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Antitumor Activity of s-Triazine Derivatives: A Systematic Review
1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254131/ https://www.ncbi.nlm.nih.gov/pubmed/37298753 http://dx.doi.org/10.3390/molecules28114278 |
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author | Dai, Qiuzi Sun, Qinsheng Ouyang, Xiaorong Liu, Jinyang Jin, Liye Liu, Ahao He, Binsheng Fan, Tingting Jiang, Yuyang |
author_facet | Dai, Qiuzi Sun, Qinsheng Ouyang, Xiaorong Liu, Jinyang Jin, Liye Liu, Ahao He, Binsheng Fan, Tingting Jiang, Yuyang |
author_sort | Dai, Qiuzi |
collection | PubMed |
description | 1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved for refractory ovarian cancer, metastatic breast cancer, and leukemia therapy, respectively, demonstrating that the s-triazine core is a useful scaffold for the discovery of novel anticancer drugs. In this review, we mainly focus on s-triazines targeting topoisomerases, tyrosine kinases, phosphoinositide 3-kinases, NADP+-dependent isocitrate dehydrogenases, and cyclin-dependent kinases in diverse signaling pathways, which have been extensively studied. The medicinal chemistry of s-triazine derivatives as anticancer agents was summarized, including discovery, structure optimization, and biological applications. This review will provide a reference to inspire new and original discoveries. |
format | Online Article Text |
id | pubmed-10254131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102541312023-06-10 Antitumor Activity of s-Triazine Derivatives: A Systematic Review Dai, Qiuzi Sun, Qinsheng Ouyang, Xiaorong Liu, Jinyang Jin, Liye Liu, Ahao He, Binsheng Fan, Tingting Jiang, Yuyang Molecules Review 1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved for refractory ovarian cancer, metastatic breast cancer, and leukemia therapy, respectively, demonstrating that the s-triazine core is a useful scaffold for the discovery of novel anticancer drugs. In this review, we mainly focus on s-triazines targeting topoisomerases, tyrosine kinases, phosphoinositide 3-kinases, NADP+-dependent isocitrate dehydrogenases, and cyclin-dependent kinases in diverse signaling pathways, which have been extensively studied. The medicinal chemistry of s-triazine derivatives as anticancer agents was summarized, including discovery, structure optimization, and biological applications. This review will provide a reference to inspire new and original discoveries. MDPI 2023-05-23 /pmc/articles/PMC10254131/ /pubmed/37298753 http://dx.doi.org/10.3390/molecules28114278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dai, Qiuzi Sun, Qinsheng Ouyang, Xiaorong Liu, Jinyang Jin, Liye Liu, Ahao He, Binsheng Fan, Tingting Jiang, Yuyang Antitumor Activity of s-Triazine Derivatives: A Systematic Review |
title | Antitumor Activity of s-Triazine Derivatives: A Systematic Review |
title_full | Antitumor Activity of s-Triazine Derivatives: A Systematic Review |
title_fullStr | Antitumor Activity of s-Triazine Derivatives: A Systematic Review |
title_full_unstemmed | Antitumor Activity of s-Triazine Derivatives: A Systematic Review |
title_short | Antitumor Activity of s-Triazine Derivatives: A Systematic Review |
title_sort | antitumor activity of s-triazine derivatives: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254131/ https://www.ncbi.nlm.nih.gov/pubmed/37298753 http://dx.doi.org/10.3390/molecules28114278 |
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