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Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis

INTRODUCTION: Unhealthy alcohol use is associated with a range of adverse outcomes among people with HIV (PWH). Testing the efficacy and promoting the availability of effective interventions to address unhealthy alcohol use among PWH is thus a priority. Alcohol use outcomes in intervention studies a...

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Autores principales: Kane, Jeremy C, Allen, Isabel, Fatch, Robin, Scheffler, Aaron, Emenyonu, Nneka, Puryear, Sarah B, Chirayil, Priya, So-Armah, Kaku, Kahler, Christopher W, Magidson, Jessica F, Conroy, Amy A, Edelman, E Jennifer, Woolf-King, Sarah, Parry, Charles, Kiene, Susan M, Chamie, Gabriel, Adong, Julian, Go, Vivian F, Cook, Robert L, Muyindike, Winnie, Morojele, Neo, Blokhina, Elena, Krupitsky, Evgeny, Fiellin, David A, Hahn, Judith A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254608/
https://www.ncbi.nlm.nih.gov/pubmed/37280036
http://dx.doi.org/10.1136/bmjopen-2022-070713
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author Kane, Jeremy C
Allen, Isabel
Fatch, Robin
Scheffler, Aaron
Emenyonu, Nneka
Puryear, Sarah B
Chirayil, Priya
So-Armah, Kaku
Kahler, Christopher W
Magidson, Jessica F
Conroy, Amy A
Edelman, E Jennifer
Woolf-King, Sarah
Parry, Charles
Kiene, Susan M
Chamie, Gabriel
Adong, Julian
Go, Vivian F
Cook, Robert L
Muyindike, Winnie
Morojele, Neo
Blokhina, Elena
Krupitsky, Evgeny
Fiellin, David A
Hahn, Judith A
author_facet Kane, Jeremy C
Allen, Isabel
Fatch, Robin
Scheffler, Aaron
Emenyonu, Nneka
Puryear, Sarah B
Chirayil, Priya
So-Armah, Kaku
Kahler, Christopher W
Magidson, Jessica F
Conroy, Amy A
Edelman, E Jennifer
Woolf-King, Sarah
Parry, Charles
Kiene, Susan M
Chamie, Gabriel
Adong, Julian
Go, Vivian F
Cook, Robert L
Muyindike, Winnie
Morojele, Neo
Blokhina, Elena
Krupitsky, Evgeny
Fiellin, David A
Hahn, Judith A
author_sort Kane, Jeremy C
collection PubMed
description INTRODUCTION: Unhealthy alcohol use is associated with a range of adverse outcomes among people with HIV (PWH). Testing the efficacy and promoting the availability of effective interventions to address unhealthy alcohol use among PWH is thus a priority. Alcohol use outcomes in intervention studies are often measured by self-report alone, which can lead to spurious results due to information biases (eg, social desirability). Measuring alcohol outcomes objectively through biomarkers, such as phosphatidylethanol (PEth), in addition to self-report has potential to improve the validity of intervention studies. This protocol outlines the methods for a systematic review and individual participant data meta-analysis that will estimate the efficacy of interventions to reduce alcohol use as measured by a combined categorical self-report/PEth variable among PWH and compare these estimates to those generated when alcohol is measured by self-report or PEth alone. METHODS AND ANALYSIS: We will include randomised controlled trials that: (A) tested an alcohol intervention (behavioural and/or pharmacological), (B) enrolled participants 15 years or older with HIV; (C) included both PEth and self-report measurements, (D) completed data collection by 31 August 2023. We will contact principal investigators of eligible studies to inquire about their willingness to contribute data. The primary outcome variable will be a combined self-report/PEth alcohol categorical variable. Secondary outcomes will include PEth alone, self-report alone and HIV viral suppression. We will use a two-step meta-analysis and random effects modelling to estimate pooled treatment effects; I(2) will be calculated to evaluate heterogeneity. Secondary and sensitivity analyses will explore treatment effects in adjusted models and within subgroups. Funnel plots will be used to explore publication bias. ETHICS AND DISSEMINATION: The study will be conducted with deidentified data from completed randomised controlled trials and will be considered exempt from additional ethical approval. Results will be disseminated through peer-reviewed publications and international scientific meetings. PROSPERO REGISTRATION NUMBER: CRD42022373640.
