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Hematopoietic Stem Cell: Regulation and Nutritional Intervention
Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarize...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255666/ https://www.ncbi.nlm.nih.gov/pubmed/37299568 http://dx.doi.org/10.3390/nu15112605 |
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author | Sun, Siyuan Han, Yingxue Lei, Yumei Yu, Yifei Dong, Yanbin Chen, Juan |
author_facet | Sun, Siyuan Han, Yingxue Lei, Yumei Yu, Yifei Dong, Yanbin Chen, Juan |
author_sort | Sun, Siyuan |
collection | PubMed |
description | Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarizes the intrinsic factors (i.e., RNA-binding protein, modulators in epigenetics and enhancer–promotor-mediated transcription) that are reported to play a pivotal role in the function of HSCs, therapies for bone marrow transplantation, and the relationship between HSCs and autoimmune diseases. It also demonstrates the current studies on the effects of high-fat diets and nutrients (i.e., vitamins, amino acids, probiotics and prebiotics) on regulating HSCs, providing a deep insight into the future HSC research. |
format | Online Article Text |
id | pubmed-10255666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102556662023-06-10 Hematopoietic Stem Cell: Regulation and Nutritional Intervention Sun, Siyuan Han, Yingxue Lei, Yumei Yu, Yifei Dong, Yanbin Chen, Juan Nutrients Review Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarizes the intrinsic factors (i.e., RNA-binding protein, modulators in epigenetics and enhancer–promotor-mediated transcription) that are reported to play a pivotal role in the function of HSCs, therapies for bone marrow transplantation, and the relationship between HSCs and autoimmune diseases. It also demonstrates the current studies on the effects of high-fat diets and nutrients (i.e., vitamins, amino acids, probiotics and prebiotics) on regulating HSCs, providing a deep insight into the future HSC research. MDPI 2023-06-01 /pmc/articles/PMC10255666/ /pubmed/37299568 http://dx.doi.org/10.3390/nu15112605 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sun, Siyuan Han, Yingxue Lei, Yumei Yu, Yifei Dong, Yanbin Chen, Juan Hematopoietic Stem Cell: Regulation and Nutritional Intervention |
title | Hematopoietic Stem Cell: Regulation and Nutritional Intervention |
title_full | Hematopoietic Stem Cell: Regulation and Nutritional Intervention |
title_fullStr | Hematopoietic Stem Cell: Regulation and Nutritional Intervention |
title_full_unstemmed | Hematopoietic Stem Cell: Regulation and Nutritional Intervention |
title_short | Hematopoietic Stem Cell: Regulation and Nutritional Intervention |
title_sort | hematopoietic stem cell: regulation and nutritional intervention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255666/ https://www.ncbi.nlm.nih.gov/pubmed/37299568 http://dx.doi.org/10.3390/nu15112605 |
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