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Impact of vitamin D receptor polymorphisms in selected metabolic disorders
Vitamin D (vitD) can regulate metabolic pathways in adipose tissue and pancreatic β cells by interacting with its vitamin D receptor (VDR). The aim of this study was to review original publications published in the last months and verify the relationship between genetic variants in the VDR gene and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256311/ https://www.ncbi.nlm.nih.gov/pubmed/37144463 http://dx.doi.org/10.1097/MCO.0000000000000945 |
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author | Fronczek, Martyna Osadnik, Tadeusz Banach, Maciej |
author_facet | Fronczek, Martyna Osadnik, Tadeusz Banach, Maciej |
author_sort | Fronczek, Martyna |
collection | PubMed |
description | Vitamin D (vitD) can regulate metabolic pathways in adipose tissue and pancreatic β cells by interacting with its vitamin D receptor (VDR). The aim of this study was to review original publications published in the last months and verify the relationship between genetic variants in the VDR gene and type 2 diabetes (T2D), metabolic syndrome (MetS), overweight, and obesity. RECENT FINDINGS: The recent studies concern genetic variants located in the coding and noncoding regions of the VDR gene. Some of the described genetic variants may affect VDR expression or posttranslational processing altered functionality or vitD binding capacity of VDR. Nevertheless, the data collected in recent months on the assessment of the relationship between VDR genetic variants and the risk of T2D, MetS, overweight, and obesity still do not give a clear answer to whether they have a direct impact on these metabolic disorders. SUMMARY: Analysis of the potential association between VDR genetic variants and parameters such as glycemia, body mass index, body fat, and lipid levels improves the current understanding of the pathogenesis of T2D, MetS, overweight, and obesity. A thorough understanding of this relationship may provide important information for individuals with pathogenic variants and enable the implementation of appropriate prevention against the development of these disorders. |
format | Online Article Text |
id | pubmed-10256311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-102563112023-06-10 Impact of vitamin D receptor polymorphisms in selected metabolic disorders Fronczek, Martyna Osadnik, Tadeusz Banach, Maciej Curr Opin Clin Nutr Metab Care GENES AND CELL METABOLISM: Edited by Anastasia Z. Kalea and Dorothy Klimis Vitamin D (vitD) can regulate metabolic pathways in adipose tissue and pancreatic β cells by interacting with its vitamin D receptor (VDR). The aim of this study was to review original publications published in the last months and verify the relationship between genetic variants in the VDR gene and type 2 diabetes (T2D), metabolic syndrome (MetS), overweight, and obesity. RECENT FINDINGS: The recent studies concern genetic variants located in the coding and noncoding regions of the VDR gene. Some of the described genetic variants may affect VDR expression or posttranslational processing altered functionality or vitD binding capacity of VDR. Nevertheless, the data collected in recent months on the assessment of the relationship between VDR genetic variants and the risk of T2D, MetS, overweight, and obesity still do not give a clear answer to whether they have a direct impact on these metabolic disorders. SUMMARY: Analysis of the potential association between VDR genetic variants and parameters such as glycemia, body mass index, body fat, and lipid levels improves the current understanding of the pathogenesis of T2D, MetS, overweight, and obesity. A thorough understanding of this relationship may provide important information for individuals with pathogenic variants and enable the implementation of appropriate prevention against the development of these disorders. Lippincott Williams & Wilkins 2023-07 2023-05-19 /pmc/articles/PMC10256311/ /pubmed/37144463 http://dx.doi.org/10.1097/MCO.0000000000000945 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | GENES AND CELL METABOLISM: Edited by Anastasia Z. Kalea and Dorothy Klimis Fronczek, Martyna Osadnik, Tadeusz Banach, Maciej Impact of vitamin D receptor polymorphisms in selected metabolic disorders |
title | Impact of vitamin D receptor polymorphisms in selected metabolic disorders |
title_full | Impact of vitamin D receptor polymorphisms in selected metabolic disorders |
title_fullStr | Impact of vitamin D receptor polymorphisms in selected metabolic disorders |
title_full_unstemmed | Impact of vitamin D receptor polymorphisms in selected metabolic disorders |
title_short | Impact of vitamin D receptor polymorphisms in selected metabolic disorders |
title_sort | impact of vitamin d receptor polymorphisms in selected metabolic disorders |
topic | GENES AND CELL METABOLISM: Edited by Anastasia Z. Kalea and Dorothy Klimis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256311/ https://www.ncbi.nlm.nih.gov/pubmed/37144463 http://dx.doi.org/10.1097/MCO.0000000000000945 |
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