Cargando…

Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines

The aim of this research was to evaluate the essential oil of Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in terms of cytotoxic activity against LNCaP cells, derived from prostate cancer, and HeLa cells, derived from cervical cancer. Antioxidant activities were evaluated...

Descripción completa

Detalles Bibliográficos
Autores principales: Bayala, Bagora, Coulibaly, Laetizia Liz, Djigma, Florencia, Bunay, Julio, Yonli, Albert, Traore, Lassina, Baron, Silvère, Figueredo, Gilles, Simpore, Jacques, Lobaccaro, Jean-Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254514/
https://www.ncbi.nlm.nih.gov/pubmed/37299034
http://dx.doi.org/10.3390/molecules28114561
_version_ 1785056662184263680
author Bayala, Bagora
Coulibaly, Laetizia Liz
Djigma, Florencia
Bunay, Julio
Yonli, Albert
Traore, Lassina
Baron, Silvère
Figueredo, Gilles
Simpore, Jacques
Lobaccaro, Jean-Marc A.
author_facet Bayala, Bagora
Coulibaly, Laetizia Liz
Djigma, Florencia
Bunay, Julio
Yonli, Albert
Traore, Lassina
Baron, Silvère
Figueredo, Gilles
Simpore, Jacques
Lobaccaro, Jean-Marc A.
author_sort Bayala, Bagora
collection PubMed
description The aim of this research was to evaluate the essential oil of Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in terms of cytotoxic activity against LNCaP cells, derived from prostate cancer, and HeLa cells, derived from cervical cancer. Antioxidant activities were evaluated in vitro. Essential oil (EO) was extracted by hydrodistillation and analyzed by GC/FID and GC/MS. Thirty-seven compounds were identified, the major compounds being piperitone (49.9%), δ-2-carene (24.02%), elemol (5.79%) and limonene (4.31%). EO exhibited a poor antioxidant activity, as shown by the inhibition of DPPH radicals (IC(50) = 1730 ± 80 µg/mL) and ABTS(+.) (IC(50) = 2890 ± 26.9 µg/mL). Conversely, EO decreased the proliferation of LNCaP and HeLa cells with respective IC50 values of 135.53 ± 5.27 µg/mL and 146.17 ± 11 µg/mL. EO also prevented LNCaP cell migration and led to the arrest of their cell cycle in the G2/M phase. Altogether, this work points out for the first time that EO of C. schoenanthus from Burkina Faso could be an effective natural anticancer agent.
format Online
Article
Text
id pubmed-10254514
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102545142023-06-10 Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines Bayala, Bagora Coulibaly, Laetizia Liz Djigma, Florencia Bunay, Julio Yonli, Albert Traore, Lassina Baron, Silvère Figueredo, Gilles Simpore, Jacques Lobaccaro, Jean-Marc A. Molecules Article The aim of this research was to evaluate the essential oil of Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in terms of cytotoxic activity against LNCaP cells, derived from prostate cancer, and HeLa cells, derived from cervical cancer. Antioxidant activities were evaluated in vitro. Essential oil (EO) was extracted by hydrodistillation and analyzed by GC/FID and GC/MS. Thirty-seven compounds were identified, the major compounds being piperitone (49.9%), δ-2-carene (24.02%), elemol (5.79%) and limonene (4.31%). EO exhibited a poor antioxidant activity, as shown by the inhibition of DPPH radicals (IC(50) = 1730 ± 80 µg/mL) and ABTS(+.) (IC(50) = 2890 ± 26.9 µg/mL). Conversely, EO decreased the proliferation of LNCaP and HeLa cells with respective IC50 values of 135.53 ± 5.27 µg/mL and 146.17 ± 11 µg/mL. EO also prevented LNCaP cell migration and led to the arrest of their cell cycle in the G2/M phase. Altogether, this work points out for the first time that EO of C. schoenanthus from Burkina Faso could be an effective natural anticancer agent. MDPI 2023-06-05 /pmc/articles/PMC10254514/ /pubmed/37299034 http://dx.doi.org/10.3390/molecules28114561 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bayala, Bagora
Coulibaly, Laetizia Liz
Djigma, Florencia
Bunay, Julio
Yonli, Albert
Traore, Lassina
Baron, Silvère
Figueredo, Gilles
Simpore, Jacques
Lobaccaro, Jean-Marc A.
Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines
title Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines
title_full Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines
title_fullStr Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines
title_full_unstemmed Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines
title_short Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines
title_sort chemical composition of essential oil of cymbopogon schoenanthus (l.) spreng from burkina faso, and effects against prostate and cervical cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254514/
https://www.ncbi.nlm.nih.gov/pubmed/37299034
http://dx.doi.org/10.3390/molecules28114561
work_keys_str_mv AT bayalabagora chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT coulibalylaetizializ chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT djigmaflorencia chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT bunayjulio chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT yonlialbert chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT traorelassina chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT baronsilvere chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT figueredogilles chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT simporejacques chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines
AT lobaccarojeanmarca chemicalcompositionofessentialoilofcymbopogonschoenanthuslsprengfromburkinafasoandeffectsagainstprostateandcervicalcancercelllines