Cargando…
The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis
Vitamin D can modulate immune responses, and its deficiency is linked to increased autoimmunity and susceptibility to infection. In the general population, it has been observed that serum vitamin D levels are connected with the risk of COVID-19 and its severity. Our study aims to examine reported fi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255765/ https://www.ncbi.nlm.nih.gov/pubmed/37299555 http://dx.doi.org/10.3390/nu15112588 |
_version_ | 1785056951186489344 |
---|---|
author | Szarpak, Luiza Feduniw, Stepan Pruc, Michal Ciebiera, Michal Cander, Basar Rahnama-Hezavah, Mansur Szarpak, Łukasz |
author_facet | Szarpak, Luiza Feduniw, Stepan Pruc, Michal Ciebiera, Michal Cander, Basar Rahnama-Hezavah, Mansur Szarpak, Łukasz |
author_sort | Szarpak, Luiza |
collection | PubMed |
description | Vitamin D can modulate immune responses, and its deficiency is linked to increased autoimmunity and susceptibility to infection. In the general population, it has been observed that serum vitamin D levels are connected with the risk of COVID-19 and its severity. Our study aims to examine reported findings on the effect of vitamin D serum levels on infection of COVID-19 during pregnancy. PubMed, Web of Science, Embase, and Cochrane Library were searched for relevant studies. Serum vitamin D serum levels in COVID-19-positive and COVID-19-negative pregnant women were 24.61 ± 20.86 ng/mL and 24.12 ± 17.33 ng/mL, respectively. In mild vs. moderate to critical COVID-19 pregnant women, vitamin D serum levels were 16.71 ± 9.04 ng/mL vs. 10.7 ± 9.37 ng/mL and severe vs. non-severe were 13.21 ± 11.47 ng/mL vs. 15.76 ± 10.0 ng/mL. Only one study reported vitamin D serum levels in the placenta of COVID-19-positive pregnant women compared with the control and results varied and amounted to 14.06 ± 0.51 ng/mL vs. 12.45 ± 0.58 ng/mL, respectively. Vitamin D deficiency tends to be common in pregnant women who have COVID-19, and the level of this vitamin has been demonstrated to have a strong correlation with the severity of the illness. As vitamin D serum levels correlate with COVID-19 symptoms and even with its occurrence, appropriate vitamin D supplementation in the prenatal period is suggested. |
format | Online Article Text |
id | pubmed-10255765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102557652023-06-10 The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis Szarpak, Luiza Feduniw, Stepan Pruc, Michal Ciebiera, Michal Cander, Basar Rahnama-Hezavah, Mansur Szarpak, Łukasz Nutrients Review Vitamin D can modulate immune responses, and its deficiency is linked to increased autoimmunity and susceptibility to infection. In the general population, it has been observed that serum vitamin D levels are connected with the risk of COVID-19 and its severity. Our study aims to examine reported findings on the effect of vitamin D serum levels on infection of COVID-19 during pregnancy. PubMed, Web of Science, Embase, and Cochrane Library were searched for relevant studies. Serum vitamin D serum levels in COVID-19-positive and COVID-19-negative pregnant women were 24.61 ± 20.86 ng/mL and 24.12 ± 17.33 ng/mL, respectively. In mild vs. moderate to critical COVID-19 pregnant women, vitamin D serum levels were 16.71 ± 9.04 ng/mL vs. 10.7 ± 9.37 ng/mL and severe vs. non-severe were 13.21 ± 11.47 ng/mL vs. 15.76 ± 10.0 ng/mL. Only one study reported vitamin D serum levels in the placenta of COVID-19-positive pregnant women compared with the control and results varied and amounted to 14.06 ± 0.51 ng/mL vs. 12.45 ± 0.58 ng/mL, respectively. Vitamin D deficiency tends to be common in pregnant women who have COVID-19, and the level of this vitamin has been demonstrated to have a strong correlation with the severity of the illness. As vitamin D serum levels correlate with COVID-19 symptoms and even with its occurrence, appropriate vitamin D supplementation in the prenatal period is suggested. MDPI 2023-05-31 /pmc/articles/PMC10255765/ /pubmed/37299555 http://dx.doi.org/10.3390/nu15112588 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szarpak, Luiza Feduniw, Stepan Pruc, Michal Ciebiera, Michal Cander, Basar Rahnama-Hezavah, Mansur Szarpak, Łukasz The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis |
title | The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis |
title_full | The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis |
title_fullStr | The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis |
title_full_unstemmed | The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis |
title_short | The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis |
title_sort | vitamin d serum levels in pregnant women affected by covid-19: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255765/ https://www.ncbi.nlm.nih.gov/pubmed/37299555 http://dx.doi.org/10.3390/nu15112588 |
work_keys_str_mv | AT szarpakluiza thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT feduniwstepan thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT prucmichal thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT ciebieramichal thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT canderbasar thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT rahnamahezavahmansur thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT szarpakłukasz thevitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT szarpakluiza vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT feduniwstepan vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT prucmichal vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT ciebieramichal vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT canderbasar vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT rahnamahezavahmansur vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis AT szarpakłukasz vitamindserumlevelsinpregnantwomenaffectedbycovid19asystematicreviewandmetaanalysis |