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Hematopoietic Stem Cell: Regulation and Nutritional Intervention

Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarize...

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Detalles Bibliográficos
Autores principales: Sun, Siyuan, Han, Yingxue, Lei, Yumei, Yu, Yifei, Dong, Yanbin, Chen, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255666/
https://www.ncbi.nlm.nih.gov/pubmed/37299568
http://dx.doi.org/10.3390/nu15112605
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author Sun, Siyuan
Han, Yingxue
Lei, Yumei
Yu, Yifei
Dong, Yanbin
Chen, Juan
author_facet Sun, Siyuan
Han, Yingxue
Lei, Yumei
Yu, Yifei
Dong, Yanbin
Chen, Juan
author_sort Sun, Siyuan
collection PubMed
description Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarizes the intrinsic factors (i.e., RNA-binding protein, modulators in epigenetics and enhancer–promotor-mediated transcription) that are reported to play a pivotal role in the function of HSCs, therapies for bone marrow transplantation, and the relationship between HSCs and autoimmune diseases. It also demonstrates the current studies on the effects of high-fat diets and nutrients (i.e., vitamins, amino acids, probiotics and prebiotics) on regulating HSCs, providing a deep insight into the future HSC research.
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spelling pubmed-102556662023-06-10 Hematopoietic Stem Cell: Regulation and Nutritional Intervention Sun, Siyuan Han, Yingxue Lei, Yumei Yu, Yifei Dong, Yanbin Chen, Juan Nutrients Review Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarizes the intrinsic factors (i.e., RNA-binding protein, modulators in epigenetics and enhancer–promotor-mediated transcription) that are reported to play a pivotal role in the function of HSCs, therapies for bone marrow transplantation, and the relationship between HSCs and autoimmune diseases. It also demonstrates the current studies on the effects of high-fat diets and nutrients (i.e., vitamins, amino acids, probiotics and prebiotics) on regulating HSCs, providing a deep insight into the future HSC research. MDPI 2023-06-01 /pmc/articles/PMC10255666/ /pubmed/37299568 http://dx.doi.org/10.3390/nu15112605 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Siyuan
Han, Yingxue
Lei, Yumei
Yu, Yifei
Dong, Yanbin
Chen, Juan
Hematopoietic Stem Cell: Regulation and Nutritional Intervention
title Hematopoietic Stem Cell: Regulation and Nutritional Intervention
title_full Hematopoietic Stem Cell: Regulation and Nutritional Intervention
title_fullStr Hematopoietic Stem Cell: Regulation and Nutritional Intervention
title_full_unstemmed Hematopoietic Stem Cell: Regulation and Nutritional Intervention
title_short Hematopoietic Stem Cell: Regulation and Nutritional Intervention
title_sort hematopoietic stem cell: regulation and nutritional intervention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255666/
https://www.ncbi.nlm.nih.gov/pubmed/37299568
http://dx.doi.org/10.3390/nu15112605
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