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Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial

Background: There is a very high prevalence of subclinical vitamin K deficiency in patients requiring hemodialysis (HD), and this problem is associated with vascular calcification and arterial stiffness. Vitamin K2 (MK-7) supplementation can improve vitamin K status in HD patients. However, the bene...

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Autores principales: Naiyarakseree, Nuanjanthip, Phannajit, Jeerath, Naiyarakseree, Wichai, Mahatanan, Nanta, Asavapujanamanee, Pagaporn, Lekhyananda, Sookruetai, Vanichakarn, Supat, Avihingsanon, Yingyos, Praditpornsilpa, Kearkiat, Eiam-Ong, Somchai, Susantitaphong, Paweena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255064/
https://www.ncbi.nlm.nih.gov/pubmed/37299386
http://dx.doi.org/10.3390/nu15112422
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author Naiyarakseree, Nuanjanthip
Phannajit, Jeerath
Naiyarakseree, Wichai
Mahatanan, Nanta
Asavapujanamanee, Pagaporn
Lekhyananda, Sookruetai
Vanichakarn, Supat
Avihingsanon, Yingyos
Praditpornsilpa, Kearkiat
Eiam-Ong, Somchai
Susantitaphong, Paweena
author_facet Naiyarakseree, Nuanjanthip
Phannajit, Jeerath
Naiyarakseree, Wichai
Mahatanan, Nanta
Asavapujanamanee, Pagaporn
Lekhyananda, Sookruetai
Vanichakarn, Supat
Avihingsanon, Yingyos
Praditpornsilpa, Kearkiat
Eiam-Ong, Somchai
Susantitaphong, Paweena
author_sort Naiyarakseree, Nuanjanthip
collection PubMed
description Background: There is a very high prevalence of subclinical vitamin K deficiency in patients requiring hemodialysis (HD), and this problem is associated with vascular calcification and arterial stiffness. Vitamin K2 (MK-7) supplementation can improve vitamin K status in HD patients. However, the benefits of vitamin K supplementation on arterial stiffness have still not been established. The present study was conducted to evaluate the efficacy of menaquinone-7 (MK-7) supplementation on arterial stiffness in chronic HD patients. Methods: This open-label multicenter randomized clinical trial was conducted in 96 HD patients who had arterial stiffness, defined by high carotid femoral pulse wave velocity (cfPWV ≥ 10 m/s). The patients were randomly assigned to receive oral MK-7 (375 mcg once daily) for 24 weeks (n = 50) or standard care (control group; n = 46). The change in cfPWV was the primary outcome. Results: Baseline parameters were comparable between the two groups. There was no significant difference in the change in cPWV at 24 weeks between the MK-7 group and standard care [−6.0% (−20.2, 2.3) vs. −6.8% (−19.0, 7.3), p = 0.24]. However, we found that MK-7 significantly decreased cPWV in patients with diabetes [−10.0% (−15.9, −0.8) vs. 3.8% (−5.8, 11.6), p = 0.008]. In addition, the MK-7 group had a lower rate of arterial stiffness progression, compared to controls (30.2% vs. 39.5%, p = 0.37), especially in diabetes patients (21.4% vs. 72.7%, p = 0.01). No serious adverse events were observed during the 24 weeks. Conclusion: Vitamin K supplements provided a beneficial impact in lowering the rate of arterial stiffness progression in chronic hemodialysis patients with diabetes. Possible benefits on cardiovascular outcomes require further investigation.
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spelling pubmed-102550642023-06-10 Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial Naiyarakseree, Nuanjanthip Phannajit, Jeerath Naiyarakseree, Wichai Mahatanan, Nanta Asavapujanamanee, Pagaporn Lekhyananda, Sookruetai Vanichakarn, Supat Avihingsanon, Yingyos Praditpornsilpa, Kearkiat Eiam-Ong, Somchai Susantitaphong, Paweena Nutrients Article Background: There is a very high prevalence of subclinical vitamin K deficiency in patients requiring hemodialysis (HD), and this problem is associated with vascular calcification and arterial stiffness. Vitamin K2 (MK-7) supplementation can improve vitamin K status in HD patients. However, the benefits of vitamin K supplementation on arterial stiffness have still not been established. The present study was conducted to evaluate the efficacy of menaquinone-7 (MK-7) supplementation on arterial stiffness in chronic HD patients. Methods: This open-label multicenter randomized clinical trial was conducted in 96 HD patients who had arterial stiffness, defined by high carotid femoral pulse wave velocity (cfPWV ≥ 10 m/s). The patients were randomly assigned to receive oral MK-7 (375 mcg once daily) for 24 weeks (n = 50) or standard care (control group; n = 46). The change in cfPWV was the primary outcome. Results: Baseline parameters were comparable between the two groups. There was no significant difference in the change in cPWV at 24 weeks between the MK-7 group and standard care [−6.0% (−20.2, 2.3) vs. −6.8% (−19.0, 7.3), p = 0.24]. However, we found that MK-7 significantly decreased cPWV in patients with diabetes [−10.0% (−15.9, −0.8) vs. 3.8% (−5.8, 11.6), p = 0.008]. In addition, the MK-7 group had a lower rate of arterial stiffness progression, compared to controls (30.2% vs. 39.5%, p = 0.37), especially in diabetes patients (21.4% vs. 72.7%, p = 0.01). No serious adverse events were observed during the 24 weeks. Conclusion: Vitamin K supplements provided a beneficial impact in lowering the rate of arterial stiffness progression in chronic hemodialysis patients with diabetes. Possible benefits on cardiovascular outcomes require further investigation. MDPI 2023-05-23 /pmc/articles/PMC10255064/ /pubmed/37299386 http://dx.doi.org/10.3390/nu15112422 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naiyarakseree, Nuanjanthip
Phannajit, Jeerath
Naiyarakseree, Wichai
Mahatanan, Nanta
Asavapujanamanee, Pagaporn
Lekhyananda, Sookruetai
Vanichakarn, Supat
Avihingsanon, Yingyos
Praditpornsilpa, Kearkiat
Eiam-Ong, Somchai
Susantitaphong, Paweena
Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial
title Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial
title_full Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial
title_fullStr Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial
title_full_unstemmed Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial
title_short Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial
title_sort effect of menaquinone-7 supplementation on arterial stiffness in chronic hemodialysis patients: a multicenter randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255064/
https://www.ncbi.nlm.nih.gov/pubmed/37299386
http://dx.doi.org/10.3390/nu15112422
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