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Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst

It is well known that viruses cannot replicate on their own but only inside the cells of target tissues in the organism, resulting in the destruction of the cells or, in some cases, their transformation into cancer cells. While viruses have relatively low resistance in the environment, their ability...

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Autores principales: Porcu, Stefania, Maloccu, Stefania, Corona, Angela, Hazra, Moulika, David, Tullia Carla, Chiriu, Daniele, Carbonaro, Carlo Maria, Tramontano, Enzo, Ricci, Pier Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255258/
https://www.ncbi.nlm.nih.gov/pubmed/37299335
http://dx.doi.org/10.3390/polym15112536
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author Porcu, Stefania
Maloccu, Stefania
Corona, Angela
Hazra, Moulika
David, Tullia Carla
Chiriu, Daniele
Carbonaro, Carlo Maria
Tramontano, Enzo
Ricci, Pier Carlo
author_facet Porcu, Stefania
Maloccu, Stefania
Corona, Angela
Hazra, Moulika
David, Tullia Carla
Chiriu, Daniele
Carbonaro, Carlo Maria
Tramontano, Enzo
Ricci, Pier Carlo
author_sort Porcu, Stefania
collection PubMed
description It is well known that viruses cannot replicate on their own but only inside the cells of target tissues in the organism, resulting in the destruction of the cells or, in some cases, their transformation into cancer cells. While viruses have relatively low resistance in the environment, their ability to survive longer is based on environmental conditions and the type of substrate on which they are deposited. Recently, the potential for safe and efficient viral inactivation by photocatalysis has garnered increasing attention. In this study, the Phenyl carbon nitride/TiO(2) heterojunction system, a hybrid organic–inorganic photocatalyst, was utilized to investigate its effectiveness in degrading the flu virus (H1N1). The system was activated by a white-LED lamp, and the process was tested on MDCK cells infected with the flu virus. The results of the study demonstrate the hybrid photocatalyst’s ability to cause the virus to degrade, highlighting its effectiveness for safe and efficient viral inactivation in the visible light range. Additionally, the study underscores the advantages of using this hybrid photocatalyst over traditional inorganic photocatalysts, which typically only work in the ultraviolet range.
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spelling pubmed-102552582023-06-10 Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst Porcu, Stefania Maloccu, Stefania Corona, Angela Hazra, Moulika David, Tullia Carla Chiriu, Daniele Carbonaro, Carlo Maria Tramontano, Enzo Ricci, Pier Carlo Polymers (Basel) Article It is well known that viruses cannot replicate on their own but only inside the cells of target tissues in the organism, resulting in the destruction of the cells or, in some cases, their transformation into cancer cells. While viruses have relatively low resistance in the environment, their ability to survive longer is based on environmental conditions and the type of substrate on which they are deposited. Recently, the potential for safe and efficient viral inactivation by photocatalysis has garnered increasing attention. In this study, the Phenyl carbon nitride/TiO(2) heterojunction system, a hybrid organic–inorganic photocatalyst, was utilized to investigate its effectiveness in degrading the flu virus (H1N1). The system was activated by a white-LED lamp, and the process was tested on MDCK cells infected with the flu virus. The results of the study demonstrate the hybrid photocatalyst’s ability to cause the virus to degrade, highlighting its effectiveness for safe and efficient viral inactivation in the visible light range. Additionally, the study underscores the advantages of using this hybrid photocatalyst over traditional inorganic photocatalysts, which typically only work in the ultraviolet range. MDPI 2023-05-31 /pmc/articles/PMC10255258/ /pubmed/37299335 http://dx.doi.org/10.3390/polym15112536 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Porcu, Stefania
Maloccu, Stefania
Corona, Angela
Hazra, Moulika
David, Tullia Carla
Chiriu, Daniele
Carbonaro, Carlo Maria
Tramontano, Enzo
Ricci, Pier Carlo
Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
title Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
title_full Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
title_fullStr Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
title_full_unstemmed Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
title_short Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
title_sort visible light-mediated inactivation of h1n1 virus usingpolymer-based heterojunction photocatalyst
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255258/
https://www.ncbi.nlm.nih.gov/pubmed/37299335
http://dx.doi.org/10.3390/polym15112536
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