Cargando…

Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation

The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our...

Descripción completa

Detalles Bibliográficos
Autores principales: Frankowski, Rafał, Kobierecki, Mateusz, Wittczak, Andrzej, Różycka-Kosmalska, Monika, Pietras, Tadeusz, Sipowicz, Kasper, Kosmalski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254034/
https://www.ncbi.nlm.nih.gov/pubmed/37298632
http://dx.doi.org/10.3390/ijms24119677
_version_ 1785056548059348992
author Frankowski, Rafał
Kobierecki, Mateusz
Wittczak, Andrzej
Różycka-Kosmalska, Monika
Pietras, Tadeusz
Sipowicz, Kasper
Kosmalski, Marcin
author_facet Frankowski, Rafał
Kobierecki, Mateusz
Wittczak, Andrzej
Różycka-Kosmalska, Monika
Pietras, Tadeusz
Sipowicz, Kasper
Kosmalski, Marcin
author_sort Frankowski, Rafał
collection PubMed
description The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our primary focus was on examining the role of chronic inflammation as a potential link in the pathogenesis of these diseases and their interconnections. A comprehensive search of the PubMed database using keywords such as “non-alcoholic fatty liver disease”, “type 2 diabetes mellitus”, “chronic inflammation”, “pathogenesis”, and “progression” yielded 177 relevant papers for our analysis. The findings of our study revealed intricate relationships between the pathogenesis of NAFLD and DM2, emphasizing the crucial role of inflammatory processes. These connections involve various molecular functions, including altered signaling pathways, patterns of gene methylation, the expression of related peptides, and up- and downregulation of several genes. Our study is a foundational platform for future research into the intricate relationship between NAFLD and DM2, allowing for a better understanding of the underlying mechanisms and the potential for introducing new treatment standards.
format Online
Article
Text
id pubmed-10254034
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102540342023-06-10 Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation Frankowski, Rafał Kobierecki, Mateusz Wittczak, Andrzej Różycka-Kosmalska, Monika Pietras, Tadeusz Sipowicz, Kasper Kosmalski, Marcin Int J Mol Sci Review The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our primary focus was on examining the role of chronic inflammation as a potential link in the pathogenesis of these diseases and their interconnections. A comprehensive search of the PubMed database using keywords such as “non-alcoholic fatty liver disease”, “type 2 diabetes mellitus”, “chronic inflammation”, “pathogenesis”, and “progression” yielded 177 relevant papers for our analysis. The findings of our study revealed intricate relationships between the pathogenesis of NAFLD and DM2, emphasizing the crucial role of inflammatory processes. These connections involve various molecular functions, including altered signaling pathways, patterns of gene methylation, the expression of related peptides, and up- and downregulation of several genes. Our study is a foundational platform for future research into the intricate relationship between NAFLD and DM2, allowing for a better understanding of the underlying mechanisms and the potential for introducing new treatment standards. MDPI 2023-06-02 /pmc/articles/PMC10254034/ /pubmed/37298632 http://dx.doi.org/10.3390/ijms24119677 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Frankowski, Rafał
Kobierecki, Mateusz
Wittczak, Andrzej
Różycka-Kosmalska, Monika
Pietras, Tadeusz
Sipowicz, Kasper
Kosmalski, Marcin
Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
title Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
title_full Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
title_fullStr Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
title_full_unstemmed Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
title_short Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
title_sort type 2 diabetes mellitus, non-alcoholic fatty liver disease, and metabolic repercussions: the vicious cycle and its interplay with inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254034/
https://www.ncbi.nlm.nih.gov/pubmed/37298632
http://dx.doi.org/10.3390/ijms24119677
work_keys_str_mv AT frankowskirafał type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation
AT kobiereckimateusz type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation
AT wittczakandrzej type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation
AT rozyckakosmalskamonika type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation
AT pietrastadeusz type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation
AT sipowiczkasper type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation
AT kosmalskimarcin type2diabetesmellitusnonalcoholicfattyliverdiseaseandmetabolicrepercussionstheviciouscycleanditsinterplaywithinflammation