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XDH and XO Research and Drug Discovery—Personal History
The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of thi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254830/ https://www.ncbi.nlm.nih.gov/pubmed/37298917 http://dx.doi.org/10.3390/molecules28114440 |
| _version_ | 1785056734756208640 |
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| author | Nishino, Takeshi |
| author_facet | Nishino, Takeshi |
| author_sort | Nishino, Takeshi |
| collection | PubMed |
| description | The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of this conversion was elucidated in this study. The physiological and pathological significance of this conversion is presented. Finally, enzyme inhibitors were successfully developed, two of which are used as therapeutic agents for gout. Their wide application potential is also discussed. |
| format | Online Article Text |
| id | pubmed-10254830 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-102548302023-06-10 XDH and XO Research and Drug Discovery—Personal History Nishino, Takeshi Molecules Review The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of this conversion was elucidated in this study. The physiological and pathological significance of this conversion is presented. Finally, enzyme inhibitors were successfully developed, two of which are used as therapeutic agents for gout. Their wide application potential is also discussed. MDPI 2023-05-30 /pmc/articles/PMC10254830/ /pubmed/37298917 http://dx.doi.org/10.3390/molecules28114440 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Nishino, Takeshi XDH and XO Research and Drug Discovery—Personal History |
| title | XDH and XO Research and Drug Discovery—Personal History |
| title_full | XDH and XO Research and Drug Discovery—Personal History |
| title_fullStr | XDH and XO Research and Drug Discovery—Personal History |
| title_full_unstemmed | XDH and XO Research and Drug Discovery—Personal History |
| title_short | XDH and XO Research and Drug Discovery—Personal History |
| title_sort | xdh and xo research and drug discovery—personal history |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254830/ https://www.ncbi.nlm.nih.gov/pubmed/37298917 http://dx.doi.org/10.3390/molecules28114440 |
| work_keys_str_mv | AT nishinotakeshi xdhandxoresearchanddrugdiscoverypersonalhistory |