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Antitumor Activity of s-Triazine Derivatives: A Systematic Review

1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved...

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Autores principales: Dai, Qiuzi, Sun, Qinsheng, Ouyang, Xiaorong, Liu, Jinyang, Jin, Liye, Liu, Ahao, He, Binsheng, Fan, Tingting, Jiang, Yuyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254131/
https://www.ncbi.nlm.nih.gov/pubmed/37298753
http://dx.doi.org/10.3390/molecules28114278
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author Dai, Qiuzi
Sun, Qinsheng
Ouyang, Xiaorong
Liu, Jinyang
Jin, Liye
Liu, Ahao
He, Binsheng
Fan, Tingting
Jiang, Yuyang
author_facet Dai, Qiuzi
Sun, Qinsheng
Ouyang, Xiaorong
Liu, Jinyang
Jin, Liye
Liu, Ahao
He, Binsheng
Fan, Tingting
Jiang, Yuyang
author_sort Dai, Qiuzi
collection PubMed
description 1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved for refractory ovarian cancer, metastatic breast cancer, and leukemia therapy, respectively, demonstrating that the s-triazine core is a useful scaffold for the discovery of novel anticancer drugs. In this review, we mainly focus on s-triazines targeting topoisomerases, tyrosine kinases, phosphoinositide 3-kinases, NADP+-dependent isocitrate dehydrogenases, and cyclin-dependent kinases in diverse signaling pathways, which have been extensively studied. The medicinal chemistry of s-triazine derivatives as anticancer agents was summarized, including discovery, structure optimization, and biological applications. This review will provide a reference to inspire new and original discoveries.
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spelling pubmed-102541312023-06-10 Antitumor Activity of s-Triazine Derivatives: A Systematic Review Dai, Qiuzi Sun, Qinsheng Ouyang, Xiaorong Liu, Jinyang Jin, Liye Liu, Ahao He, Binsheng Fan, Tingting Jiang, Yuyang Molecules Review 1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved for refractory ovarian cancer, metastatic breast cancer, and leukemia therapy, respectively, demonstrating that the s-triazine core is a useful scaffold for the discovery of novel anticancer drugs. In this review, we mainly focus on s-triazines targeting topoisomerases, tyrosine kinases, phosphoinositide 3-kinases, NADP+-dependent isocitrate dehydrogenases, and cyclin-dependent kinases in diverse signaling pathways, which have been extensively studied. The medicinal chemistry of s-triazine derivatives as anticancer agents was summarized, including discovery, structure optimization, and biological applications. This review will provide a reference to inspire new and original discoveries. MDPI 2023-05-23 /pmc/articles/PMC10254131/ /pubmed/37298753 http://dx.doi.org/10.3390/molecules28114278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dai, Qiuzi
Sun, Qinsheng
Ouyang, Xiaorong
Liu, Jinyang
Jin, Liye
Liu, Ahao
He, Binsheng
Fan, Tingting
Jiang, Yuyang
Antitumor Activity of s-Triazine Derivatives: A Systematic Review
title Antitumor Activity of s-Triazine Derivatives: A Systematic Review
title_full Antitumor Activity of s-Triazine Derivatives: A Systematic Review
title_fullStr Antitumor Activity of s-Triazine Derivatives: A Systematic Review
title_full_unstemmed Antitumor Activity of s-Triazine Derivatives: A Systematic Review
title_short Antitumor Activity of s-Triazine Derivatives: A Systematic Review
title_sort antitumor activity of s-triazine derivatives: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254131/
https://www.ncbi.nlm.nih.gov/pubmed/37298753
http://dx.doi.org/10.3390/molecules28114278
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