Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer

Ataxia telangiectasia mutated and Rad3-related (ATR), a vital member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, plays a critical role in the DNA damage response (DDR). Tumor cells with a loss of DDR function or defects in the ataxia telangiectasia mutated (ATM) gene are gener...

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Detalles Bibliográficos
Autores principales: Shao, Jialu, Huang, Lei, Lai, Wenwen, Zou, Yi, Zhu, Qihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254649/
https://www.ncbi.nlm.nih.gov/pubmed/37298997
http://dx.doi.org/10.3390/molecules28114521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254649/
https://www.ncbi.nlm.nih.gov/pubmed/37298997
http://dx.doi.org/10.3390/molecules28114521

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