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Novel Rhinological Application of Polylactic Acid—An In Vitro Study

A novel approach to the treatment of sinusitis is the use of nasal stents. The stent is loaded with a corticosteroid, which prevents complications in the wound-healing process. The design is such that it will prevent the sinus from closing again. The stent is 3D printed using a fused deposition mode...

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Detalles Bibliográficos
Autores principales: Gowrav, M. P., Siree, K. G., Amulya, T. M., Bharathi, M. B., Ghazwani, Mohammed, Alamri, Ali, Alalkami, Abdulatef Y., Kumar, T. M. Pramod, Ahmed, Mohammed Muqtader, Rahamathulla, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255904/
https://www.ncbi.nlm.nih.gov/pubmed/37299320
http://dx.doi.org/10.3390/polym15112521
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author Gowrav, M. P.
Siree, K. G.
Amulya, T. M.
Bharathi, M. B.
Ghazwani, Mohammed
Alamri, Ali
Alalkami, Abdulatef Y.
Kumar, T. M. Pramod
Ahmed, Mohammed Muqtader
Rahamathulla, Mohamed
author_facet Gowrav, M. P.
Siree, K. G.
Amulya, T. M.
Bharathi, M. B.
Ghazwani, Mohammed
Alamri, Ali
Alalkami, Abdulatef Y.
Kumar, T. M. Pramod
Ahmed, Mohammed Muqtader
Rahamathulla, Mohamed
author_sort Gowrav, M. P.
collection PubMed
description A novel approach to the treatment of sinusitis is the use of nasal stents. The stent is loaded with a corticosteroid, which prevents complications in the wound-healing process. The design is such that it will prevent the sinus from closing again. The stent is 3D printed using a fused deposition modeling printer, which enhances the customization. The polymer utilized for the purpose of 3D printing is polylactic acid (PLA). The compatibility between the drugs and polymers is confirmed by FT-IR and DSC. The drug is loaded onto the polymer by soaking the stent in the drug’s solvent, known as the solvent casting method. Using this method, approximately 68% of drug loading is found to be achieved onto the PLA filaments, and a total of 72.8% of drug loading is obtained in terms of the 3D-printed stent. Drug loading is confirmed by the morphological characteristics of the stent by SEM, where the loaded drug is clearly visible as white specks on the surface of the stent. Drug release characterization is conducted by dissolution studies, which also confirm drug loading. The dissolution studies show that the release of drugs from the stent is constant and not erratic. Biodegradation studies were conducted after increasing the rate of degradation of PLA by soaking it in PBS for a predetermined duration of time. The mechanical properties of the stent, such as stress factor and maximum displacement, are discussed. The stent has a hairpin-like mechanism for opening inside the nasal cavity.
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spelling pubmed-102559042023-06-10 Novel Rhinological Application of Polylactic Acid—An In Vitro Study Gowrav, M. P. Siree, K. G. Amulya, T. M. Bharathi, M. B. Ghazwani, Mohammed Alamri, Ali Alalkami, Abdulatef Y. Kumar, T. M. Pramod Ahmed, Mohammed Muqtader Rahamathulla, Mohamed Polymers (Basel) Article A novel approach to the treatment of sinusitis is the use of nasal stents. The stent is loaded with a corticosteroid, which prevents complications in the wound-healing process. The design is such that it will prevent the sinus from closing again. The stent is 3D printed using a fused deposition modeling printer, which enhances the customization. The polymer utilized for the purpose of 3D printing is polylactic acid (PLA). The compatibility between the drugs and polymers is confirmed by FT-IR and DSC. The drug is loaded onto the polymer by soaking the stent in the drug’s solvent, known as the solvent casting method. Using this method, approximately 68% of drug loading is found to be achieved onto the PLA filaments, and a total of 72.8% of drug loading is obtained in terms of the 3D-printed stent. Drug loading is confirmed by the morphological characteristics of the stent by SEM, where the loaded drug is clearly visible as white specks on the surface of the stent. Drug release characterization is conducted by dissolution studies, which also confirm drug loading. The dissolution studies show that the release of drugs from the stent is constant and not erratic. Biodegradation studies were conducted after increasing the rate of degradation of PLA by soaking it in PBS for a predetermined duration of time. The mechanical properties of the stent, such as stress factor and maximum displacement, are discussed. The stent has a hairpin-like mechanism for opening inside the nasal cavity. MDPI 2023-05-30 /pmc/articles/PMC10255904/ /pubmed/37299320 http://dx.doi.org/10.3390/polym15112521 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gowrav, M. P.
Siree, K. G.
Amulya, T. M.
Bharathi, M. B.
Ghazwani, Mohammed
Alamri, Ali
Alalkami, Abdulatef Y.
Kumar, T. M. Pramod
Ahmed, Mohammed Muqtader
Rahamathulla, Mohamed
Novel Rhinological Application of Polylactic Acid—An In Vitro Study
title Novel Rhinological Application of Polylactic Acid—An In Vitro Study
title_full Novel Rhinological Application of Polylactic Acid—An In Vitro Study
title_fullStr Novel Rhinological Application of Polylactic Acid—An In Vitro Study
title_full_unstemmed Novel Rhinological Application of Polylactic Acid—An In Vitro Study
title_short Novel Rhinological Application of Polylactic Acid—An In Vitro Study
title_sort novel rhinological application of polylactic acid—an in vitro study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255904/
https://www.ncbi.nlm.nih.gov/pubmed/37299320
http://dx.doi.org/10.3390/polym15112521
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