Cargando…
COVID-19 Therapeutic Potential of Natural Products
Despite the fact that coronavirus disease 2019 (COVID-19) treatment and management are now considerably regulated, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still one of the leading causes of death in 2022. The availability of COVID-19 vaccines, FDA-approved antivirals, and mon...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254072/ https://www.ncbi.nlm.nih.gov/pubmed/37298539 http://dx.doi.org/10.3390/ijms24119589 |
_version_ | 1785056556607340544 |
---|---|
author | Low, Zhaoxuan Lani, Rafidah Tiong, Vunjia Poh, Chitlaa AbuBakar, Sazaly Hassandarvish, Pouya |
author_facet | Low, Zhaoxuan Lani, Rafidah Tiong, Vunjia Poh, Chitlaa AbuBakar, Sazaly Hassandarvish, Pouya |
author_sort | Low, Zhaoxuan |
collection | PubMed |
description | Despite the fact that coronavirus disease 2019 (COVID-19) treatment and management are now considerably regulated, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still one of the leading causes of death in 2022. The availability of COVID-19 vaccines, FDA-approved antivirals, and monoclonal antibodies in low-income countries still poses an issue to be addressed. Natural products, particularly traditional Chinese medicines (TCMs) and medicinal plant extracts (or their active component), have challenged the dominance of drug repurposing and synthetic compound libraries in COVID-19 therapeutics. Their abundant resources and excellent antiviral performance make natural products a relatively cheap and readily available alternative for COVID-19 therapeutics. Here, we deliberately review the anti-SARS-CoV-2 mechanisms of the natural products, their potency (pharmacological profiles), and application strategies for COVID-19 intervention. In light of their advantages, this review is intended to acknowledge the potential of natural products as COVID-19 therapeutic candidates. |
format | Online Article Text |
id | pubmed-10254072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102540722023-06-10 COVID-19 Therapeutic Potential of Natural Products Low, Zhaoxuan Lani, Rafidah Tiong, Vunjia Poh, Chitlaa AbuBakar, Sazaly Hassandarvish, Pouya Int J Mol Sci Review Despite the fact that coronavirus disease 2019 (COVID-19) treatment and management are now considerably regulated, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still one of the leading causes of death in 2022. The availability of COVID-19 vaccines, FDA-approved antivirals, and monoclonal antibodies in low-income countries still poses an issue to be addressed. Natural products, particularly traditional Chinese medicines (TCMs) and medicinal plant extracts (or their active component), have challenged the dominance of drug repurposing and synthetic compound libraries in COVID-19 therapeutics. Their abundant resources and excellent antiviral performance make natural products a relatively cheap and readily available alternative for COVID-19 therapeutics. Here, we deliberately review the anti-SARS-CoV-2 mechanisms of the natural products, their potency (pharmacological profiles), and application strategies for COVID-19 intervention. In light of their advantages, this review is intended to acknowledge the potential of natural products as COVID-19 therapeutic candidates. MDPI 2023-05-31 /pmc/articles/PMC10254072/ /pubmed/37298539 http://dx.doi.org/10.3390/ijms24119589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Low, Zhaoxuan Lani, Rafidah Tiong, Vunjia Poh, Chitlaa AbuBakar, Sazaly Hassandarvish, Pouya COVID-19 Therapeutic Potential of Natural Products |
title | COVID-19 Therapeutic Potential of Natural Products |
title_full | COVID-19 Therapeutic Potential of Natural Products |
title_fullStr | COVID-19 Therapeutic Potential of Natural Products |
title_full_unstemmed | COVID-19 Therapeutic Potential of Natural Products |
title_short | COVID-19 Therapeutic Potential of Natural Products |
title_sort | covid-19 therapeutic potential of natural products |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254072/ https://www.ncbi.nlm.nih.gov/pubmed/37298539 http://dx.doi.org/10.3390/ijms24119589 |
work_keys_str_mv | AT lowzhaoxuan covid19therapeuticpotentialofnaturalproducts AT lanirafidah covid19therapeuticpotentialofnaturalproducts AT tiongvunjia covid19therapeuticpotentialofnaturalproducts AT pohchitlaa covid19therapeuticpotentialofnaturalproducts AT abubakarsazaly covid19therapeuticpotentialofnaturalproducts AT hassandarvishpouya covid19therapeuticpotentialofnaturalproducts |