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Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature

Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been...

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Autores principales: Capelli, Irene, Lerario, Sarah, Aiello, Valeria, Provenzano, Michele, Di Costanzo, Roberta, Squadrani, Andrea, Vella, Anna, Vicennati, Valentina, Poli, Carolina, La Manna, Gaetano, Baraldi, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255338/
https://www.ncbi.nlm.nih.gov/pubmed/37299584
http://dx.doi.org/10.3390/nu15112621
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author Capelli, Irene
Lerario, Sarah
Aiello, Valeria
Provenzano, Michele
Di Costanzo, Roberta
Squadrani, Andrea
Vella, Anna
Vicennati, Valentina
Poli, Carolina
La Manna, Gaetano
Baraldi, Olga
author_facet Capelli, Irene
Lerario, Sarah
Aiello, Valeria
Provenzano, Michele
Di Costanzo, Roberta
Squadrani, Andrea
Vella, Anna
Vicennati, Valentina
Poli, Carolina
La Manna, Gaetano
Baraldi, Olga
author_sort Capelli, Irene
collection PubMed
description Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out.
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spelling pubmed-102553382023-06-10 Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature Capelli, Irene Lerario, Sarah Aiello, Valeria Provenzano, Michele Di Costanzo, Roberta Squadrani, Andrea Vella, Anna Vicennati, Valentina Poli, Carolina La Manna, Gaetano Baraldi, Olga Nutrients Review Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out. MDPI 2023-06-03 /pmc/articles/PMC10255338/ /pubmed/37299584 http://dx.doi.org/10.3390/nu15112621 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Capelli, Irene
Lerario, Sarah
Aiello, Valeria
Provenzano, Michele
Di Costanzo, Roberta
Squadrani, Andrea
Vella, Anna
Vicennati, Valentina
Poli, Carolina
La Manna, Gaetano
Baraldi, Olga
Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
title Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
title_full Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
title_fullStr Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
title_full_unstemmed Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
title_short Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
title_sort diet and physical activity in adult dominant polycystic kidney disease: a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255338/
https://www.ncbi.nlm.nih.gov/pubmed/37299584
http://dx.doi.org/10.3390/nu15112621
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