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A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status

At present, obesity, as a part of metabolic syndrome, represents the leading factor for disability, and is correlated with higher inflammation status, morbidity, and mortality. The purpose of our study is to add new insights to the present body of knowledge regarding the correlations between chronic...

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Autores principales: Ion, Razvan-Marius, Sibianu, Melania, Hutanu, Adina, Beresescu, Felicia Gabriela, Sala, Daniela Tatiana, Flavius, Mocian, Rosca, Ancuta, Constantin, Calin, Scurtu, Alexandra, Moriczi, Renata, Muresan, Mircea Gabriel, Gabriel, Popescu, Niculescu, Raluca, Neagoe, Radu Mircea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253880/
https://www.ncbi.nlm.nih.gov/pubmed/37298013
http://dx.doi.org/10.3390/jcm12113818
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author Ion, Razvan-Marius
Sibianu, Melania
Hutanu, Adina
Beresescu, Felicia Gabriela
Sala, Daniela Tatiana
Flavius, Mocian
Rosca, Ancuta
Constantin, Calin
Scurtu, Alexandra
Moriczi, Renata
Muresan, Mircea Gabriel
Gabriel, Popescu
Niculescu, Raluca
Neagoe, Radu Mircea
author_facet Ion, Razvan-Marius
Sibianu, Melania
Hutanu, Adina
Beresescu, Felicia Gabriela
Sala, Daniela Tatiana
Flavius, Mocian
Rosca, Ancuta
Constantin, Calin
Scurtu, Alexandra
Moriczi, Renata
Muresan, Mircea Gabriel
Gabriel, Popescu
Niculescu, Raluca
Neagoe, Radu Mircea
author_sort Ion, Razvan-Marius
collection PubMed
description At present, obesity, as a part of metabolic syndrome, represents the leading factor for disability, and is correlated with higher inflammation status, morbidity, and mortality. The purpose of our study is to add new insights to the present body of knowledge regarding the correlations between chronic systemic inflammation and severe obesity, which cannot be treated without considering other metabolic syndrome conditions. Biomarkers of high-level chronic inflammation are recognized as important predictors of pro-inflammatory disease. Besides the well-known pro-inflammatory cytokines, such as WBCs (white blood cells), IL-1 (interleukin-1), IL-6 (interleukin-6), TNF-alpha (tumor necrosis factor-alpha), and hsCRP (high-sensitivity C-reactive protein), as well as anti-inflammatory markers, such as adiponectin and systemic inflammation, can be determined by a variety of blood tests as a largely available and inexpensive inflammatory biomarker tool. A few parameters, such as the neutrophil-to-lymphocyte ratio; the level of cholesterol 25-hydroxylase, which is part of the macrophage-enriched metabolic network in adipose tissue; or levels of glutamine, an immune–metabolic regulator in white adipose tissue, are markers that link obesity to inflammation. Through this narrative review, we try to emphasize the influence of the weight-loss process in reducing obesity-related pro-inflammatory status and associated comorbidities. All data from the presented studies report positive results following weight-loss procedures while improving overall health, an effect that lasts over time, as far as the existing research data show.
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spelling pubmed-102538802023-06-10 A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status Ion, Razvan-Marius Sibianu, Melania Hutanu, Adina Beresescu, Felicia Gabriela Sala, Daniela Tatiana Flavius, Mocian Rosca, Ancuta Constantin, Calin Scurtu, Alexandra Moriczi, Renata Muresan, Mircea Gabriel Gabriel, Popescu Niculescu, Raluca Neagoe, Radu Mircea J Clin Med Review At present, obesity, as a part of metabolic syndrome, represents the leading factor for disability, and is correlated with higher inflammation status, morbidity, and mortality. The purpose of our study is to add new insights to the present body of knowledge regarding the correlations between chronic systemic inflammation and severe obesity, which cannot be treated without considering other metabolic syndrome conditions. Biomarkers of high-level chronic inflammation are recognized as important predictors of pro-inflammatory disease. Besides the well-known pro-inflammatory cytokines, such as WBCs (white blood cells), IL-1 (interleukin-1), IL-6 (interleukin-6), TNF-alpha (tumor necrosis factor-alpha), and hsCRP (high-sensitivity C-reactive protein), as well as anti-inflammatory markers, such as adiponectin and systemic inflammation, can be determined by a variety of blood tests as a largely available and inexpensive inflammatory biomarker tool. A few parameters, such as the neutrophil-to-lymphocyte ratio; the level of cholesterol 25-hydroxylase, which is part of the macrophage-enriched metabolic network in adipose tissue; or levels of glutamine, an immune–metabolic regulator in white adipose tissue, are markers that link obesity to inflammation. Through this narrative review, we try to emphasize the influence of the weight-loss process in reducing obesity-related pro-inflammatory status and associated comorbidities. All data from the presented studies report positive results following weight-loss procedures while improving overall health, an effect that lasts over time, as far as the existing research data show. MDPI 2023-06-02 /pmc/articles/PMC10253880/ /pubmed/37298013 http://dx.doi.org/10.3390/jcm12113818 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ion, Razvan-Marius
Sibianu, Melania
Hutanu, Adina
Beresescu, Felicia Gabriela
Sala, Daniela Tatiana
Flavius, Mocian
Rosca, Ancuta
Constantin, Calin
Scurtu, Alexandra
Moriczi, Renata
Muresan, Mircea Gabriel
Gabriel, Popescu
Niculescu, Raluca
Neagoe, Radu Mircea
A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
title A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
title_full A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
title_fullStr A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
title_full_unstemmed A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
title_short A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
title_sort comprehensive summary of the current understanding of the relationship between severe obesity, metabolic syndrome, and inflammatory status
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253880/
https://www.ncbi.nlm.nih.gov/pubmed/37298013
http://dx.doi.org/10.3390/jcm12113818
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