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D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation

INTRODUCTION: Koumine (KME) is the most abundant active ingredient separated from Gelsemium elegans Benth and exhibits a significant therapeutic effect on rheumatoid arthritis (RA). It is a lipophilic compound with poor aqueous solubility, and there is an urgent need to develop novel dosage forms of...

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Detalles Bibliográficos
Autores principales:	Hu, Qing, Fu, Xiao-Ling, Dong, Yi-Yan, Ma, Ju, Hua, Jian, Li, Jia-Ting, Liu, Kai-Xin, Yang, Jian, Yu, Chang-Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255651/ https://www.ncbi.nlm.nih.gov/pubmed/37304972 http://dx.doi.org/10.2147/IJN.S406641

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