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Development and Evaluation of a Simulation-Based Algorithm to Optimize the Planning of Interim Analyses for Clinical Trials in ALS

BACKGROUND AND OBJECTIVES: Late-phase clinical trials for neurodegenerative diseases have a low probability of success. In this study, we introduce an algorithm that optimizes the planning of interim analyses for clinical trials in amyotrophic lateral sclerosis (ALS) to better use the time and resou...

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Detalles Bibliográficos
Autores principales:	van Unnik, Jordi W.J., Nikolakopoulos, Stavros, Eijkemans, Marinus J.C., Gonzalez-Bermejo, Jésus, Bruneteau, Gaelle, Morelot-Panzini, Capucine, van den Berg, Leonard H., Cudkowicz, Merit E., McDermott, Christopher J., Similowski, Thomas, van Eijk, Ruben P.A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256133/ https://www.ncbi.nlm.nih.gov/pubmed/37085329 http://dx.doi.org/10.1212/WNL.0000000000207306

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