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author Gisladottir, Rosa S.
Helgason, Agnar
Halldorsson, Bjarni V.
Helgason, Hannes
Borsky, Michal
Chien, Yu-Ren
Gudnason, Jon
Gudjonsson, Sigurjon A.
Moisik, Scott
Dediu, Dan
Thorleifsson, Gudmar
Tragante, Vinicius
Bustamante, Mariana
Jonsdottir, Gudrun A.
Stefansdottir, Lilja
Rutsdottir, Gudrun
Magnusson, Sigurdur H.
Hardarson, Marteinn
Ferkingstad, Egil
Halldorsson, Gisli H.
Rognvaldsson, Solvi
Skuladottir, Astros
Ivarsdottir, Erna V.
Norddahl, Gudmundur
Thorgeirsson, Gudmundur
Jonsdottir, Ingileif
Ulfarsson, Magnus O.
Holm, Hilma
Stefansson, Hreinn
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
author_facet Gisladottir, Rosa S.
Helgason, Agnar
Halldorsson, Bjarni V.
Helgason, Hannes
Borsky, Michal
Chien, Yu-Ren
Gudnason, Jon
Gudjonsson, Sigurjon A.
Moisik, Scott
Dediu, Dan
Thorleifsson, Gudmar
Tragante, Vinicius
Bustamante, Mariana
Jonsdottir, Gudrun A.
Stefansdottir, Lilja
Rutsdottir, Gudrun
Magnusson, Sigurdur H.
Hardarson, Marteinn
Ferkingstad, Egil
Halldorsson, Gisli H.
Rognvaldsson, Solvi
Skuladottir, Astros
Ivarsdottir, Erna V.
Norddahl, Gudmundur
Thorgeirsson, Gudmundur
Jonsdottir, Ingileif
Ulfarsson, Magnus O.
Holm, Hilma
Stefansson, Hreinn
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
author_sort Gisladottir, Rosa S.
collection PubMed
description The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system.
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spelling pubmed-102561712023-06-10 Sequence variants affecting voice pitch in humans Gisladottir, Rosa S. Helgason, Agnar Halldorsson, Bjarni V. Helgason, Hannes Borsky, Michal Chien, Yu-Ren Gudnason, Jon Gudjonsson, Sigurjon A. Moisik, Scott Dediu, Dan Thorleifsson, Gudmar Tragante, Vinicius Bustamante, Mariana Jonsdottir, Gudrun A. Stefansdottir, Lilja Rutsdottir, Gudrun Magnusson, Sigurdur H. Hardarson, Marteinn Ferkingstad, Egil Halldorsson, Gisli H. Rognvaldsson, Solvi Skuladottir, Astros Ivarsdottir, Erna V. Norddahl, Gudmundur Thorgeirsson, Gudmundur Jonsdottir, Ingileif Ulfarsson, Magnus O. Holm, Hilma Stefansson, Hreinn Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Sulem, Patrick Stefansson, Kari Sci Adv Biomedicine and Life Sciences The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system. American Association for the Advancement of Science 2023-06-09 /pmc/articles/PMC10256171/ /pubmed/37294764 http://dx.doi.org/10.1126/sciadv.abq2969 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Gisladottir, Rosa S.
Helgason, Agnar
Halldorsson, Bjarni V.
Helgason, Hannes
Borsky, Michal
Chien, Yu-Ren
Gudnason, Jon
Gudjonsson, Sigurjon A.
Moisik, Scott
Dediu, Dan
Thorleifsson, Gudmar
Tragante, Vinicius
Bustamante, Mariana
Jonsdottir, Gudrun A.
Stefansdottir, Lilja
Rutsdottir, Gudrun
Magnusson, Sigurdur H.
Hardarson, Marteinn
Ferkingstad, Egil
Halldorsson, Gisli H.
Rognvaldsson, Solvi
Skuladottir, Astros
Ivarsdottir, Erna V.
Norddahl, Gudmundur
Thorgeirsson, Gudmundur
Jonsdottir, Ingileif
Ulfarsson, Magnus O.
Holm, Hilma
Stefansson, Hreinn
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
Sequence variants affecting voice pitch in humans
title Sequence variants affecting voice pitch in humans
title_full Sequence variants affecting voice pitch in humans
title_fullStr Sequence variants affecting voice pitch in humans
title_full_unstemmed Sequence variants affecting voice pitch in humans
title_short Sequence variants affecting voice pitch in humans
title_sort sequence variants affecting voice pitch in humans
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256171/
https://www.ncbi.nlm.nih.gov/pubmed/37294764
http://dx.doi.org/10.1126/sciadv.abq2969
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