Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity

Behçet’s disease commonly affects 20–40-year-old men and shows ophthalmo-dermatological manifestations. Here, we report a man in his 70s with acute onset of dysarthria, dysphagia and hemiplegia showing brainstem and subcortical lesions, which responded to steroid and colchicine therapy. He had a his...

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Autores principales: Shiraishi, Wataru, Tsujimoto, Yoshitaka, Matsuyoshi, Ayano, Hashimoto, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Case Reports: Unusual association of diseases/symptoms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254956/
https://www.ncbi.nlm.nih.gov/pubmed/37263675
http://dx.doi.org/10.1136/bcr-2022-252033
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author Shiraishi, Wataru
Tsujimoto, Yoshitaka
Matsuyoshi, Ayano
Hashimoto, Tetsuya
author_facet Shiraishi, Wataru
Tsujimoto, Yoshitaka
Matsuyoshi, Ayano
Hashimoto, Tetsuya
author_sort Shiraishi, Wataru
collection PubMed
description Behçet’s disease commonly affects 20–40-year-old men and shows ophthalmo-dermatological manifestations. Here, we report a man in his 70s with acute onset of dysarthria, dysphagia and hemiplegia showing brainstem and subcortical lesions, which responded to steroid and colchicine therapy. He had a history of uveitis and was homozygous for the human leucocyte antigen-B51 allele, and we clinically diagnosed him with acute neuro-Behçet’s disease. Old-age onset neuro-Behçet’s disease is uncommon, and as far as we know, this is the oldest case of the first attack of neuro-Behçet’s disease. Clinicians should consider Behçet’s disease even for elderly patients.
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spelling pubmed-102549562023-06-10 Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity Shiraishi, Wataru Tsujimoto, Yoshitaka Matsuyoshi, Ayano Hashimoto, Tetsuya BMJ Case Rep Case Reports: Unusual association of diseases/symptoms Behçet’s disease commonly affects 20–40-year-old men and shows ophthalmo-dermatological manifestations. Here, we report a man in his 70s with acute onset of dysarthria, dysphagia and hemiplegia showing brainstem and subcortical lesions, which responded to steroid and colchicine therapy. He had a history of uveitis and was homozygous for the human leucocyte antigen-B51 allele, and we clinically diagnosed him with acute neuro-Behçet’s disease. Old-age onset neuro-Behçet’s disease is uncommon, and as far as we know, this is the oldest case of the first attack of neuro-Behçet’s disease. Clinicians should consider Behçet’s disease even for elderly patients. BMJ Publishing Group 2023-06-01 /pmc/articles/PMC10254956/ /pubmed/37263675 http://dx.doi.org/10.1136/bcr-2022-252033 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Unusual association of diseases/symptoms
Shiraishi, Wataru
Tsujimoto, Yoshitaka
Matsuyoshi, Ayano
Hashimoto, Tetsuya
Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity
title Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity
title_full Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity
title_fullStr Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity
title_full_unstemmed Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity
title_short Case of elderly onset possible neuro-Behçet’s disease with HLA-B51 homozygosity
title_sort case of elderly onset possible neuro-behçet’s disease with hla-b51 homozygosity
topic Case Reports: Unusual association of diseases/symptoms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254956/
https://www.ncbi.nlm.nih.gov/pubmed/37263675
http://dx.doi.org/10.1136/bcr-2022-252033
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