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spelling pubmed-102546082023-06-10 Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis Kane, Jeremy C Allen, Isabel Fatch, Robin Scheffler, Aaron Emenyonu, Nneka Puryear, Sarah B Chirayil, Priya So-Armah, Kaku Kahler, Christopher W Magidson, Jessica F Conroy, Amy A Edelman, E Jennifer Woolf-King, Sarah Parry, Charles Kiene, Susan M Chamie, Gabriel Adong, Julian Go, Vivian F Cook, Robert L Muyindike, Winnie Morojele, Neo Blokhina, Elena Krupitsky, Evgeny Fiellin, David A Hahn, Judith A BMJ Open Addiction INTRODUCTION: Unhealthy alcohol use is associated with a range of adverse outcomes among people with HIV (PWH). Testing the efficacy and promoting the availability of effective interventions to address unhealthy alcohol use among PWH is thus a priority. Alcohol use outcomes in intervention studies are often measured by self-report alone, which can lead to spurious results due to information biases (eg, social desirability). Measuring alcohol outcomes objectively through biomarkers, such as phosphatidylethanol (PEth), in addition to self-report has potential to improve the validity of intervention studies. This protocol outlines the methods for a systematic review and individual participant data meta-analysis that will estimate the efficacy of interventions to reduce alcohol use as measured by a combined categorical self-report/PEth variable among PWH and compare these estimates to those generated when alcohol is measured by self-report or PEth alone. METHODS AND ANALYSIS: We will include randomised controlled trials that: (A) tested an alcohol intervention (behavioural and/or pharmacological), (B) enrolled participants 15 years or older with HIV; (C) included both PEth and self-report measurements, (D) completed data collection by 31 August 2023. We will contact principal investigators of eligible studies to inquire about their willingness to contribute data. The primary outcome variable will be a combined self-report/PEth alcohol categorical variable. Secondary outcomes will include PEth alone, self-report alone and HIV viral suppression. We will use a two-step meta-analysis and random effects modelling to estimate pooled treatment effects; I(2) will be calculated to evaluate heterogeneity. Secondary and sensitivity analyses will explore treatment effects in adjusted models and within subgroups. Funnel plots will be used to explore publication bias. ETHICS AND DISSEMINATION: The study will be conducted with deidentified data from completed randomised controlled trials and will be considered exempt from additional ethical approval. Results will be disseminated through peer-reviewed publications and international scientific meetings. PROSPERO REGISTRATION NUMBER: CRD42022373640. BMJ Publishing Group 2023-06-06 /pmc/articles/PMC10254608/ /pubmed/37280036 http://dx.doi.org/10.1136/bmjopen-2022-070713 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Addiction
Kane, Jeremy C
Allen, Isabel
Fatch, Robin
Scheffler, Aaron
Emenyonu, Nneka
Puryear, Sarah B
Chirayil, Priya
So-Armah, Kaku
Kahler, Christopher W
Magidson, Jessica F
Conroy, Amy A
Edelman, E Jennifer
Woolf-King, Sarah
Parry, Charles
Kiene, Susan M
Chamie, Gabriel
Adong, Julian
Go, Vivian F
Cook, Robert L
Muyindike, Winnie
Morojele, Neo
Blokhina, Elena
Krupitsky, Evgeny
Fiellin, David A
Hahn, Judith A
Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis
title Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis
title_full Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis
title_fullStr Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis
title_full_unstemmed Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis
title_short Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis
title_sort efficacy of alcohol reduction interventions among people with hiv as evaluated by self-report and a phosphatidylethanol (peth) outcome: protocol for a systematic review and individual participant data meta-analysis
topic Addiction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254608/
https://www.ncbi.nlm.nih.gov/pubmed/37280036
http://dx.doi.org/10.1136/bmjopen-2022-070713
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