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Smoking Intensity Increases Diaphragm Muscle Injury: A Clinicopathologic Study

Background: Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of p...

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Detalles Bibliográficos
Autores principales: Nucci, Ricardo Aparecido Baptista, Busse, Alexandre Leopold, de Souza, Romeu Rodrigues, Maifrino, Laura Beatriz Mesiano, Pasqualucci, Carlos Augusto, Anaruma, Carlos Alberto, Leite, Renata Elaine Paraizo, Rodriguez, Roberta Diehl, Suemoto, Claudia Kimie, Jacob-Filho, Wilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253982/
https://www.ncbi.nlm.nih.gov/pubmed/37298016
http://dx.doi.org/10.3390/jcm12113823
Descripción
Sumario:Background: Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of postmortem samples. Methods: Subjects were divided into three groups: never-smoker (n = 46); less than 30 pack-years of smoking (n = 12); and more than 30 pack-years of smoking (n = 30). Diaphragm samples were stained with Picrosirius red and hematoxylin and eosin stain for general structure. Results: Participants with more than 30 pack-years of cigarette smoking had a significant increase in adipocytes, blood vessels and collagen deposit, as well as an increase in histopathological alterations. Conclusions: Pack-years of smoking was associated with DIAm injury. However, further clinicopathological studies are needed to confirm our findings.