Design and Synthesis of Brefeldin A-Isothiocyanate Derivatives with Selectivity and Their Potential for Cervical Cancer Therapy

Brefeldin A has a wide range of anticancer activity against a variety of tumor cells. Its poor pharmacokinetic properties and significant toxicity seriously hinder its further development. In this manuscript, 25 brefeldin A-isothiocyanate derivatives were designed and synthesized. Most derivatives s...

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Detalles Bibliográficos
Autores principales: Wang, Mingying, Chen, Xiaoyuan, Qu, Ying, Ma, Qingyinglu, Pan, Huaqi, Li, Haonan, Hua, Huiming, Li, Dahong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254530/
https://www.ncbi.nlm.nih.gov/pubmed/37298761
http://dx.doi.org/10.3390/molecules28114284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254530/
https://www.ncbi.nlm.nih.gov/pubmed/37298761
http://dx.doi.org/10.3390/molecules28114284

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