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Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging

Olea europaea L. leaf extracts (OLEs) represent highly value-added agro-industrial byproducts, being promising sources of significant antioxidant compounds, such as their main component, oleuropein. In this work, hydrogel films based on low-acyl gellan gum (GG) blended with sodium alginate (NaALG) w...

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Autores principales: Busto, Francesco, Licini, Caterina, Luccarini, Alessia, Damiani, Elisabetta, Mattioli-Belmonte, Monica, Cometa, Stefania, De Giglio, Elvira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254495/
https://www.ncbi.nlm.nih.gov/pubmed/37298828
http://dx.doi.org/10.3390/molecules28114352
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author Busto, Francesco
Licini, Caterina
Luccarini, Alessia
Damiani, Elisabetta
Mattioli-Belmonte, Monica
Cometa, Stefania
De Giglio, Elvira
author_facet Busto, Francesco
Licini, Caterina
Luccarini, Alessia
Damiani, Elisabetta
Mattioli-Belmonte, Monica
Cometa, Stefania
De Giglio, Elvira
author_sort Busto, Francesco
collection PubMed
description Olea europaea L. leaf extracts (OLEs) represent highly value-added agro-industrial byproducts, being promising sources of significant antioxidant compounds, such as their main component, oleuropein. In this work, hydrogel films based on low-acyl gellan gum (GG) blended with sodium alginate (NaALG) were loaded with OLE and crosslinked with tartaric acid (TA). The films’ ability to act as an antioxidant and photoprotectant against UVA-induced photoaging, thanks to their capability to convey oleuropein to the skin, were examined with the aim of a potential application as facial masks. Biological in vitro performances of the proposed materials were tested on normal human dermal fibroblasts (NhDFs), both under normal conditions and after aging-induced UVA treatment. Overall, our results clearly show the intriguing properties of the proposed hydrogels as effective and fully naturally formulated anti-photoaging smart materials for potential use as facial masks.
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spelling pubmed-102544952023-06-10 Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging Busto, Francesco Licini, Caterina Luccarini, Alessia Damiani, Elisabetta Mattioli-Belmonte, Monica Cometa, Stefania De Giglio, Elvira Molecules Article Olea europaea L. leaf extracts (OLEs) represent highly value-added agro-industrial byproducts, being promising sources of significant antioxidant compounds, such as their main component, oleuropein. In this work, hydrogel films based on low-acyl gellan gum (GG) blended with sodium alginate (NaALG) were loaded with OLE and crosslinked with tartaric acid (TA). The films’ ability to act as an antioxidant and photoprotectant against UVA-induced photoaging, thanks to their capability to convey oleuropein to the skin, were examined with the aim of a potential application as facial masks. Biological in vitro performances of the proposed materials were tested on normal human dermal fibroblasts (NhDFs), both under normal conditions and after aging-induced UVA treatment. Overall, our results clearly show the intriguing properties of the proposed hydrogels as effective and fully naturally formulated anti-photoaging smart materials for potential use as facial masks. MDPI 2023-05-25 /pmc/articles/PMC10254495/ /pubmed/37298828 http://dx.doi.org/10.3390/molecules28114352 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Busto, Francesco
Licini, Caterina
Luccarini, Alessia
Damiani, Elisabetta
Mattioli-Belmonte, Monica
Cometa, Stefania
De Giglio, Elvira
Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging
title Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging
title_full Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging
title_fullStr Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging
title_full_unstemmed Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging
title_short Oleuropein-Rich Gellan Gum/Alginate Films as Innovative Treatments against Photo-Induced Skin Aging
title_sort oleuropein-rich gellan gum/alginate films as innovative treatments against photo-induced skin aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254495/
https://www.ncbi.nlm.nih.gov/pubmed/37298828
http://dx.doi.org/10.3390/molecules28114352
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