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Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation
The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254034/ https://www.ncbi.nlm.nih.gov/pubmed/37298632 http://dx.doi.org/10.3390/ijms24119677 |
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author | Frankowski, Rafał Kobierecki, Mateusz Wittczak, Andrzej Różycka-Kosmalska, Monika Pietras, Tadeusz Sipowicz, Kasper Kosmalski, Marcin |
author_facet | Frankowski, Rafał Kobierecki, Mateusz Wittczak, Andrzej Różycka-Kosmalska, Monika Pietras, Tadeusz Sipowicz, Kasper Kosmalski, Marcin |
author_sort | Frankowski, Rafał |
collection | PubMed |
description | The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our primary focus was on examining the role of chronic inflammation as a potential link in the pathogenesis of these diseases and their interconnections. A comprehensive search of the PubMed database using keywords such as “non-alcoholic fatty liver disease”, “type 2 diabetes mellitus”, “chronic inflammation”, “pathogenesis”, and “progression” yielded 177 relevant papers for our analysis. The findings of our study revealed intricate relationships between the pathogenesis of NAFLD and DM2, emphasizing the crucial role of inflammatory processes. These connections involve various molecular functions, including altered signaling pathways, patterns of gene methylation, the expression of related peptides, and up- and downregulation of several genes. Our study is a foundational platform for future research into the intricate relationship between NAFLD and DM2, allowing for a better understanding of the underlying mechanisms and the potential for introducing new treatment standards. |
format | Online Article Text |
id | pubmed-10254034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102540342023-06-10 Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation Frankowski, Rafał Kobierecki, Mateusz Wittczak, Andrzej Różycka-Kosmalska, Monika Pietras, Tadeusz Sipowicz, Kasper Kosmalski, Marcin Int J Mol Sci Review The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our primary focus was on examining the role of chronic inflammation as a potential link in the pathogenesis of these diseases and their interconnections. A comprehensive search of the PubMed database using keywords such as “non-alcoholic fatty liver disease”, “type 2 diabetes mellitus”, “chronic inflammation”, “pathogenesis”, and “progression” yielded 177 relevant papers for our analysis. The findings of our study revealed intricate relationships between the pathogenesis of NAFLD and DM2, emphasizing the crucial role of inflammatory processes. These connections involve various molecular functions, including altered signaling pathways, patterns of gene methylation, the expression of related peptides, and up- and downregulation of several genes. Our study is a foundational platform for future research into the intricate relationship between NAFLD and DM2, allowing for a better understanding of the underlying mechanisms and the potential for introducing new treatment standards. MDPI 2023-06-02 /pmc/articles/PMC10254034/ /pubmed/37298632 http://dx.doi.org/10.3390/ijms24119677 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frankowski, Rafał Kobierecki, Mateusz Wittczak, Andrzej Różycka-Kosmalska, Monika Pietras, Tadeusz Sipowicz, Kasper Kosmalski, Marcin Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation |
title | Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation |
title_full | Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation |
title_fullStr | Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation |
title_full_unstemmed | Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation |
title_short | Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, and Metabolic Repercussions: The Vicious Cycle and Its Interplay with Inflammation |
title_sort | type 2 diabetes mellitus, non-alcoholic fatty liver disease, and metabolic repercussions: the vicious cycle and its interplay with inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254034/ https://www.ncbi.nlm.nih.gov/pubmed/37298632 http://dx.doi.org/10.3390/ijms24119677 |
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