Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones

In this study, we report a selective approach for synthesizing N-([1,3,5]triazine-2-yl) α-ketoamides and N-([1,3,5]triazine-2-yl) amides from ketones with 2-amino[1,3,5]triazines through oxidation and oxidative C−C bond cleavage reaction, respectively. The transformation proceeds under mild conditio...

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Detalles Bibliográficos
Autores principales: Li, Yue, Zhong, Pengzhen, Zhao, Junna, Pan, Zexi, Zhang, Chen, Cui, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254511/
https://www.ncbi.nlm.nih.gov/pubmed/37298814
http://dx.doi.org/10.3390/molecules28114338
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author Li, Yue
Zhong, Pengzhen
Zhao, Junna
Pan, Zexi
Zhang, Chen
Cui, Dongmei
author_facet Li, Yue
Zhong, Pengzhen
Zhao, Junna
Pan, Zexi
Zhang, Chen
Cui, Dongmei
author_sort Li, Yue
collection PubMed
description In this study, we report a selective approach for synthesizing N-([1,3,5]triazine-2-yl) α-ketoamides and N-([1,3,5]triazine-2-yl) amides from ketones with 2-amino[1,3,5]triazines through oxidation and oxidative C−C bond cleavage reaction, respectively. The transformation proceeds under mild conditions, provides good functional group tolerance and chemoselectivity, and will serve as a valuable tool for the synthesis of bioactive products.
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spelling pubmed-102545112023-06-10 Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones Li, Yue Zhong, Pengzhen Zhao, Junna Pan, Zexi Zhang, Chen Cui, Dongmei Molecules Article In this study, we report a selective approach for synthesizing N-([1,3,5]triazine-2-yl) α-ketoamides and N-([1,3,5]triazine-2-yl) amides from ketones with 2-amino[1,3,5]triazines through oxidation and oxidative C−C bond cleavage reaction, respectively. The transformation proceeds under mild conditions, provides good functional group tolerance and chemoselectivity, and will serve as a valuable tool for the synthesis of bioactive products. MDPI 2023-05-25 /pmc/articles/PMC10254511/ /pubmed/37298814 http://dx.doi.org/10.3390/molecules28114338 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yue
Zhong, Pengzhen
Zhao, Junna
Pan, Zexi
Zhang, Chen
Cui, Dongmei
Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones
title Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones
title_full Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones
title_fullStr Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones
title_full_unstemmed Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones
title_short Selective Synthesis of N-[1,3,5]Triazinyl-α-Ketoamides and N-[1,3,5]Triazinyl-Amides from the Reactions of 2-Amine-[1,3,5]Triazines with Ketones
title_sort selective synthesis of n-[1,3,5]triazinyl-α-ketoamides and n-[1,3,5]triazinyl-amides from the reactions of 2-amine-[1,3,5]triazines with ketones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254511/
https://www.ncbi.nlm.nih.gov/pubmed/37298814
http://dx.doi.org/10.3390/molecules28114338
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