http://dx.doi.org/10.3390/jcm12113799 |
work_keys_str_mv | AT rinaldiriccardo minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT princigiuseppe minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT lavecchiagiulia minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT bonannialice minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT chiariellogiovannialfonso minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT candrevaalessandro minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT gragnanofelice minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT calabropaolo minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT creafilippo minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment AT montoneroccoa minocaassociatedwithamyocardialbridgepathogenesisdiagnosisandtreatment |