An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes

This review examines the existing knowledge about Ru(II)/(III) ion complexes with a potential application in medicine or pharmacy, which may offer greater potential in cancer chemotherapy than Pt(II) complexes, which are known to cause many side effects. Hence, much attention has been paid to resear...

Descripción completa

Detalles Bibliográficos
Autores principales: Skoczynska, Anna, Lewinski, Andrzej, Pokora, Mateusz, Paneth, Piotr, Budzisz, Elzbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253973/
https://www.ncbi.nlm.nih.gov/pubmed/37298471
http://dx.doi.org/10.3390/ijms24119512
_version_ 1785056533504065536
author Skoczynska, Anna
Lewinski, Andrzej
Pokora, Mateusz
Paneth, Piotr
Budzisz, Elzbieta
author_facet Skoczynska, Anna
Lewinski, Andrzej
Pokora, Mateusz
Paneth, Piotr
Budzisz, Elzbieta
author_sort Skoczynska, Anna
collection PubMed
description This review examines the existing knowledge about Ru(II)/(III) ion complexes with a potential application in medicine or pharmacy, which may offer greater potential in cancer chemotherapy than Pt(II) complexes, which are known to cause many side effects. Hence, much attention has been paid to research on cancer cell lines and clinical trials have been undertaken on ruthenium complexes. In addition to their antitumor activity, ruthenium complexes are under evaluation for other diseases, such as type 2 diabetes, Alzheimer’s disease and HIV. Attempts are also being made to evaluate ruthenium complexes as potential photosensitizers with polypyridine ligands for use in cancer chemotherapy. The review also briefly examines theoretical approaches to studying the interactions of Ru(II)/Ru(III) complexes with biological receptors, which can facilitate the rational design of ruthenium-based drugs.
format Online
Article
Text
id pubmed-10253973
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102539732023-06-10 An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes Skoczynska, Anna Lewinski, Andrzej Pokora, Mateusz Paneth, Piotr Budzisz, Elzbieta Int J Mol Sci Review This review examines the existing knowledge about Ru(II)/(III) ion complexes with a potential application in medicine or pharmacy, which may offer greater potential in cancer chemotherapy than Pt(II) complexes, which are known to cause many side effects. Hence, much attention has been paid to research on cancer cell lines and clinical trials have been undertaken on ruthenium complexes. In addition to their antitumor activity, ruthenium complexes are under evaluation for other diseases, such as type 2 diabetes, Alzheimer’s disease and HIV. Attempts are also being made to evaluate ruthenium complexes as potential photosensitizers with polypyridine ligands for use in cancer chemotherapy. The review also briefly examines theoretical approaches to studying the interactions of Ru(II)/Ru(III) complexes with biological receptors, which can facilitate the rational design of ruthenium-based drugs. MDPI 2023-05-30 /pmc/articles/PMC10253973/ /pubmed/37298471 http://dx.doi.org/10.3390/ijms24119512 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Skoczynska, Anna
Lewinski, Andrzej
Pokora, Mateusz
Paneth, Piotr
Budzisz, Elzbieta
An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes
title An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes
title_full An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes
title_fullStr An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes
title_full_unstemmed An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes
title_short An Overview of the Potential Medicinal and Pharmaceutical Properties of Ru(II)/(III) Complexes
title_sort overview of the potential medicinal and pharmaceutical properties of ru(ii)/(iii) complexes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253973/
https://www.ncbi.nlm.nih.gov/pubmed/37298471
http://dx.doi.org/10.3390/ijms24119512
work_keys_str_mv AT skoczynskaanna anoverviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT lewinskiandrzej anoverviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT pokoramateusz anoverviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT panethpiotr anoverviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT budziszelzbieta anoverviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT skoczynskaanna overviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT lewinskiandrzej overviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT pokoramateusz overviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT panethpiotr overviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes
AT budziszelzbieta overviewofthepotentialmedicinalandpharmaceuticalpropertiesofruiiiiicomplexes

Ejemplares similares