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Sequence variants affecting voice pitch in humans
The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We sh...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256171/ https://www.ncbi.nlm.nih.gov/pubmed/37294764 http://dx.doi.org/10.1126/sciadv.abq2969 |
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author | Gisladottir, Rosa S. Helgason, Agnar Halldorsson, Bjarni V. Helgason, Hannes Borsky, Michal Chien, Yu-Ren Gudnason, Jon Gudjonsson, Sigurjon A. Moisik, Scott Dediu, Dan Thorleifsson, Gudmar Tragante, Vinicius Bustamante, Mariana Jonsdottir, Gudrun A. Stefansdottir, Lilja Rutsdottir, Gudrun Magnusson, Sigurdur H. Hardarson, Marteinn Ferkingstad, Egil Halldorsson, Gisli H. Rognvaldsson, Solvi Skuladottir, Astros Ivarsdottir, Erna V. Norddahl, Gudmundur Thorgeirsson, Gudmundur Jonsdottir, Ingileif Ulfarsson, Magnus O. Holm, Hilma Stefansson, Hreinn Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Sulem, Patrick Stefansson, Kari |
author_facet | Gisladottir, Rosa S. Helgason, Agnar Halldorsson, Bjarni V. Helgason, Hannes Borsky, Michal Chien, Yu-Ren Gudnason, Jon Gudjonsson, Sigurjon A. Moisik, Scott Dediu, Dan Thorleifsson, Gudmar Tragante, Vinicius Bustamante, Mariana Jonsdottir, Gudrun A. Stefansdottir, Lilja Rutsdottir, Gudrun Magnusson, Sigurdur H. Hardarson, Marteinn Ferkingstad, Egil Halldorsson, Gisli H. Rognvaldsson, Solvi Skuladottir, Astros Ivarsdottir, Erna V. Norddahl, Gudmundur Thorgeirsson, Gudmundur Jonsdottir, Ingileif Ulfarsson, Magnus O. Holm, Hilma Stefansson, Hreinn Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Sulem, Patrick Stefansson, Kari |
author_sort | Gisladottir, Rosa S. |
collection | PubMed |
description | The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system. |
format | Online Article Text |
id | pubmed-10256171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-102561712023-06-10 Sequence variants affecting voice pitch in humans Gisladottir, Rosa S. Helgason, Agnar Halldorsson, Bjarni V. Helgason, Hannes Borsky, Michal Chien, Yu-Ren Gudnason, Jon Gudjonsson, Sigurjon A. Moisik, Scott Dediu, Dan Thorleifsson, Gudmar Tragante, Vinicius Bustamante, Mariana Jonsdottir, Gudrun A. Stefansdottir, Lilja Rutsdottir, Gudrun Magnusson, Sigurdur H. Hardarson, Marteinn Ferkingstad, Egil Halldorsson, Gisli H. Rognvaldsson, Solvi Skuladottir, Astros Ivarsdottir, Erna V. Norddahl, Gudmundur Thorgeirsson, Gudmundur Jonsdottir, Ingileif Ulfarsson, Magnus O. Holm, Hilma Stefansson, Hreinn Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Sulem, Patrick Stefansson, Kari Sci Adv Biomedicine and Life Sciences The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system. American Association for the Advancement of Science 2023-06-09 /pmc/articles/PMC10256171/ /pubmed/37294764 http://dx.doi.org/10.1126/sciadv.abq2969 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Gisladottir, Rosa S. Helgason, Agnar Halldorsson, Bjarni V. Helgason, Hannes Borsky, Michal Chien, Yu-Ren Gudnason, Jon Gudjonsson, Sigurjon A. Moisik, Scott Dediu, Dan Thorleifsson, Gudmar Tragante, Vinicius Bustamante, Mariana Jonsdottir, Gudrun A. Stefansdottir, Lilja Rutsdottir, Gudrun Magnusson, Sigurdur H. Hardarson, Marteinn Ferkingstad, Egil Halldorsson, Gisli H. Rognvaldsson, Solvi Skuladottir, Astros Ivarsdottir, Erna V. Norddahl, Gudmundur Thorgeirsson, Gudmundur Jonsdottir, Ingileif Ulfarsson, Magnus O. Holm, Hilma Stefansson, Hreinn Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Sulem, Patrick Stefansson, Kari Sequence variants affecting voice pitch in humans |
title | Sequence variants affecting voice pitch in humans |
title_full | Sequence variants affecting voice pitch in humans |
title_fullStr | Sequence variants affecting voice pitch in humans |
title_full_unstemmed | Sequence variants affecting voice pitch in humans |
title_short | Sequence variants affecting voice pitch in humans |
title_sort | sequence variants affecting voice pitch in humans |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256171/ https://www.ncbi.nlm.nih.gov/pubmed/37294764 http://dx.doi.org/10.1126/sciadv.abq2969 |
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