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Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
Haemangioblastoma is a morphologically distinctive tumour with uncertain histogenesis, typically occurring in the cerebellum, brain stem or spinal cord and less commonly in extraneural locations. Here, we present a case of haemangioblastoma occurring in the tongue, which is the first reported case i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254896/ https://www.ncbi.nlm.nih.gov/pubmed/37258051 http://dx.doi.org/10.1136/bcr-2023-255581 |
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author | Chen, Yacun Chen, Jie Jiang, Ye Lin, Xiang |
author_facet | Chen, Yacun Chen, Jie Jiang, Ye Lin, Xiang |
author_sort | Chen, Yacun |
collection | PubMed |
description | Haemangioblastoma is a morphologically distinctive tumour with uncertain histogenesis, typically occurring in the cerebellum, brain stem or spinal cord and less commonly in extraneural locations. Here, we present a case of haemangioblastoma occurring in the tongue, which is the first reported case in terms of the pathogenic site. The tumour was morphologically indistinguishable from central nervous system haemangioblastoma, that is, neoplastic stromal cells with cytoplasmic vacuolisation and abundant small vessels. Immunohistochemical studies revealed that the tumour cells were positive for S100, NSE, CD56, Syn, EMA, vimentin and α-inhibin, while negative for CK, SMA, factor Ⅷ, D2-40 and GFAP. Immunostainings for CD34 and CD31 outlined the rich and delicate vascular channels. Ki-67 expression was presented in approximately 3% of tumour cells. Primary haemangioblastoma has not been previously described at this site, and this case emphasises the need to consider haemangioblastoma in the differential diagnoses of neoplasms occurring in the tongue. |
format | Online Article Text |
id | pubmed-10254896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-102548962023-06-10 Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue Chen, Yacun Chen, Jie Jiang, Ye Lin, Xiang BMJ Case Rep Case Reports: Rare disease Haemangioblastoma is a morphologically distinctive tumour with uncertain histogenesis, typically occurring in the cerebellum, brain stem or spinal cord and less commonly in extraneural locations. Here, we present a case of haemangioblastoma occurring in the tongue, which is the first reported case in terms of the pathogenic site. The tumour was morphologically indistinguishable from central nervous system haemangioblastoma, that is, neoplastic stromal cells with cytoplasmic vacuolisation and abundant small vessels. Immunohistochemical studies revealed that the tumour cells were positive for S100, NSE, CD56, Syn, EMA, vimentin and α-inhibin, while negative for CK, SMA, factor Ⅷ, D2-40 and GFAP. Immunostainings for CD34 and CD31 outlined the rich and delicate vascular channels. Ki-67 expression was presented in approximately 3% of tumour cells. Primary haemangioblastoma has not been previously described at this site, and this case emphasises the need to consider haemangioblastoma in the differential diagnoses of neoplasms occurring in the tongue. BMJ Publishing Group 2023-05-31 /pmc/articles/PMC10254896/ /pubmed/37258051 http://dx.doi.org/10.1136/bcr-2023-255581 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Case Reports: Rare disease Chen, Yacun Chen, Jie Jiang, Ye Lin, Xiang Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
title | Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
title_full | Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
title_fullStr | Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
title_full_unstemmed | Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
title_short | Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
title_sort | clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue |
topic | Case Reports: Rare disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254896/ https://www.ncbi.nlm.nih.gov/pubmed/37258051 http://dx.doi.org/10.1136/bcr-2023-255581 |
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