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Role of SNAREs and Rabs in Myelin Regulation

The myelin sheath is an insulating layer around the nerves of the brain and spinal cord which allows a fast and efficient nerve conduction. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. The myelin sheath is formed by oligodendrocyt...

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Autor principal: Margiotta, Azzurra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254019/
https://www.ncbi.nlm.nih.gov/pubmed/37298723
http://dx.doi.org/10.3390/ijms24119772
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author Margiotta, Azzurra
author_facet Margiotta, Azzurra
author_sort Margiotta, Azzurra
collection PubMed
description The myelin sheath is an insulating layer around the nerves of the brain and spinal cord which allows a fast and efficient nerve conduction. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. The myelin sheath is formed by oligodendrocytes in the central nervous system (CNS) and by Schwann cells in the peripheral nervous system (PNS). The myelin sheath presents a highly organized structure and expands both radially and longitudinally, but in a different way and with a different composition. Myelin alterations determine the onset of several neuropathies, as the electrical signal can be slowed or stopped. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and ras (rat sarcoma)-associated binding proteins (rabs) have been proved to contribute to several aspects regarding the formation of myelin or dysmyelination. Here, I will describe the role of these proteins in regulating membrane trafficking and nerve conduction, myelin biogenesis and maintenance.
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spelling pubmed-102540192023-06-10 Role of SNAREs and Rabs in Myelin Regulation Margiotta, Azzurra Int J Mol Sci Review The myelin sheath is an insulating layer around the nerves of the brain and spinal cord which allows a fast and efficient nerve conduction. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. The myelin sheath is formed by oligodendrocytes in the central nervous system (CNS) and by Schwann cells in the peripheral nervous system (PNS). The myelin sheath presents a highly organized structure and expands both radially and longitudinally, but in a different way and with a different composition. Myelin alterations determine the onset of several neuropathies, as the electrical signal can be slowed or stopped. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and ras (rat sarcoma)-associated binding proteins (rabs) have been proved to contribute to several aspects regarding the formation of myelin or dysmyelination. Here, I will describe the role of these proteins in regulating membrane trafficking and nerve conduction, myelin biogenesis and maintenance. MDPI 2023-06-05 /pmc/articles/PMC10254019/ /pubmed/37298723 http://dx.doi.org/10.3390/ijms24119772 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Margiotta, Azzurra
Role of SNAREs and Rabs in Myelin Regulation
title Role of SNAREs and Rabs in Myelin Regulation
title_full Role of SNAREs and Rabs in Myelin Regulation
title_fullStr Role of SNAREs and Rabs in Myelin Regulation
title_full_unstemmed Role of SNAREs and Rabs in Myelin Regulation
title_short Role of SNAREs and Rabs in Myelin Regulation
title_sort role of snares and rabs in myelin regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254019/
https://www.ncbi.nlm.nih.gov/pubmed/37298723
http://dx.doi.org/10.3390/ijms24119772
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