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Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature
Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255338/ https://www.ncbi.nlm.nih.gov/pubmed/37299584 http://dx.doi.org/10.3390/nu15112621 |
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author | Capelli, Irene Lerario, Sarah Aiello, Valeria Provenzano, Michele Di Costanzo, Roberta Squadrani, Andrea Vella, Anna Vicennati, Valentina Poli, Carolina La Manna, Gaetano Baraldi, Olga |
author_facet | Capelli, Irene Lerario, Sarah Aiello, Valeria Provenzano, Michele Di Costanzo, Roberta Squadrani, Andrea Vella, Anna Vicennati, Valentina Poli, Carolina La Manna, Gaetano Baraldi, Olga |
author_sort | Capelli, Irene |
collection | PubMed |
description | Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out. |
format | Online Article Text |
id | pubmed-10255338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102553382023-06-10 Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature Capelli, Irene Lerario, Sarah Aiello, Valeria Provenzano, Michele Di Costanzo, Roberta Squadrani, Andrea Vella, Anna Vicennati, Valentina Poli, Carolina La Manna, Gaetano Baraldi, Olga Nutrients Review Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effect on patients’ daily life. Recently, the literature has been enriched with new works that analyze possible non-pharmacological therapeutic strategies to slow cysts’ enlargement and chronic kidney disease progression. Among them, dietary schemes reducing carbohydrate intake and inducing ketoses have been demonstrated to have efficacy in several pre-clinical and clinical studies. A ketogenic diet, calorie restriction, intermittent fasting, and time-restricted feeding can reduce aerobic glycolysis and inhibit the mTOR pathway, producing a reduction in cyst cell proliferation, a reduction in kidney volume, and helping to preserve kidney function. ADPKD’s burden of disease has an impact on patients’ quality of life, and the possibility to play sports or carry out physical exercise can help people in everyday life. The multisystemic character of the disease, especially cardiovascular involvement, needs to be carefully evaluated to establish the quality and quantity of physical activity that patients can safely carry out. MDPI 2023-06-03 /pmc/articles/PMC10255338/ /pubmed/37299584 http://dx.doi.org/10.3390/nu15112621 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Capelli, Irene Lerario, Sarah Aiello, Valeria Provenzano, Michele Di Costanzo, Roberta Squadrani, Andrea Vella, Anna Vicennati, Valentina Poli, Carolina La Manna, Gaetano Baraldi, Olga Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature |
title | Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature |
title_full | Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature |
title_fullStr | Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature |
title_full_unstemmed | Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature |
title_short | Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature |
title_sort | diet and physical activity in adult dominant polycystic kidney disease: a review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255338/ https://www.ncbi.nlm.nih.gov/pubmed/37299584 http://dx.doi.org/10.3390/nu15112621 |
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