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Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue

Haemangioblastoma is a morphologically distinctive tumour with uncertain histogenesis, typically occurring in the cerebellum, brain stem or spinal cord and less commonly in extraneural locations. Here, we present a case of haemangioblastoma occurring in the tongue, which is the first reported case i...

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Autores principales: Chen, Yacun, Chen, Jie, Jiang, Ye, Lin, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254896/
https://www.ncbi.nlm.nih.gov/pubmed/37258051
http://dx.doi.org/10.1136/bcr-2023-255581
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author Chen, Yacun
Chen, Jie
Jiang, Ye
Lin, Xiang
author_facet Chen, Yacun
Chen, Jie
Jiang, Ye
Lin, Xiang
author_sort Chen, Yacun
collection PubMed
description Haemangioblastoma is a morphologically distinctive tumour with uncertain histogenesis, typically occurring in the cerebellum, brain stem or spinal cord and less commonly in extraneural locations. Here, we present a case of haemangioblastoma occurring in the tongue, which is the first reported case in terms of the pathogenic site. The tumour was morphologically indistinguishable from central nervous system haemangioblastoma, that is, neoplastic stromal cells with cytoplasmic vacuolisation and abundant small vessels. Immunohistochemical studies revealed that the tumour cells were positive for S100, NSE, CD56, Syn, EMA, vimentin and α-inhibin, while negative for CK, SMA, factor Ⅷ, D2-40 and GFAP. Immunostainings for CD34 and CD31 outlined the rich and delicate vascular channels. Ki-67 expression was presented in approximately 3% of tumour cells. Primary haemangioblastoma has not been previously described at this site, and this case emphasises the need to consider haemangioblastoma in the differential diagnoses of neoplasms occurring in the tongue.
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spelling pubmed-102548962023-06-10 Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue Chen, Yacun Chen, Jie Jiang, Ye Lin, Xiang BMJ Case Rep Case Reports: Rare disease Haemangioblastoma is a morphologically distinctive tumour with uncertain histogenesis, typically occurring in the cerebellum, brain stem or spinal cord and less commonly in extraneural locations. Here, we present a case of haemangioblastoma occurring in the tongue, which is the first reported case in terms of the pathogenic site. The tumour was morphologically indistinguishable from central nervous system haemangioblastoma, that is, neoplastic stromal cells with cytoplasmic vacuolisation and abundant small vessels. Immunohistochemical studies revealed that the tumour cells were positive for S100, NSE, CD56, Syn, EMA, vimentin and α-inhibin, while negative for CK, SMA, factor Ⅷ, D2-40 and GFAP. Immunostainings for CD34 and CD31 outlined the rich and delicate vascular channels. Ki-67 expression was presented in approximately 3% of tumour cells. Primary haemangioblastoma has not been previously described at this site, and this case emphasises the need to consider haemangioblastoma in the differential diagnoses of neoplasms occurring in the tongue. BMJ Publishing Group 2023-05-31 /pmc/articles/PMC10254896/ /pubmed/37258051 http://dx.doi.org/10.1136/bcr-2023-255581 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Rare disease
Chen, Yacun
Chen, Jie
Jiang, Ye
Lin, Xiang
Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
title Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
title_full Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
title_fullStr Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
title_full_unstemmed Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
title_short Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
title_sort clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue
topic Case Reports: Rare disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254896/
https://www.ncbi.nlm.nih.gov/pubmed/37258051
http://dx.doi.org/10.1136/bcr-2023-255581
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