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The Potential of Natural Oils to Improve Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD), the exact cause of which is still unknown. Numerous studies have confirmed that diet is one of the major environmental factors associated with IBD, as it can...

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Autores principales: Zhou, Yaxi, Wang, Diandian, Duan, Hao, Zhou, Shiqi, Guo, Jinhong, Yan, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255559/
https://www.ncbi.nlm.nih.gov/pubmed/37299569
http://dx.doi.org/10.3390/nu15112606
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author Zhou, Yaxi
Wang, Diandian
Duan, Hao
Zhou, Shiqi
Guo, Jinhong
Yan, Wenjie
author_facet Zhou, Yaxi
Wang, Diandian
Duan, Hao
Zhou, Shiqi
Guo, Jinhong
Yan, Wenjie
author_sort Zhou, Yaxi
collection PubMed
description Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD), the exact cause of which is still unknown. Numerous studies have confirmed that diet is one of the major environmental factors associated with IBD, as it can regulate the gut microbiota and reduce inflammation and oxidative stress. Since the consumption of oil is essential in the diet, improving IBD through oil has potential. In this article, we first briefly reviewed the current treatment methods for IBD and introduce the role of natural oils in improving inflammatory diseases. We then focused on the recent discovery of the role of natural oils in the prevention and treatment of IBD and summarized their main mechanisms of action. The results showed that the anti-inflammatory activity of oils derived from different plants and animals has been validated in various experimental animal models. These oils are capable of improving the intestinal homeostasis in IBD animal models through multiple mechanisms, including modulation of the gut microbiota, protection of the intestinal barrier, reduction in colonic inflammation, improvement in oxidative stress levels in the intestine, and regulation of immune homeostasis. Therefore, dietary or topical use of natural oils may have potential therapeutic effects on IBD. However, currently, only a few clinical trials support the aforementioned conclusions. This review emphasized the positive effects of natural oils on IBD and encouraged more clinical trials to provide more reliable evidence on the improvement of human IBD by natural oils as functional substances.
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spelling pubmed-102555592023-06-10 The Potential of Natural Oils to Improve Inflammatory Bowel Disease Zhou, Yaxi Wang, Diandian Duan, Hao Zhou, Shiqi Guo, Jinhong Yan, Wenjie Nutrients Review Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD), the exact cause of which is still unknown. Numerous studies have confirmed that diet is one of the major environmental factors associated with IBD, as it can regulate the gut microbiota and reduce inflammation and oxidative stress. Since the consumption of oil is essential in the diet, improving IBD through oil has potential. In this article, we first briefly reviewed the current treatment methods for IBD and introduce the role of natural oils in improving inflammatory diseases. We then focused on the recent discovery of the role of natural oils in the prevention and treatment of IBD and summarized their main mechanisms of action. The results showed that the anti-inflammatory activity of oils derived from different plants and animals has been validated in various experimental animal models. These oils are capable of improving the intestinal homeostasis in IBD animal models through multiple mechanisms, including modulation of the gut microbiota, protection of the intestinal barrier, reduction in colonic inflammation, improvement in oxidative stress levels in the intestine, and regulation of immune homeostasis. Therefore, dietary or topical use of natural oils may have potential therapeutic effects on IBD. However, currently, only a few clinical trials support the aforementioned conclusions. This review emphasized the positive effects of natural oils on IBD and encouraged more clinical trials to provide more reliable evidence on the improvement of human IBD by natural oils as functional substances. MDPI 2023-06-01 /pmc/articles/PMC10255559/ /pubmed/37299569 http://dx.doi.org/10.3390/nu15112606 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhou, Yaxi
Wang, Diandian
Duan, Hao
Zhou, Shiqi
Guo, Jinhong
Yan, Wenjie
The Potential of Natural Oils to Improve Inflammatory Bowel Disease
title The Potential of Natural Oils to Improve Inflammatory Bowel Disease
title_full The Potential of Natural Oils to Improve Inflammatory Bowel Disease
title_fullStr The Potential of Natural Oils to Improve Inflammatory Bowel Disease
title_full_unstemmed The Potential of Natural Oils to Improve Inflammatory Bowel Disease
title_short The Potential of Natural Oils to Improve Inflammatory Bowel Disease
title_sort potential of natural oils to improve inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255559/
https://www.ncbi.nlm.nih.gov/pubmed/37299569
http://dx.doi.org/10.3390/nu15112606
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